#9
#10

Intestinal alkaline Phosphatase is increased by butyrate or vitamin K1 (~1500mcg/day). Butyrate comes from great prebiotics like inulin or dandilion or chikory root. Also acarbose and alpha cyclodextrin. Thats Intestinal AP, in the blood stream AP follows the level of LPS and more is not better. You want low numbers here.

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#11

Wow the timing of this thread couldn’t have come at a better time.

I’ve been struggling with low Alkaline Phosphatase for years. Blood tests show a level between 40-50 depending on the day I get it checked. Technically, 40 is the bottom of the range but clearly I want it higher.

Is this a supplement or drug I can access online or is it some new thing that will be impossible for me to get?

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#12

Ingested ALPI won’t cross the into the blood in significant quantities – it’s also a slightly different protein than you’re talking about. Injecting human proteins is a whole different – and expensive – ball game.

#13

You want low ALP. 50 is perfect, it’s what mine was when I was 50. Now mine is more like 85. The older you get the higher it goes. Low ALP indicates low LPS, or a low microbial burden. You’re doing great.

I should be looking for supplemental IAP, not you.

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#14

If you’d like more information you could have a fractionated test done through Labcorp or Quest Diagnostics.

This test shows “relative percentages of liver, bone, and intestinal alkaline phosphatase isoenzymes and total alkaline phosphatase.”

Marek Diagnostics offers the test for $25:

#15

Your ALP is in the lower normal range. Can you cite any RCT study that indicates that you should worry if your ALP is in the normal range?

“Even though researchers know the function of several other types of enzymes and have studied alkaline phosphatase for decades, they don’t yet know the exact function of ALP.”

“High levels of ALP may indicate liver disease or certain bone disorders, but an ALP test alone cannot diagnose a condition.”

#16

I’m going by Michael Lustgarten’s book on the microbial burden. Also the biomarker optimizer graphs:

https://biomarkeroptimizers.com/tools/test-results-analyzer/

Lustgarten says when serum ALP is more than 48 it increases your all cause mortality. He shows a graph that looks a lot like the one in biomarker optimizer. The higher the worse.

Intestinal ALP decreases with age, letting more LPS through the gut into the serum. As serum LPS increases, the body increases serum ALP to take care of it. ALP gets rid of LPS.

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#17

I don’t think Michael Lustgarten puts too much weight on any particular test, and the majority of the information is about observational studies, not RCTs. BTW can you point to his video about ALT?
The graph you point to is based on an observational study only.
“Age and sex variation in serum albumin concentration: an observational study”

#18

Sorry, I think I saw that here too not that long ago but can’t find it now.

I don’t know for sure but I like that he sticks his neck out a bit and tells the reader what he thinks based on observational studies. I learned a great deal from his book and even if it’s wrong at least I know the characters a little better. LPS, ALP, CD38,NAD, LL-37. That article you pointed to said they don’t know what it does. He says if you work on barrier function and reduce microbial burden it will go down. Anything over 48 is bad. So at least I have an idea what to do.

#19

It’s fine to want to adjust all of our health parameters to the best possible levels, but ALT is not high on my list.

As you can see ALT isn’t even on the Levine-based age spreadsheet calculator.

Also, ALT is not found as one of the parameters on the Aging.Ai, 19 parameter input calculator.

(As, a side note: Why I am not big on CRP measurements unless you are sick and it is being used to help with a diagnosis) “C-reactive protein value can change by orders of magnitude in the presence of a wound or infection.”

FWIW, (Maybe, posted before?):

Ranking the influences in order as calculated by @JGC Retired Professor of Physics 4 yrs ago.

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#20

ALT is alanine transaminase, not to be confused with ALP alkyline phosphatase. Alkyline Phosphatase is in the levine calculator. And I don’t really understand the list you put out but it looks like it’s worth more than CRP.

I’ve been talking about ALP.

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#21

Don’t know enough but your blood test might be different from what you want in your micro biome

See et this

#22

Anyone have any experience on whether the peptide BPC157 might help ALP with fighting leaky gut?

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#23

You’re sure about this? My recent result was 40 and flagged as LOW. I read deficiencies in magnesium and/or zinc could cause that, even though I consume plenty of both.

#24

I’m not a doctor. I read about this in Michael Lustgarten’s excellent book “Microbial Burden and what you can do about it”. I’m sure the microbial burden is not the only thing that affects AP. Google lists protein deficiency and a couple diseases as well. If these things are ruled out then that leaves really good news about your microbial burden.

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#26

Update, I asked him and this was his response

“< 48 for ALP is associated with lowest all-cause mortality risk, so you’re likely good there

Liver enzymes and risk of all-cause mortality in general populations: a systematic review and meta-analysis - PubMed “

So thank you for bringing it to my attention @Bicep . I’m not so worried anymore

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#27

Have you tried supplementing with these? It looks like one of the safest approaches right now in terms of longevity.

I was hoping someone had tried with available current IALP:

#28

Unfortunately, it appears that Synthetic Biologics (now Theriva Biologics) has abandoned further work on this asse. It’s not currently listed in their pipeline, and a press release from November mentions " lower expenses related to our Phase 1a clinical trial of SYN-020 which has completed".

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#29

An update to this thread. This article from 2024 brings forward the theoretical framework that challenges the mainstream theory of ageing. For those not familiar with the term “smurf” in ageing - they have found that when flies are fed with food that contains a blue dye, then 2–3 days before the death, the fly turns blue. Therefore, the name smurf. This smurf phenotype is due to the breakdown of the intestinal barrier, a leaky gut. They don’t say that “leaky gut” is causative of an impeding death, but there is a very strong correlation between the smurf phenotype and an imminent death. Now they try to find signals that precede the smurf phenotype.

"It is demonstrated that the smurf phenotype is a harbinger of death across species, allowing for the identification of individuals about to die from natural conditions 2–3 days prior to death. As time passes for a non-Smurf, its gene expression becomes noisier until it reaches a point—an hypothetical “Smurf Transition Point” yet to be characterized—at which individuals undergo an abrupt modification of the transcriptome, reminiscent of the “transcription hallmarks of ageing” leading to a general stereotyped collapse "

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