#77

You raise a really interesting question. A synthesized protein food probably shouldn’t mimic existing meat/fish.
I wonder whether an ideal synthesized protein would additionally have different time release for different amino acids. Taking taurine and glycine together inhibits absorption, so I take them at different times of day. A time release component would be interesting and useful

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#78

I always felt that the secret code to a very long life is hidden in protein/amino acids, or at least related somehow to aminos. Clearly, I’m not qualified in the field to be able to back my theory up, but it’s just mind boggling (for me) how taking aminos (supplements not food) you can derive almost instantaneous results. Rarely do any other substances/supplements have such noticeable effect (i have previously mentioned that lysine in high doses gets rid of cold sores, carnosine fixes the muscle spasm, arginine big dilation and sexual effects etc.) As you rightly point out, perhaps which ones should be taken together or in which daily quantities and frequencies might have the answer. Perhaps, some may not even be beneficial to be taken every day, while others may need be supplied few times within the day. I really think this area (aminos and longevity) needs way more attention from people/scientist in this field.
I also believe that the answer (to longevity) is probably way simpler than the complex pathways and mechanisms and all other areas/things these scientists are chasing. I feel it could be something that when it will become obvious everyone will say, how the hell didn’t we see it. I’m fascinated by the field, and not necessarily just to live longer, but rather for us humans to be able to break the mold, and to somehow be able to be much more in control of our health and even our longevity. I am certain that it is a matter of time before people will casually live to 110 and up.

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#79

@SNK There are some threads on the forum about protein and protein restriction on longevity - might want to do a search and read those

There is also a large scientific literature beyond those threads

For instance a pubmed search for just “amino acid” and “longevity” shows more than two thousand different scientific papers:

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#81

Restricting dietary isoleucine increased the lifespan and healthspan of the mice

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#83

Unfortunately, I do not. Would be nice to have answers to all questions. I’m sure that the right lifestyle (diet, exercise, sleep) is the most important. I wish more young people understood that earlier in life.

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#84

Glutamine is the most abundant amino acid and I found that it helps with better mood, concentration, psyche and overall well-being!

I have used the powder form in the past mixed with different juices!

It could improve a person’s longevity as well!

#85

Based on my reading, Glutamine is supposed to be in abundance throughout your life unlike glycine and cysteine so I always thought there was no need to supplement it. It’s also a cancer food. So you may want to be careful.

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#86

Ouch to that, but thanks for reminding us.

#87

I take 7 grs. NAC and 6 glycine in two takes along the day.

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#88

https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/theanine

l-Theanine is a product that is naturally found in green tea, which is a structural analog of glutamate, an excitatory neurotransmitter. Thus, it may block the effects of glutamate and increase GABA, an inhibitory neurotransmitter.

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#89

The carbohydrate glucose and the amino acid glutamine are the two major fermentable fuels in the body that can drive the growth of glioblastoma, as well as most cancers, Seyfried said. Yet relatively few studies have simultaneously targeted these fuels as candidates for therapeutic management of glioblastoma.

In a report last December, Seyfried and colleagues identified glutamine fermentation as the “missing link” in the metabolic theory of cancer first posited by Nobel laureate Otto Warburg in 1931. Contrary to the theory that cancer is determined by genomic instability in the nucleus of a cell, the metabolic theory of cancer holds that cancer’s deadly path begins in the mitochondria, where cells generate energy.

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#90

Glucose and a lot of MTOR activators are “cancer food”. I would never throw away Glutamine because cancer likes it. In fact most studies showed it is one of the most important interventions for a healthy gut.

If you want to do an anti cancer intervention from time to time just do some kind of glucose, glutamine and aminoacids inhibition protocol. Fasting + some drugs +green tea (ECGC).

#91

Depend how many cancerous cells you have.

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#92

Do you have any reference regarding the absorption of Taurine, Glycine and BAlanine via Glycine receptor + caffeine interaction?

#93

When I finish walk, and sit in my chair … i get small twitches in my calf’s and feet, and I get cramps in my feet in the middle of my heavy workouts … could it be Carnosine? I am Plant based + fish … I have lots of electrolytes daily and I take magnesium pre workout …

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#94

Yes, I discuss the Glycine receptor here:

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#95

I don’t know what other supplements you take, but for me vitamin D seems to give me leg cramps. Haven’t been able to pinpoint it to anything else other than vitamin D. It is a petty since I think Vit D has great immune effects and also a calming effect (for me at least). Now I only take few times per month as opposed to daily, but it never fails the day that I start it I start getting cramps.

Of note there is no leg cramps when I stay at the beach though, even though I’ve heard that one day at the beach you could get you 20,000IU’S.

#96

I used to take 4k IJ of D3 per day.

For a few months I didnt take it since I was outside in the sun.

But still I have cramps in my feet … my fingers start to cramp ( workout ) and sometimes my calfs … pisses me off.

#97

do you have cramps out of the blue, or just when you do physical activity?? Because for me i only get them when I walk or run long distances over 4 miles. If you get them even without physical activity, then you could have an underlying issue and should check it with your doctor IMO.

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#98

I used to have twitches all over my body … freaked me out, but since starting Taurine that stopped … I guess osmolyte effect it has.

I hope I dont have calcification in my lower extremities … we will see.

1 Like