#218

And genetics. As Judith Campisi said, the most important factor is having the right parents . . .

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#219

Fluvastatin is 3 times more expensive in Canada. I convinced my dr to switch from crestor. Will know in 3-6 months of any comparisons.

3 Likes
#220

This is a great list of things. I use about 50% of the drugs here. Since upping my acarbose to 100mg/per carb meal, I find the gas to be particularly odious with strong hydrogen sulfide smells. I know taurine is responsible for that gas production.

Do you find the 4g taurine with 200mg acarbose to have such an issue?

2 Likes
#221

I did initially from the acarbose but I haven’t gotten much gas in a while. As for the taurine, I’ve been taking at least 2g of it for gosh, ten years already? So any effects I may have had at the beginning, I wouldn’t remember anymore.

1 Like
#222

Taurine will produce sulfide smelling gas if it reaches the colon. Taurine has high affinity to the taurine transporter, so it’s unlikely that other amino acids will cause taurine malabsorption such that it makes it to the colon. The only notable exception is Beta-Alanine, which has a higher affinity for the taurine transporter. Given taking it away from Beta-Alanine, that practically leaves two options for why it’s making it the colon a) the transporters are saturated → take less taurine at once b) it’s moving too quickly through the digestive track to be absorbed → probably also just take less at once.

1 Like
#223

Glycine also blocks Beta Alanine and Taurine because all 3 use the Glycine receptor. Best to take these three separately and on an empty stomach.

Interestingly caffeine also blocks taurine absorption but they also enhance each other.

The receptor can be activated by a range of simple amino acids including glycine, β-alanine and taurine, and can be selectively blocked by the high-affinity competitive antagonist strychnine.[2] Caffeine is a competitive antagonist of GlyR.[3] Cannabinoids enhance the function.[4]

Marijuana enhances the absorption of Taurine and Glycine.

But stay away from the strychnine. :wink:

9 Likes
Best Amino Acids for Longevity
Low Risk Drugs and Supplements for Longevity
#224

Would you like to be able to easily see what other people are doing and have this information aggregated? I saw that request on this forum before and just built a beta site to help do that. If you’d like to help influence design and get this off the ground, looking for a few people to do a short user testing session :slight_smile:

4 Likes
#225

I’d love to test it!

#226

Awesome! I’ve sent you a message.

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#227

It would need to be editable as stacks often change.

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#228

Yes, agree! Does allow for editing and creating multiple different stacks.

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#229

I’m still relatively new to this forum and the plethora of interventions in use. I like seeing what others are doing … yet at times it is like reading Klingon. One thought on the this database:

It would be very helpful to have a reference “library” for what each intervention is and what it is intended to accomplish, to help me determine if it fits with my own intentions and needs. If this already exists somewhere, I’d love to get a link to it. Frequently, a simple list without the intent for each item is simply confusing … mostly for those of us who are just joining this journey.

5 Likes
#230

Great suggestion. I can add that.

1 Like
#231

If you are serious about wanting a reference library for the supplements, its probably best to subscribe to a service like Examine.com

Unfortunately they don’t provide much of anything for free, its paid.

The alternative is, I suspect wikipedia, which is really not that helpful or takes much more time to understand: Spermidine - Wikipedia

There must be some open databases on this type of issue. I know that @Gokhan has a personal list on his blog that is quite good as a place to start:

4 Likes
#232

The list below was my personal compilation of what I deemed as “relevant ideas” mentioned above in this thread. My criteria was admittedly subjective and totally biased based on my years of personal research. My goal in the compiling this outline was to organize the inputs into a useful “shopping list” of credible ideas, including things I may have overlooked. I wanted to see what was mentioned that I may not have fully investigated yet, as well as what overlaps with my current practices. I share the outline below in case it’s helpful…

Life * Habits

  • Exercise
    • Cardio
    • Strength training
  • Healthy diet
    • Avoid sugars
    • Avoid processed foods
    • Adequate protein
    • Diverse fruits and vegetables of many colors (polyphenols)
  • Gut Health
    • Avoid antibiotics
    • Avoid processed food
    • Increase fiber
    • Increase polyphenols
    • Increase fermented foods
    • Akkermansia
  • Periodic energy shortages.
    • Fasting
    • Time restricted eating
  • Sleep
  • Sauna/Cold Plunge
  • Social Karma (friends, hobbies, passion for life, meaningful work)
  • Things To Avoid:
    • Sunburn
    • AGEs in diet (advanced glycation end products from food cooking)
    • Drugs to wake up and/or drugs to fall asleep
    • Alcohol
    • Mouth breathing
    • Smoking
    • Pollution
  • Tests/Screenings
    • Regular bloodwork
    • Cancer (generally, the Grail test)
    • Cardiovascular (CAC and MRI)
    • DEXA scan
      • Proper body mass index
      • Monitor and reduce visceral fat
    • Blood pressure
  • Supplements (both prescription and over-the-counter)
    • Rapamycin
    • Senolytics
      • Dasatnib+Quercetin
      • Fisetin alone
      • Quercetin alone
    • Lipid Lowering & Reduce APOb (controversy on this topic)
      • Rosuvastatin
      • Ezetimide
      • Atorvastatin
    • Glucose Management (reduce insulin/IGF signaling)
      • SGLT2i
      • Empagliflozin
      • Metformin
      • Acarbose
    • Curing Deficiencies
      • Vitamin D3
      • B 12
      • Omega 3 Fish Oil
      • Magnesium
      • Vitamin K2 (MK4 & MK7)
    • Amino Acids
      • Taurine
      • GlyNAC (some people choose Glycine only without NAC)
      • Creatine
      • Collagen
    • PDE5 Inhibitors
      • Low dose tadalafil
      • Sildenafil
    • DHEA
    • CoQ10 Ubiquinol
    • Hyaluronic Acid
    • Lithium
    • Astaxanthin
    • Sulforaphane
    • Photobiomodulation (Red Light Therapy)
    • Worth noting – nobody with knowledge is using Resveratrol or NAD precursors.
17 Likes
#233

True. Examine was an initial thought for me too, at least for supplements. Good suggestion from @Steelart99 to highlight the intention of each intervention and then maybe provide further links. In the end, there isn’t a bulletproof solution as too many things either lack RCT’s and/or have many conflicting opinions on effectiveness. Guess that’s why we’re all here trying to figure it out!

1 Like
#234

Both examine and consumerlab are worth every penny. Amazing resources.

7 Likes
#235

@blsm what is your current dosage of melatonin?

#236

How do you do cancer screening and how often?

3 Likes
#237

Colonoscopy every 5-10 years.
PSA yearly
Mammograms every 2 years
Dermatologist skin survey yearly
PAP smears every 1-2 years
HPV Vaccine

There are probably others

5 Likes