#1

Mitopure, aka Nestle, seems a bit pricey at $125 for 60 500mg soft gels (so $2 per soft gel)

Other sources, like this one are more like 40 cents per 500mg soft gel:

https://www.amazon.com/VIVALIFER-Naturals-Supplement-Antioxidants-Mitochondrial/dp/B0D2NS1JQZ/

Also, how are they not being squashed by Nestle?

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#2

I used Urolithin A from Do Not Age for several months. Didnā€™t notice any positive or negative effects. Didnā€™t notice anything from Mitopure either. Nestle is trying to stop anyone from selling Urolithin A.

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#3

Urolithin A sounds good on paper, but I havenā€™t seen anything that moves the needle for me to want to buy it. Too many other supplements trump it. And, itā€™s pretty expensive. Iā€™d rather place other cheaper bets, like ergothioneine and boron.

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#4

Started with UA and 4 other ā€œexoticsā€ 3 months ago.

Will be doing a 7 month eval and in Sept will do our 5th DNAm test to see if the needle(s) moved and in which direction.

Of course this is a severely compromised eval as adding 5 things at once is not terribly ā€œscientificā€ but at 68, time is of the essence :slight_smile:

I think one of the ways some companies are getting around the IP issue is to combine UA with other compounds. At least that is my theory for now :slight_smile: Most of the patents Iā€™ve looked at are production related but some are more convoluted.

Interestingly, the more complex a patent is, itā€™s often easier to go around it.

#5

If the needle moves, youā€™ll have work to do.

#6

Hi @WJ_PhD Iā€™ve tried Mitopure but agree its expensive.

A couple of months ago I bought 30g Urolithin A from Aeternum UA. This is an Australian (Queensland) company - I paid A$100 (US$66). Iā€™ve checked out the company and they seem legit and they have published a HPLC certificate of analysis (look at the last image).

The product arrived professionally packaged but its not unwrapped yet. I have no affiliation with this company and Iā€™m not endorsing Urolithin A, but the compound seems interesting. I wonā€™t get around to testing it myself until Iā€™ve cycled off, and cleared, other compounds. That is at least a coupe of months away. Iā€™m strict about not mixing too much together.

Update: I found this review of Urolithin A. Thereā€™s video of the potential benefits and effects.

I just noticed a sale code 56FZMXVQ for 10% off.

I hope this is helpful!

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Study: Most NMN and Urolithin-A Supplements are Crap
#7

I have tried the Aeternum one as well as Mitopure. I think I noticed sleep problems from Aeternum (which to me is a positive sign of mitophagy). My sleep has improved a lot in the round, but goes in a cyclic manner worse when I take Rapamycin.

#8

Agreed, just not sure how to proceed :slight_smile:

I would love to do testing every 2 months but that is not in my budget t the moment, every 9 months is the best I can do for now. So that time restriction affects my feedback loop :frowning:

#9

That is a good price.

I pay $2.00 US per gram when I buy 400gmā€™s in bulk. Iā€™d probably get a better price by the Kg.

#10

Thanks everyone, I appreciate the comments and will look into the alternate sources.
Iā€™m definitely keeping an eye on urolithin A.

#11

Do you combine Urolithin with Rapamtcin? I was taking it for a while but quit when I started Rapa. They seem to do the same thing, eg, eliminate old cells and stimulate mitochondria. I was also taking Long Pepper, another senolytic, which I also stopped. Should I wait to see my results with the Rapa before adding them back?

#12

The recent systematic review, I actually consider Urolithin A is one of the most worthwhile supplements to take, ranking at least in the top two or three.

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#13

To each their own. If it works for you, go for it. I doubt it will be bad. I just feel there are better choices.