I tried NMN from several suppliers. As far I could tell it did zilch for me,
no increased energy no obvious change in my blood markers.
I will give it a second try, but using NMNH, which is relatively new in animal and in vitro studies, it appears to be better than NMN. It certainly is cheaper, but the same problems apply to getting a brand that contains the dose on the label.
“Even at concentrations significantly lower than NMN, NMNH demonstrated a nearly 10-fold increase in cellular NAD+ levels, showcasing its remarkable efficacy.”
"Based on the available research, NMNH appears to be a more potent and effective NAD+ enhancer compared to NMN.
"Key Findings
Cellular NAD+ Levels
In vitro studies have shown that NMNH treatment (100 μM) increased cellular NAD+ levels by 5-7 folds in HepG2 cells, while the same concentration of NMN only slightly increased NAD+ levels.
Even at concentrations significantly lower than NMN, NMNH demonstrated a nearly 10-fold increase in cellular NAD+ levels, showcasing its remarkable efficacy.
Enzymatic Pathways
NMNH is the reduced form of NMN, and it appears to be more efficiently converted to NAD+ by the enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT).
Stability
NMNH is more stable than NMN under alkaline pH and low-temperature conditions.
However, NMNH is less stable than NMN at neutral pH in solution, with a half-life of approximately 2.4 days at room temperature and pH 7.0.
“NMNH increased the reduced NAD (NADH) levels in cells and in mouse livers. Metabolomic analysis revealed that NMNH inhibited glycolysis and the TCA cycle. In vitro experiments demonstrated that NMNH induced cell cycle arrest and suppressed cell growth.”
“Together, our data highlight NMNH as a new NAD+ precursor with therapeutic potential for acute kidney injury, confirm the existence of a novel pathway for the recycling of reduced NAD+ precursors and establish NMNH as a member of the new family of reduced NAD+ precursors.”
