#1

There is limited anecdotal data available online about its use. It is available through a few different companies for “research purposes”. Based on comments I’ve found online, people are using anywhere between 2mg - 15mg daily. Has anyone tried this or have any thoughts about it?

4 Likes
268% Median Lifespan Increase with Indolepropionamide aka Indole-3-propionamide or IPAM – What this is, and why more studies NEED to be funded!
#2

Very very interesting. Do you have a link to one of these reputable “for research” vendors? Thank you :blush:

#3

It’s available in both a solution and powder: Indolepropionamide Solution (IPAM) – pglchem

I’ve ordered from this company before, and they’re reliable. Payment takes some knowledge of crypto or doing a bank transfer I believe. They are based in Ukraine.

#4

Thank you! Found this too , but unsure of quality https://everychem.com/product/indolepropionamide-solution-6mg-ml/

#5

Yes correct. I have not ordered from them before, but my understanding is they are also a reliable source.

1 Like
#6

Here is the link to “Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer’s disease”: https://www.sciencedirect.com/science/article/pii/S0969996121001522

#7

Nice, from what I’ve read it’s a very promising longevity molecule. I have no idea why it has not been discussed here before. I will be testing it soon.

#8

My only concern is negative impacts that research might uncover in a few years. But that’s always a risk…

#9

I’m also experimenting with IPAM sourced from pglchem, but I’m having contradictory effects.
Can we talk in private?

2 Likes
#10

The problem with that is the solution, tween-80, peg-400, propylene glycol are not good for longevity.

1 Like
#11

Woahhh. Gonna need to read up on this one a bit more! I’d love to see some data on C Elegans and other species.
https://genomics.senescence.info/drugs/drug_details.php?compound_name=Indolepropionamide

image
image2005×778 31.8 KB

1 Like
#12

Its actions on complex 1 are key in reducing the rate of mtDNA damage. I wonder if mk7 has similar effects. We don’t know, however, what side effects this has. It could be very significant.

#13

I just looked it up on Reddit and there are a bunch of people talking about taking it on a nootropics subreddit.

Strange that something so potent isn’t being studied more.

image
image1345×514 80.2 KB

#14

What was your experience?

1 Like
#15

All the info here seems to come from the same paper. Are there any other sources?

#16

I don’t think there is much research on this.

One paper referred to had it correcting the effect of toxins. It still needs a good look at because anything that is working around complex 1 is at the centre of the aging process.

#17

I’m talking to Ora Biomedical about getting Indolepropionamide to run a C Elegans lifespan study.

1 Like
#18

That would be interesting. The worm studies have lots of issues, but they are a relatively cheap data point. A mouse lifespan study would be really quite helpful.

#19

Worms are a good starting point, then move up to slightly larger species until we get to mice. Getting all of that data in between could get other researchers and groups eager to run the study. BTW I just made an in depth post on Indolepropionamide if you are interested.

#20

Where is the “in depth post”?

To me the question is whether Indolepropionamide has material effects in normal circumstances or only when complex 1 is compromised. It is also not clear how it compares to the longer chain menaquinones.

Obviously some people are taking it and it is endogenous to rats so probably more generally endogenous although it has a different pathway from tryptophan to that of melatonin.