I asked chatGPT to do a summary of the papers, it only looked at the first page which is only 10 papers, when it says there are 24 it is misleading people), however, and gave:
(I will try to get it to look at all of them).
Here’s an overview of the main findings reported in the 24 papers citing Poeggeler et al. (PMID 20421998). Broadly, these studies fall into several thematic areas:
- Gut microbiota–derived metabolites and the gut–brain axis
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Ahmed et al. (2022) review how microbial transformation of dietary and host molecules produces metabolites (e.g., short-chain fatty acids, 4-ethylphenylsulfate, trimethylamine-N-oxide) that cross the gut barrier, modulate blood–brain barrier integrity, and engage immunological, neuronal, and endocrine routes to influence brain function and behavior (考研).
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Edlund et al. (2017) used metabolomics to map peptidic small molecules secreted by the oral microbiome, revealing a vast “dark matter” of bioactive compounds whose physiological roles are largely unexplored (考研).
- Kynurenine pathway and indole derivatives in health and disease
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Wang et al. (2025) present an updated review of the kynurenine pathway’s metabolites—such as kynurenic acid and quinolinic acid—highlighting their diverse roles in immune modulation, neuroprotection, and redox homeostasis, and discussing therapeutic implications for neurodegenerative and psychiatric disorders (考研).
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Wei et al. (2019) demonstrate that an indole-derivative compound (NC001-8) activates the NRF2 antioxidant pathway in cellular Parkinson’s disease models, reducing oxidative damage and improving cell survival (考研).
- Antioxidant supplementation and lifespan extension
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Snell et al. (2012) tested combinations of antioxidants in the rotifer Brachionus manjavacas, finding that certain pairings extended lifespan significantly, whereas others had no effect or were detrimental—underscoring the importance of specific redox interactions (考研).
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Sadowska-Bartosz & Bartosz (2014) review human and animal trials of antioxidant supplements (e.g., vitamin E, coenzyme Q10), concluding that while biochemical markers of oxidative stress often improve, robust evidence for actual lifespan extension in humans remains lacking (考研).
- Comparative analyses of lifespan-extending compounds
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Berkel & Cacan (2021) perform a meta-analysis across yeast, worms, flies, and mice to rank compounds (e.g., rapamycin, metformin, resveratrol) by their efficacy in extending lifespan, identifying species-specific responsiveness and potential translational candidates (考研).
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Rukavina Mikusic et al. (2025) synthesize emerging data on how microbiota, mitochondrial function, and epigenetic modifications converge to regulate aging, proposing integrated therapeutic strategies targeting these interconnected pathways (考研).
- Metabolic and lipidomic profiling in disease contexts
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Weerd et al. (2024) compare the serum metabolome and plasma lipidome of early-treated phenylketonuria patients to healthy controls, uncovering persistent alterations in amino acid pathways and phospholipid classes despite dietary management (考研).
- Neuroprotection via mitochondrial support
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Collectively, these papers bolster the concept introduced by Poeggeler et al. that indole-based molecules can preserve mitochondrial integrity and promote organismal health and longevity—whether by modulating oxidative stress, engaging the NRF2 axis, or acting through the gut–brain axis to influence central nervous system resilience (考研).
Take-home message:
The citing literature expands on Poeggeler et al.’s finding that endogenous indoles protect mitochondria and extend lifespan by exploring:
- How microbiota-derived metabolites communicate with the brain (Ahmed et al.)
- The roles of kynurenine and other indole pathways in health and disease (Wang et al.; Wei et al.)
- The (often nuanced) effects of antioxidant supplements on aging (Snell et al.; Sadowska-Bartosz & Bartosz)
- Cross-species analyses of longevity compounds (Berkel & Cacan; Rukavina Mikusic et al.)
- Metabolic dysregulation in genetic metabolic disorders (Weerd et al.)
Together, these studies underscore the multifaceted interplay between metabolism, microbiota, redox biology, and epigenetics in shaping mitochondrial health and organismal lifespan.
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Good job.
The other ones might be referencing “Indole-3-Propionic Acid” which is a related compound, but not the same.
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I made it do more work:
What the 24 papers that cite Poeggeler et al., 2010 (“Indole-3-propionamide protects mitochondria…” PMID 20421998) actually add to the story
| Thematic thread (≈ number of papers) |
Consistent take-home message |
Representative examples |
| 1. Microbiota → mitochondria → brain & ageing (7 papers) |
Gut (and oral) microbes make small tryptophan/indole-derived or SCFA metabolites that fine-tune mitochondrial biogenesis, redox balance and epigenetics in host cells; dysbiosis therefore accelerates metabolic syndrome, neuroinflammation and cognitive decline, whereas pre-/post-biotics may slow it. |
Systematic review on the “microbiota-mitochondria-epigenome triad” (考研); “gut–brain axis & kynurenines” review (考研); microbiome & cognitive ageing (考研); prebiotics in Alzheimer’s (考研); gut microbial metabolism in AD 2024 (考研); oral-microbiome peptidomics gap (考研); carrageenan oligosaccharides extend Drosophila lifespan via gut flora (考研). |
| 2. Tryptophan–kynurenine/indole chemistry (6) |
Multiple groups zoom in on downstream metabolites of tryptophan (kynurenic acid, indole-3-propionic acid, novel ester/amide derivatives) as mitochondria-centric antioxidants, neuromodulators and even cholinesterase inhibitors, echoing Poeggeler’s concept that certain indoles are “endogenous melatonins”. |
2025 kynurenine-pathway mega-review (考研); esterified indole-3-propionic acid as dual AChE/BuChE blocker (考研); kynurenic acid & analogues improve stress resistance and survival in bdelloid rotifers (考研); Parkinson’s cell study with synthetic indole NC001-8 activating NRF2 (考研). |
| 3. Classic and “mito-targeted” antioxidants (7) |
Meta-analyses and rotifer screens confirm that only a subset or specific combinations of antioxidants (e.g., aspirin, minocycline, lipophilic algal lipids) extend lifespan—probably because they reach and protect mitochondria efficiently. |
DrugAge-wide comparison of lifespan-extending molecules (aspirin #1) (考研); antioxidants work in rotifers but only in a few cocktails (考研); red-algal extracts add 9–14 % to rotifer life span (考研); comprehensive antioxidant-supplementation review (考研). |
| 4. Melatonin & friends at mitochondria (4) |
Building on Poeggeler’s earlier melatonin work, authors show that melatonin (i) re-programs cancer-cell metabolism towards OXPHOS, (ii) shares a “common mitochondrial-respiratory target” with other bioactives, and (iii) speeds β-amyloid clearance via meningeal lymphatics. |
Melatonin-mitochondria-cancer review (考研); melatonin/respiration review (考研); melatonin promotes Aβ lymphatic drainage in APP mice (考研). |
| 5. Gas & hormone signalling to mitochondria (3) |
Endogenous gases/hormones match indoles in safeguarding mitochondrial fitness: (a) nitric-oxide tone predicts human longevity, (b) thyroid hormones trigger follicular mitochondrial biogenesis, (c) amino-acid supplementation rescues energy failure in α-synuclein-stressed neurons. |
NO–longevity review (考研); T3/T4 up-regulate mitochondrial mass in human hair follicles (考研); amino-acids drop ROS in PD cell model (考研). |
| 6. Methodology & model-organism papers (3) |
Rotifers are promoted as rapid, vertebrate-relevant ageing models; life-table and omics tools make them ideal for testing mitochondrial protectants such as indole derivatives, antioxidants and algal lipids. |
Rotifers as ageing models review (考研) plus lifespan/antioxidant screens above. |
Big picture synthesis
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Convergence on mitochondria — Whether the intervention is a microbial metabolite, melatonin analogue, hormone, gas transmitter or antioxidant mix, the beneficial phenotype almost always tracks back to improved mitochondrial redox coupling, biogenesis or signalling—precisely what Poeggeler et al. proposed for indole-3-propionamide.
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Microbiome moves centre-stage — Several post-2020 papers re-frame indole/kynurenine chemistry as host–microbe co-metabolism, suggesting that nurturing the right microbes (or delivering their metabolites) could be a practical route to the mitochondrial protection Poeggeler demonstrated in rodents and rotifers.
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Therapeutic scouting is widening — High-throughput drug-age mining, lipidomics, cholinesterase docking and rotifer combinatorial screens all extend Poeggeler’s single-compound insight toward pipelines for next-generation mito-protectants.
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Translational hints — Melatonin and NO reviews argue for repurposing cheap, well-tolerated agents, while cholinesterase-blocking indole-3-propionate esters and microbiota-targeted prebiotics point to disease-specific tailoring (Alzheimer’s, Parkinson’s, metabolic syndrome).
In short: The citing literature corroborates and broadens Poeggeler’s central thesis—small, naturally occurring molecules that reach and stabilise mitochondria can slow functional decline across taxa—and now links it to gut microbiota, gasotransmitters, endocrine loops and combinatorial antioxidant strategies.
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约瑟夫
#13
Available as supplements online at many sites.
Been around since 2018, yes 2018
Review
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That page isn’t selling it, it’s just a writeup of some information. You can purchase it on a number of different research chemical websites, but we don’t have enough human data for that to be advisable.
I’d rather put the money I’d take spending on getting this towards a new lifespan study and get more data. This is what I am organizing here. Hopefully the fundraiser is up soon.
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There are places it can be bought. However, as it stands we don’t know much about it. It might be useful and it might not.
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约瑟夫
#16
As I have posted countless times…
“If you wait until you are ready, it is almost certainly too late.”
~ Seth Godin
“I am not the waiting type.”
~Joseph
You can wait.
I purposely did not post a site selling this compound.
It was a article by “Marion Tible PhD a researcher in cellular biology and physiopathology. Formerly a researcher in thematics varying from cardiology to neurodegenerative diseases.”
It is not difficult to locate and purchase this compound
Simple search
FWIW…
2004 patent…
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If you do use it please give as much information as you can on your experience. I am interested to hear it from the perspective of someone interested in longevity.
约瑟夫
#18
Also discussed on this thread…
…
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katiii
#19
I’d love to see lifespan studies on this component too! Any chance this could be done via crowdfunding? A +260% median lifespan extension might be highly unlikely in mammals, but it’s really intriguing. Running a small study could be worthwhile, and the worm bot might be a great place to start.
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So are you willing to put up some cash towards the wormbot. It costs USD400 and USD200 have been promised so far?
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katiii
#21
Yes 
I think we need one more person and then we’re ready to go!
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F it…. I ordered a gram from UmbrellaLabs. Added a gram of ibutamoren to my order and with 10% off from a discount code I found online, another 10% off from orders over $100, and 5% off from paying with a US bank, the total came to $100.58 for them both. Pretty good!
What made me pull the trigger is the batch by batch certificate of analysis. They use mass spectrometry too from an independent U.S. based lab. For details:
I’ll tell you if it feels like anything at all. It’s a gram. Won’t kill me. I’m curious if it does anything. And I’m pretty inured to placebo.
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I’m interested in all user reports at this point due to how little is known on human effects.
Excellent that’s 3 people! I’m just waiting to hear back from Ora about doing the crowdfunding on their website. Might have to wait until the beginning of next month but we will see. As long as people are willing to wait a bit longer then it is ok.
4th person here - happy to contribute US$ 100. I guess that means we’re there? All I need is details on how to make payment to Ora Biomedical…
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Amazing, thank you for supporting this.
I’m going to email Ora again and inform them that we have 4 people willing to contribute $100US each. Maybe they can expedite this before the official launch of the new fundraiser capabilities on their website.
I will report back when I hear more.
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@medaura I’m curious - how will you decide things like how to take it, dosage, frequency etc? Wild-ass-guesses? Or do you have a protocol for how to approach it? Kudos for having a go!!
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I did a Deep Research prompt on ChatGPT to learn more about the substance and it estimated that 5mg a day would possibly be a reasonable dose for humans. Obviously this is not medical advice, or something I can recommend humans do.
If I were to use this substance I would use it in the evening. I suspect combining it with a high dose of melatonin would produce even more favorable effects.
I am incredibly curious on hearing anecdotal reports from longevity enthusiasts who are willing to use the substance.
