#185

Do you consult your doctor on whether or not you should be taking rapamycin?

#186

I look at existing research and decide for myself whether the benefit outweighs the risk. For statins, the benefit definitely outweighs the risk and I’m very satisfied with my current 20mg atorvastatin dose I take daily.

#187

My doctor would not prescribe it off label. The medical profession do not recognise the harm of inaction. (note the word harm rather than risk)

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#188

Alcohol tends to push glucose and hba1c down.

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#189

Good for you; I hope it works out for you.

I don’t know whether the evidence is there that more people hate big pharma than take their meds. Big pharma’s profits suggest otherwise.

The pharmaceutical industry… the research, anyway, has, in my opinion, done the world a lot of good. Arguably, their profit motive could be driving as much harm as good. Plenty of evidence of this, too.

On a personal note, I’m grateful to have made it to 55, am in reasonably good health, might be biologically 44 according to the links above (makes me wonder if rapamycin is worth the risks in my case), and have access to knowledge made available here to improve it somewhat. I’m on no meds, except for my brief experiment now with rapamycin, and my incredibly poor experience with 6 years on statins in my 30s. My CAT score of 19 I drove to zero through fasting. Again, through knowledge gained by learning from people online, through books, etc., etc. I’m a chemical engineer by trade and have a vast curiosity about the world and a thirst for knowledge. By my reckoning, when a person is metabolicaly healthy and eats a species appropriate diet, cholesterol is not a problem.

I look forward to learning more.

I’ll post again in a couple of months after my next blood tests.

I’m still curious as to what specific metrics indicate rapamycin is somehow improving health. I’ve read the studies and Dr. Green’s website. What is the experience and evidence of the group here?

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#190

If they want to keep making a profit, they need to invent stuff that keeps people alive for longer.

I’m a chemical engineer by trade and have a vast curiosity about the world and a thirst for knowledge. By my reckoning, when a person is metabolicaly healthy and eats a species appropriate diet, cholesterol is not a problem.

And there are thousends of doctors and scientists who looked at all available data, ran various clinical trials and came to the conclusion that LDL cholesterol/apoB is to blame for heart disease.

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#191

Great reminder, thank you.

#192

Fantastic results! What’s your diet, % bodyfat or BMI, and exercise regimen?

#193

BMI is 21, diet is much better now than in my youth. I try to stick to unprocessed whole foods. I exercise quite alot. My goal is to do an unassisted muscle-up. Today I did 9 reps (3 sets of 3) with only 19lbs of assistance. I’ve been working on it for about 6 years and I’m slowly getting there, decreasing the assistance a few ounces at a time. We’ll go on trips/vacations that throw me off, but I get back at it. I’m trying to work in more high intensity training for cardio health. Best Wishes

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#194

I assume that you meant CAC (coronary artery calcium) score. How long did it take to go from 19 to zero? And what kind of fasting? Do you still get CAC or CIMT tests to monitor plaque? Do you still fast? For certain people (but not most) cholesterol doesn’t appear to be a problem but it’s unclear why. It doesn’t appear to be diet unless you are really calorie restricted or Keto (and a Lean Mass Hyper Responder).

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#195

Here are my results from my first year. Initially I saw good progress with the Excel calculator, but then I had to take some breaks due to surgery and the flu. It will be interesting to see what happens this year. You can read more about it here. My Results: A Year on Rapamycin

Albumin Creatinine Glucose C-Reactive Protein (CRP) Lympocyte Mean Cell Volume Red Cell Dist Width Alkaline Phosphatase White Blood Cells 年龄 Test Phen Age Calc Notes
mg/dL mg/dL mg/dL mg/L % fL % U/L 10^3 cells/mL years
3/3/2023 4.4 1.04 107 37 91 11.9 44 4.7 49 714 10 mg Rosuvastatin. No Rapa
7/7/2023 4.7 1.21 96 36 90 12.2 49 4.6 49 799 10 mg Rosuvastatin. No Rapa
10/10/2023 4.5 1.31 95 0.4 37.2 91 12.2 42 4.5 49 723 40.96 Baseline. 10 mg Rosuvastatin. No Rapa
2/5/2024 4.8 1.1 97 0.39 39 91 11.6 42 4.1 49 35.5 6-8mg Rapa every 2 wks. 10mg Rosuvastatin
6/21/2024 4.4 1.23 90 91.2 12.3 4.6 50 2 months off due to surgery. 2 wks back on Rapa 6-7mg. 10 mg Rosuvastatin
7/24/2024 4.4 1.21 93 0.52 44 93 12.3 45 3.9 50 41.08 7mg Rapa. 10mg Rosuvastatin
10/25/2024 4.4 1.27 89 0.39 37 93 12.3 43 4.9 50 698 42.33 2 months off Rapa due to illness. No Rapa. 10mg Rosuvastatin
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