#165

I presume your CRP figure is measured in mg/dL. Be careful to put the right units into the calculator. The formula is based on data on a less sensitive CRP test as well.

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#166

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Fifteen years off of my biological age (71-56). My first test a few months ago was 13yrs younger. I worked on my CRP which seemed like a heavily weighted item. Also it looks like albumin is heavily weighted but I couldn’t find any way to raise it other than consuming protein which I already do in abundance. For CRP, I think potassium citrate helped, also had a slightly lower creatinine. My red blood cell geometry has been below the lower reference range for more than a year, but apparently, somewhat below range is actually indicative of greater health. Until I found this out (on my own) I had been concerned about it. My PCP had just waved off my concerns.

I’ve been using rapa monthly 6mg+GF+KitchenSink, but skipped last dose due to dental work. I usually get ulcers. Other proven remedies I use are NAC/GLY (high dose), astaxanthin (100mg/day), ASA (81mg), acarbose (50mg x 2 per day), dapagliflozin (10mg), metformin SR (1g). And for decades now, during the winter, I will take a course of doxycycline or azithromycin just because it seems right, same for occasional fenbendazole, HCQ, and IVM.

I am not recommending any of this to anyone. In fact, I am specifically warning that it is reckless and potentially dangerous, so consult your physician, duh. And it’s not just the potential side effects and interactions, and mis-dosing. Another real hazard is that such poly-pharmacy makes a person essentially a pariah to the medical establishment and health insurance. To gain efficiency in cost, operation, and medical outcomes, they rely on standardized units. Realistically, with poly-pharmacy, there is no way they can effectively and hence ethically treat you. I would do the same if I were in their shoes, but I’m not. I’m just struggling to survive and prosper. Attached is the full lab report to show my bona fides. The names have been redacted to protect the guilty.

Oh my lipids look crazy good, check them out. I don’t know how to explain this to my PCP. I go in every year or two. He knows I’m taking a statin from decades ago, so I’ll just say that now I’m taking the statin regularly every day and that, plus prayer, great diet, sleep and exercise have done the rest. He might buy it, idk. That’s my story and I’m sticking to it.
Sept24redacted.pdf (1.2 MB)

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#167

Kudos to your excellent results. I see nothing wrong with your protocol.

#168

How do you have so low lipids?

#169

Although I was first prescribed statins decades ago, I would take them irregularly. I started thinking how most of the men in my family have died, and it’s CVD, so I had to get serious: so rosuvastatin 20mg, Ezetimide 10mg, B3 500mg. The LDL reading from 2 months ago came in at 78 after a month of steady 20mg Rosuvastatin, then I added the Ezetimide which got me to the present 40. It could be too low, although my understanding is that 20 is the danger zone, and I’m at 2x that, so idk.

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#170

Good watch-out, thank you.

#171

Check out all the science Marion Holman links to on X. You’ll re-think your use of statins…

#172

40 should be fine. My target zone is 30-50 for LDL and ApoB. For me, it is 48 for both when I use 5 mg Atorvastatin, Bempedoic Acid and Ezetemibe.

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#173

Over the past 30 years, I have been on and off statins perhaps a dozen times. I’ll be on them, then read what seems to be convincing negative evidence, so I’ll quit. Then a year or two later, I’ll read things that convince me they are a net positive, so I’ll start again, which is the current phase. I cannot swear, and indeed it is in fact likely (given my history) that I will change my mind yet again sometime in a year or two. So, as always, in the final analysis, IDK! (I just stumble through this foggy alien forest as best I can.)

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#174

The evidence in favor of statins is clear. You should look up the pyramid of evidence and ignore observational studies, ““expert”” opinions and anecdotes in favor of intervention trials and systematic reviews that all show a clear benefit of statins.

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#175

Or just go with Bempedoic Acid and Ezetemibe. No statin problems.

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#176

@DeStrider I agree, Especially for people who have known side effect with statins. Why suffer needlessly when other tools are available? No reasonable person says statins don’t lower apoB or that apoB doesn’t matter at all. But statins do have side effects as do all drugs. When the side effects are severe enough it is worth investigating other solutions.

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#177

I humbly disagree. Check out the X account I referenced. You’ll find plenty of links to studies detailing the disruption of the mevalonate pathway that’s critical to maintenance of the myelin sheaths of the nervous system… and the ensuing muscle pain and neurological degeneration leading to dementia that ensues when statins are used long term.

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#178

I do appreciate the discussion… and I’m forever curious, so I’m open to other sources of info.

#179

A random X account does not supersede systematic reviews.

You’ll find plenty of links to studies detailing the disruption of the mevalonate pathway that’s critical to maintenance of the myelin sheaths of the nervous system

Those are called mechanistic studies and, even assuming they are not based on fraudulent data and misrepresentations, can be safely ignored if they don’t cause issues in-vivo.

and the ensuing muscle pain and neurological degeneration leading to dementia that ensues when statins are used long term.

Luckily we have long term data on statins showing a neutral to beneficial effect on dementia rates and no particular issues in the vast majority of statin users regarding muscle pain. In some cases, CoQ10 supplementation can help in the users who do get side effects.

You should take a look at the pyramid of evidence. If everything mechanistic pathway led to clinical outcomes, microplastics would’ve killed you already.

#180

I double checked the units. All seem correct. I don’t believe the units for Albumin in the excel spreadsheet are correct. If I adjust for units (4.4 g/dL to 4400 mg/dL), the spreadsheet breaks. 4400 mg/dL also doesn’t make sense.

The CRP units are correct (mg/L). I’ll have to get a high-sensitivity CRP test next time around.

I’m in the process of dropping weight… I was 218 back in June, down to 210 now, and I’m targeting 190. Need to get my glucose down from 99, and I’ve not been exercising, so I’ll get back on that wagon, too.

I started rapamycin two weeks ago. 1mg the first week, 2mg last week, and this next week I’ll bump up to 3 mg and maintain it there for a few months.

Thanks, John_Hemming, for the feedback and thoughts. You were spot on.

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#181

The “random” X account links to scores of studies from well known sources. Check it out before dismissing it. That’s not the only source, it’s just a good one. Let me know if you’d like me to start sharing links to some of those studies.

The information is there. This group is already deviating from “main-stream” medicine. By pushing back/sharing what I’ve learned and experienced first hand, I’m hoping to at least spark a little curiousity.

It’s all good stuff, do with it what you will.

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#182

Even if they are, they are still mechanistic studies and as such superseded by actual outcome data.

Let me know if you’d like me to start sharing links to some of those studies.

Unless they are systematic reviews and intervention trials, I’m not really interested.

This group is already deviating from “main-stream” medicine.

That’s called a conspiracy group and there are plenty of those on social media and youtube.

By pushing back/sharing what I’ve learned and experienced first hand, I’m hoping to at least spark a little curiousity.

There are more people who hate on Big Pharma and modern medicine than there are people who take their medication.

#183

Wow, great catch, the albumin units are off. I’ll double check them. The spreadsheet I have is editable so I could have screwed it up. The CRP blood test reading just gave less than 15 so I chose 14 to be conservative.
I was using the xls that RapaAdmin posted. I think the units are off in that posted xls attachment. On my previous test I had doubled checked it with an online Levine calculator and they pretty well agreed, so I think the numbers are good. I alerted RapaAdmin to the possible unit mis-labeling.

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#184

I’m excited to see my “biological age” is 44. It’s encouraging to play directly with the spreadsheet to tweak what’s in my control. I suspect my elevated blood glucose is from alcohol consumption. I’m now three weeks dry, and intend to maintain that status at least until my weight is at target (also assuming I maintain my moderate muscle mass). This is fun and very motivating!

What should one expect to change or “improve” with rapamycin use?

At some point I’ll pony up the $$ to do a proper epigenetic test a la Bryan Johnson and David Pascoe. I’ve probably abused my body too much over the years to expect to see their results. I’ll take what I can get!

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