#1

I’ve just completed my first year on rapamycin and wanted to share my results. I’m posting my logs and blood test below.

A couple of takeaways:

  • I took rapa every other week.
  • Lipids - I saw no negative effects on lipids. I take 10mg rosuvastatin.
  • Glucose - No effect on HbA1C. It was more correlated to how often & hard I workout instead of rapa.
  • RBC, Platelets & Neutrophils - these all clearly improved while on rapa vs not.
  • I had two extended breaks during the year. Once in the spring with a gap of 2 months due to a surgery, and 2 months in the fall due to the flu. Sadly, I was just about to get my flu vaccine when catching it.

These are all encouraging results. No drift in lipids or glucose, and improvements in RBC, platelets, and Neutrophils. I hope to be more consistent this year.

Year_1_Results.pdf (427.8 KB)

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A Friendly Biological Age Reduction Competition?
What are your triglyceride/LDL/LDL particle sizes/VLDL levels, did they change with rapamycin use?
#2

Nice job on the documentation. Your results are consistent with what I see in the majority of my patients.

I’m curious on the mg you were taking each dose as I don’t see that listed.

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#3

Thank you. The rapa mg dosing is in the first column. I was taking 8mg, but was getting slight headaches, so I reduced to 7mg and for the most part have not had any headaches. No other symptoms.

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#4

Is that with GFJ? Do you ever do a blood test?

#5

I never took it with grapefruit. I did usually take it with salmon or avocado oil, and occasionally green tea.

I did a blood test after taking it with salmon and it essentially mirrored the standard curve.

2/3/24 Sirolimus blood test: 4 ng/ml at 43 hours after dose. >1.2 ng/ml 7 days after.

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#6

Interesting, which brand of rapamycin did you take? I took Zydus 8mg 3 hours after meal and GFJ 2 weeks ago. My 84 hour blood test got a score of 13ng/mL. This week I took 4mg. Just had my 24 hour blood test. Next one will be at 72 hours.

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#7

I’m assuming you were taking the statin before starting the Rapa?

#8

I take Zydus. 8mg + GFJ will definitely increase your blood concentration. Since we don’t have any data on these super high doses I’ve just been doing it without GFJ.

#9

Yes, I started the statin before Rapa.

#10

I weigh about 110kg so generally I’ve to take more to reach the minimum targetted concentration.

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#11

It’s great that you’re tracking your markers longitudinally! I’d switch over to this spreadsheet, which has the added benefit of computing your levin phenotypic age.

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#12

Great spreadsheet @Gokhan , thanks for sharing!

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#13

What is the best formula for phenotypic age calculation please?

#14

Appreciate that. I’ll take a look!

#15

Morgan Levine at Yale University (now she’s at Altos Labs) created what we call the Levine Phenotypic calculation. See this thread with links to the paper: A Friendly Biological Age Reduction Competition?

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#16

The latest result shows that I probably should reduce my rapamycin to 2mg + GFJ. Should give me more than 3ng/mL after day 3. And maybe move to a weekly or 10 day cycle instead of fortnightly.

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#17

Thanks for the formula, RapAdmin!