#184

Any reference information show benefit in ITP with Estriol ?

All the benefits I know now are about 17 α-Estradiol with male.

#185

See this thread:

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#186
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#188

I found commercial forms of estriol include creams and tablets. I found these drugs manufactured in India. Are they the same molecules which have been tested in ITP ? Thanks

Cream: Evalon Estriol Cream, 15 g at Rs 509 in Nagpur | ID: 2853285190233

Tablet: Estriol Evalon 1mg Tablet, Prescription, Harmone Replacement Therapy at Rs 152/stripe in Nagpur

#189

Yes it’s the same, I don’t know the dosing or anything else.

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#190

Does anyone has exams pre and post usage of alfatradiol on hair? Really want to see the degree of systemic absorption. I used it myself back in 2016, but at that time I didnt measure the hormones. Now it is harder to find in my country

#191

Do you mean measuring systemic absorption by checking 17-alpha estradiol? Anyway, there is a company (apohealth.de) I know that ships this out of Germany worldwide:

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#192

Actually by measuring 17b-estradiol and testosterone.

I’ve seen some studies (in monkeys) showing that alfatradiol may enhance 17b estradiol production and lower the T levels. But it was high dosage and orally, they have never made good studies on topical usage with low doses like 0.75mg. The study on monkeys were like 15mg orally.

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#193

Just to clarify - are people here mixing this with transcutol and applying to the skin with a dropper for systemic absorption? Any noticeable effects?

#194

The one I posted is premixed.

#195

Doesn’t look like it’s mixed with transcutol though

#196

From a chemical data sheet, looks like DMSO and ethanol are solvents for our new best friend:)

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#197

It’s been about a year and a half since DrEcsta gave a report on his use of 17 Alpha Estradiol. If anyone knows how to contact him let me know. I want to hear more about his story.

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#198

Have members been using the 17-alpha estradiol serum in their hair on a daily basis? Any changes in hair density? Wondering if it could have effects (in a female) if you don’t experience thinning yet, and still have a scalp full of hair (knocking on wood).
Does application result in greasiness? (Can’t wash scalp too often as mentioned, because of fine hair and lots of knots to detangle if I do). Thanks!

#199

As someone who used alfatradiol in the past, it didn’t help as a mono-therapy treatment nor did it help when used in conjunction with finasteride. I once emptied half a bottle on my head out of frustration and my breast tissue hurt that day. On the upside, it does not leave your hair greasy like topical minoxidil would.

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#200

Thanks so much for sharing, that’s helpful - albeit a pity to hear. Sorry to hear it didn’t work for you.

:grin: I can totally see myself doing the same thing. It does seem to indicate some potential systemic absorption, albeit likely minimal at ‘normal’ doses.

#201

I’ve been trying the transdermal route for 17ae2 for the last few weeks (alfatradiol + transcutol) and just had my blood drawn.

Estradiol sensitive came back high at 37.8 pg/ml, where the reference range indicates above 35pg/ml is high for a man. This is up from my previous result of 29 pg/ml six months ago. So leads me to believe the transdermal route is working.

Prolactin was low, just outside the reference range. No real change in IGF for me.

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#202

What dose of 17-alpha estradiol and what ingredients exactly did you use, if I can ask? (Was it just transcutol + 17 alpha-estradiol, without any other ingredients that further enhanced absorption?)
This makes me reconsider, as I had considered using the 17-alpha-estradiol for my hair, but I wouldn’t want to potentially affect my estradiol levels.

#203

It’s the Ell-Cranell Alfatradiol 250mcg/ml. I mixed with 25% transcutol and applied 2.5ml to forearm area. This should be 500mcg per day or 3.5mg/week, so close to what Bryan Johnson is doing (4mg/week)

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#204

Any idea on the basis for that dose level? Is the 4 mg/week estimated to be longevity dose?

Do you apply it to the outer or inner forearm? Have you noticed any effects on forearm hair growth at all?