My view FWIW is that delaying menopause requires much the same things are delaying any other form of aging.
Rapamycin as part of this is about improving mitochondrial quality, but it has side effects. The side effects are minimised in part by not taking it every day (as well as limiting the dose).
Hence rather than take a bit every day then stop for a rest, take it infrequently. However, that is not medical advice and each person is different.
However, also Rapamycin is only one tool for improving mitochondria. It is worth using a number of tools for these things.
Also I think the benefit of Rapamycin on mitochondrial is strongly linked to the peak serum concentration.
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A disappointing update on Oviva Therapeutics:
And some interesting news that is more positive:
It should be said that there is already a company in the UK offering a medical intervention to delay menopause. ProFam offers clients the chance to remove some healthy, young ovarian tissue and freeze it. When you defrost it and graft it back into the body, it can restore hormonal function, and possibly egg production, says Melanie Davies, consultant obstetrician and gynaecologist at University College London Hospitals NHS foundation trust, with special interests in gynae-endocrinology and fertility preservation. “We’ve been doing it for quite a while for young women with cancer.”
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AnUser
#187
I predict a MASSIVE trend where young women start taking Rapamycin.
#TikTok
Just Take Rapamycin And Chill
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Yes - I suspect this may be the tipping point for longevity use of rapamycin.
AnUser
#189
The infrastructure is already in place for U.S women to order from India, no real bottleneck. Just need a rapa memetic virus that will spread throughout the universe. Even if rapamycin had a small effect or even no effect which I doubt then it lays the foundation for Longevity Drug Thinking.
This is only going to happen if people start putting effort to it, though. It will be a medical coup d’état destroying all frauds, fake supplements, and treatments without promise… The first thing someone will eventually ask: Did it improve mice lifespan?
We need Rapa Influencers. Women take your chance!
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RapAdmin
#192
Listen to the podcast here:
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RapAdmin
#193
Video of the above podcast, queued up to the start of the rapamycin discussion:
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Kay_Qds
#194
Hello there. I am a female, 36y, Amh 2.321. I have started taking Rapamycin 3 weeks ago( 5mg a week) .
I will be following up the natural decline of my Amh to get an ideea if Rapamycin is making any diffetence.
SO FAR absolutely no side effects
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I think there is an issue of mitochondrial quality within the Oocytes. I don’t know if rapamycin helps with this, but I think it needs to.
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So Aimee herself is taking rapa indefinitely to delay menopause. She says there is a difference in her fertility patients around 2 months but I wonder if they are at 5mg or 2.5mg weekly. Does anyone have further details?
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Kay_Qds
#198
If Rapamycin is taken continously, i guess there could be as it would totaly alter ovulation. But if taken for 12 weeks either once or twice a year with breaks in between, i think that would give the max benefit. I an just speculating, i am not a doctor and this is all experimental at my own risk.
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Kay_Qds
#199
She starts them at 5mg and lowers to 2.5 if side effects are unbareable
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However, in mammals oocytes are intially generated within the embryo and kept quiescent which avoids metabolism. It is the older eggs that fail to generate embryos. There is good evidence this relates to difficulties with mitochondrial quality.
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Kay_Qds
#201
What is your take on this? Would rapamycin be able to help quality of ocytes?
I don’t know. The problem is that the rapamycin may not get to them. Its an interesting question. It may be that targeted PEMF might do the job.
What is very clear is that older women can give birth to children with donated eggs. Hence the metabolism of the eggs is an important issue.
If Rapamycin gets to the eggs and causes improvements in mitochondrial quality then perhaps that would help.
In the end, however, a proportion of eggs may have sufficient mitochondrial quality. Hence it is the number of fertilisations that is key.
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Kay_Qds
#203
Well
I guess end of the day it only takes one good egg . Although women in their 40s do have a high number of eggs with chromosomal abnormalities, some will still be healthy. So i guess the whole point is to increase overall no of eggs available…i really dont know. For oocyte quality lifestyle factors , diet, no smoking, suplements such as omegas3s and cq10 do seem to do the job.
Ludovic
#206
In this study an oral micronutrient preparation (omega-3 fatty acids, coenzyme Q10, vitamin E, folic acid, selenium, catechins and glycyrrhizin) daily for 6 months have hopefull results:
Preconceptional micronutrient supplementation and spontaneous pregnancy rates in women of higher reproductive age and unexplained infertility: A comparative study
https://www.sciencedirect.com/science/article/abs/pii/S0210573X24000510
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