Do you know when in your rapamycin cycle that you took the estradiol test?
For example, most of us here take rapamycin on a weekly schedule. If the day you took the estradiol test was the day after your rapamycin dose it might be very different than if you took the estradiol test 6 days after dosing rapamycin because rapamycin typically has a pretty long half-life of around 63 hours.
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Senben
#176
I didn t know that. Thank you for telling me.
Yes, I took Rapamycin approximately 36 hors before I measured Estradiol.
Maybe I should do another Estradiol test next week but I will not take Rapamycin approx 4 days before taking Estradiol test,
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Sirt6
#177
Dear fellow women,
I’ve been on Rapamycin for 2 years now with no adverse effects. For contraception, I’m using a copper IUD. It’s now time to replace the device, so I did some research on what’s new on the market.
Problem: A copper IUD activates immune cells within the uterus, which is part of how it works. Sperm and possibly fertilized eggs are partly hindered by this immune activation. Anyone on immune suppression or medication for rheumatoid diseases should not rely on copper IUDs.
In addition to the inflammatory response, copper ions from the copper IUD hinder sperm, prevent the build-up of the uterine lining, and inhibit the implantation of a fertilized egg.
I’m sure there isn’t any data on anti-aging doses of Rapamycin combined with copper IUDs. We certainly shouldn’t increase the dosage to a point where mTORC2 is suppressed.
Worst case: I don’t know if it’s possible to become pregnant if ovulation has just occurred, Rapamycin is taken nearly at the same time, and sperm enters the uterus. I also don’t know, if the lokal immune activation near the Cu IUP follows a curve when combined with rapamycin for anti aging.
Any thoughts?
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Senben
#178
Just wanted to report that I took another Estradiol test after skipping weekly Rapamycin dose and Estradiol was in normal range. It seems that Rapamycin just delayed my cycle a little bit.
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It seems that if rapamycin does in fact delay menopause it would help with reducing risk of dementia:
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The New York Times covering this area now: Is Delaying Menopause the Key to Longevity? (NY Times)
In the article, they state that in the Columbia University study they are tracking AMH hormone levels in women (available in most areas via an inexpensive blood test as described below) to track effectiveness of rapamycin as an intervention in this area.
For women taking rapamycin for improved fertility or menopause prevention it seems like we may be table to track if its working by monitoring AMH levels. Please consider taking the AMH test and please also report back your results. This way we could get some early indications of how well its working and not have to wait for the next few years while Columbia University completes its research and publishes the results.
A clinical trial currently running at Columbia University is also trying to slow the rate at which women lose their eggs. The study is testing the use of an immunosuppressive drug called rapamycin — which is used to prevent organ transplant rejection and has become a darling of the longevity movement — in women between the ages of 35 and 45 to see how it affects their ovarian reserve. Rapamycin influences the number of eggs that mature each month, and the drug has been shown in mice to extend ovarian function.
The study is still ongoing, and the researchers don’t know which participants received the medication or a placebo, but the lead scientist on the trial, Dr. S. Zev Williams, said that two patterns had already emerged: Some women appear to have a normal decline of ovarian reserve, which can be measured via ultrasounds and AMH levels, but in others, “it seems to have been altered,” he said. “So, you know, that’s promising.” Dr. Williams, an associate professor of women’s health at Columbia, is also applying for the health agency funding.
The experts were explicit that the goal of this type of research was not to prolong women’s periods indefinitely, nor to make pregnancy possible at age 70 — though the treatments could potentially extend fertility.
Read the full story: Is Delaying Menopause the Key to Longevity? (NY Times)
AMH Levels with Age:
it would be really interesting to know if (if you ever do this testing) how your AMH levels compare to the typical trendiness for females (see following graph). If we see significant outliers in the rapamycin group (higher than expected) it would be a very good sign that rapamycin is doing what we think it should be doing.
| AMH levels according to age for women 24-50 years of age. Median values are shown with standard deviations. Reproduced with permission from Seifer et al. Age-specific serum anti-Mullerian hormone values for 17,120 women presenting to fertility centers within the United States. Fertil Steril. 2011; 95 (2): 747-50.
Mean values of AMH of three different tests as a function of age. We can see the decrease in the mean values of each consecutive test placed on the market.
Source: https://www.researchgate.net/figure/Mean-values-of-AMH-of-three-different-tests-as-a-function-of-age-We-can-see-the-decrease_fig2_261746114
How to get an AMH Test
Just order it online (if its available in your area) then go to the LabCorp or Quest facilities to get the test done. Its quite inexpensive. (check to see if which lab the online service uses to fulfill the blood draw, make sure there is one in your area).
Marek: $65
UltaLabs: $87 at current listing
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Hello. According to the Vibrant study, to delay menopause, 5 mg should be taken every morning for 3 months.
Is it advisable to rest for how long after that period?
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Hi Victoria, welcome to the site.
We really don’t have good data on if a break should take place, or how long. One factor to consider is how your body is processing the rapamycin. You can take a rapamycin blood level test (on the last day before you take your weekly dose) and check to see what your blood-sirolimus level is. If you still have a meaningful (i.e. over 1ng/ml) level of sirolimus (rapamycin) in your blood then it may be that you are not fully clearing rapamycin from your system each week (in which case a break for a number of weeks may not be a bad idea).
I recommend you review these threads as part of your decision making process:
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My view FWIW is that delaying menopause requires much the same things are delaying any other form of aging.
Rapamycin as part of this is about improving mitochondrial quality, but it has side effects. The side effects are minimised in part by not taking it every day (as well as limiting the dose).
Hence rather than take a bit every day then stop for a rest, take it infrequently. However, that is not medical advice and each person is different.
However, also Rapamycin is only one tool for improving mitochondria. It is worth using a number of tools for these things.
Also I think the benefit of Rapamycin on mitochondrial is strongly linked to the peak serum concentration.
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A disappointing update on Oviva Therapeutics:
And some interesting news that is more positive:
It should be said that there is already a company in the UK offering a medical intervention to delay menopause. ProFam offers clients the chance to remove some healthy, young ovarian tissue and freeze it. When you defrost it and graft it back into the body, it can restore hormonal function, and possibly egg production, says Melanie Davies, consultant obstetrician and gynaecologist at University College London Hospitals NHS foundation trust, with special interests in gynae-endocrinology and fertility preservation. “We’ve been doing it for quite a while for young women with cancer.”
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AnUser
#187
I predict a MASSIVE trend where young women start taking Rapamycin.
#TikTok
Just Take Rapamycin And Chill
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Yes - I suspect this may be the tipping point for longevity use of rapamycin.
AnUser
#189
The infrastructure is already in place for U.S women to order from India, no real bottleneck. Just need a rapa memetic virus that will spread throughout the universe. Even if rapamycin had a small effect or even no effect which I doubt then it lays the foundation for Longevity Drug Thinking.
This is only going to happen if people start putting effort to it, though. It will be a medical coup d’état destroying all frauds, fake supplements, and treatments without promise… The first thing someone will eventually ask: Did it improve mice lifespan?
We need Rapa Influencers. Women take your chance!
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RapAdmin
#192
Listen to the podcast here:
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RapAdmin
#193
Video of the above podcast, queued up to the start of the rapamycin discussion:
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Kay_Qds
#194
Hello there. I am a female, 36y, Amh 2.321. I have started taking Rapamycin 3 weeks ago( 5mg a week) .
I will be following up the natural decline of my Amh to get an ideea if Rapamycin is making any diffetence.
SO FAR absolutely no side effects
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I think there is an issue of mitochondrial quality within the Oocytes. I don’t know if rapamycin helps with this, but I think it needs to.
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