Just a side-note to be aware of. Egg freezing is definitely an option, but some people think its a guaranteed pregnancy later, but the success goes down relatively quickly it seems:

Elective oocyte cryopreservation involves controlled ovarian stimulation with injection medication and ultrasound-guided egg retrieval. The retrieved eggs are then stored in the fertility clinic. The procedure is expensive, as total costs range from $9000 to $17,000 per cycle with an additional $300 to $500 annual storage fee.

However, freezing eggs does not guarantee future live birth. Research suggests that women under 35 with normal ovarian reserve have the highest chance of giving birth using frozen eggs.

An earlier study of 645 women who chose elective oocyte cryopreservation found that only 54 (8.4%) used their frozen eggs during the 18 years period. Among women who did, 17 (31.5%) achieved at least one live birth. The birth rates were the highest among women aged 35 and younger (63.6%), compared to those 36–39 years (42.3%) and women 40 years and older (17.6%).

Source: https://healthnews.com/news/most-women-do-not-use-their-frozen-eggs/

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Thanks for the reply - I’m definitely aware of the low incidences of live births from frozen eggs. It’s a tricky decision because if you choose not to, and later face infertility, you’re always going to wonder if you should have pursued it. It’s an industry built on fear. But most women that do freeze eggs never use them because they end up conceiving naturally when they’re ready.

It does seem like Rapa is a promising alternative.

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Another article that touches upon this thread’s discussions:

Here: A guide to extend longevity by delaying menopause (Age1)

So when attempting conception stop rapa 6 weeks before? What about the male? Does it affect sperm quality? Do we know?
Thanks!

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On the Mayo Clinic website they say:

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant, and keep using it for at least 12 weeks after you stop taking sirolimus. (source).

Related: Sirolimus Used During Pregnancy in a Living Related Renal Transplant Recipient: A Case Report

As far as males go:

Conclusions

This survey does not provide any warning signal that pregnancies fathered by male patients exposed to immunosuppressive agents, notably the debated MMF/MPA, have more complications than pregnancies in the general population. (Source)

And, a recent video from the researcher focused on this area:

Yousin Suh, who researches reproduction and genetics at Columbia University, describes research showing that the organ transplants and anticancer medication rapamycin may also be able to extend lifespan. Su and her team have commenced a clinical trial called VIBRANT, for Validating Benefits of Rapamycin for Reproductive Aging Treatment, to study whether rapamycin can slow the aging of human ovaries and delay the onset of menopause.

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Thank you! Any thoughts on Methylene Blue in regards to conception/pregnancy - how far in advance to stop? Can’t find much info beyond that it’s shown to have a half-life of 5-6 hours (max 24 hrs)… BTW, back to fertility on Rapa, my N-of-1 definitely shows great improvements towards youthful cycles after year+ of 6mg/wk.

Causes birth defects. Stop right away if you’re pregnant.

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Thanks. I meant when trying to conceive as well?

Not sure. I was taking it here and there right until I got pregnant

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Thank you! All is going well? Congrats!

Another strategy, presented by AthenaDAO at Vitalia:

Related:

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Thank you, all’s well so far, I was nervous re: abnormalities given mg crazy stack at the time but all looks good so far! Now I’m taking choline, fish oil, hyaluronic acid, prebiotics, and occasionally collagen powder on top of my prenatals.

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Yes but this requires a time machine as well for 99% of us to be relevant. Perhaps for our daughters it might become an option though.

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Great! And I hear you… I’m v nervous too (in advance). Which powder is the cleanest? Dr Rhonda Patrick said she stayed away even from collagen during pregnancy to avoid any impurities.

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I honestly didn’t go down the rabbit hole of researching the cleanest powder. Got the one with the best reviews but don’t take it daily because I don’t love the taste it creates with milk. I figure though there’s no point in getting anal retentive with every source of possible contamination. Sadly there’s guaranteed to be microplastics in the placenta and breast milk — what am I to do? There’s inadvertent exposure to things we don’t want happening all around us. I just try to eat well and I use a reverse osmosis water filter too and leave the rest to chance.

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A new paper out of McGill University in Montreal (actually the university that led the expedition to Easter Island that discovered Rapamycin).

several unproven IVF ‘accessories’ have emerged including so-called ovarian rejuvenation which entails placing fresh autologous platelet-rich plasma (PRP) directly into ovarian tissue. Among cellular responses attributed to this intervention are reduced oxidative stress, slowed apoptosis and improved metabolism. Besides having an impact on the existing follicle pool, platelet growth factors might also facilitate de novo oocyte recruitment by specified gene upregulation targeting uncommitted ovarian stem cells.

this proposal is the first to discuss intraovarian platelet cytokines followed by low-dose, phased rapamycin. For refractory cases, this investigational, tailored approach could amplify or sustain ovarian capacity sufficient to permit retrieval of competent oocytes via distinct but complementary pathways—thus reducing dependency on oocyte donation.

Given that intraovarian injection of PLT growth factors can increase serum AMH (indicating expansion of the follicle/oocyte unit) [7,77] and mTOR inhibition has been suggested to boost ovarian reserve [78], a bespoke protocol incorporating both might provide a useful synergy.

Open Access Paper:

相关:

Rapamycin improves the quality and developmental competence of in vitro matured oocytes in aged mice and humans

After intracytoplasmic sperm injection (ICSI) and further culture of human oocytes, the high-quality embryo rate in the rapamycin group was significantly elevated. Overall, rapamycin improved IVM outcomes of oocytes from aged mice and older women. The specific mechanism of the positive effects of rapamycin on IVM outcomes might be reducing ROS levels, mitigating DNA damage, and promoting developmental potential.

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In the study involving mice, they found that spermidine levels in aging ovaries decline, leading to lower egg quality. However, supplementing with spermidine in mice increased spermidine levels, improved egg growth and enhanced fertility.

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A new story about the rapamycin / menopause study at Columbia University:

Williams is leading a study to understand the impact of slowing ovarian age on women’s health. The double-blind study looks at 100 women between 35 and 45 who have normal periods. (Double-blind means no one knows who receives the treatment and who receives the placebo.) Subjects are randomized to receive either rapamycin or a placebo. For three months, participants take a pill, and researchers will follow them for another nine months.

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Hi! I started taking Rapamycin one month ago, 4mg weekly, as I am traying to delay menopause. I am 49 years old with more- less regular cycles. After taking Rapamycin for one month I measured my hormones and found out that my Estradiol levels are low. Could it be that Rapamycin suppressed my Estradiol levels as my body thinks that I am in deep autophagy (something similar to Calore Restriction so my body thinks there is no enough food and that’s the reason my body don’t produce enough Estradiol)? I read on this page about woman taking Rapamycin and having more regular cycles. Does it mean that more regular cycles could be achieved after taking Rapamycin for for example 3 months and than stopping taking it all together so that body doesn’t think it is in autophagy or one can get more regular cycles taking Rapamycin regularly (once per week)? Thank you

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Hi, and welcome to the website.

So - you did your Estradiol test After taking rapamycin for a month, but did you have any measures of your estradiol level before taking rapamycin?

I have not read deeply on the issue of impact on rapamycin on estradiol to know the exact impact. If someone else here has, please add your thoughts.

The research on rapamycin’s effect on fertility & menopause in humans is still in its early stages, so the short answer is we don’t know about the need for continued dosing. But in all the animal studies I’ve seen you generally see either continuous (daily) or pulsed (e.g. weekly) dosing ongoing over the lifespan if you want to keep seeing the benefits. There is some indication that people might be able to do dosing for a while, then take time off from dosing, and may still see the benefits. For example in some animal studies (on longevity, not on menopause or fertility) that I’ve seen, the dose for a few months, then they pause for a few months, etc. and the benefits continue for many months afterwards. But the first real study in humans as it relates to menopause has just been started at Columbia University Medical School and we won’t know the results for perhaps a few years. So its all still very early.

There are some good reports from people as can be seen in this other thread on the topic:

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