eg https://onlinelibrary.wiley.com/doi/10.1111/acel.12943
We show here that mTORC1 signaling is activated in a subset of skeletal muscle fibers in aging mouse and human, colocalized with fiber damage. Activation of mTORC1 in TSC1 knockout mouse muscle fibers increases the content of morphologically abnormal mitochondria and causes progressive oxidative stress, fiber damage, and fiber loss over the lifespan.
kaeberlein also mentioned it in the IL11 optispan podcast (IL11 antibodies help negate that increase)
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