#164

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Yes, it is a little confusing. I will look into it.

It might be just one of those things affected by the FDA
“Levocarnitine is also available over-the-counter as a supplement. The OTC version is more commonly known as l-carnitine and it isn’t FDA-approved to treat the same conditions as prescription levocarnitine (Carnitine).”

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#165

Here is a lifespan study that tested Lovaza and krill oil in long-lived mice. It may have slightly reduced lifespan. It was one of the Spindler studies. This researcher also tested supplement mixtures that failed to extend lifespan or maybe shortened lifespan.

Spindler also published a paper suggesting that a list of positive murine lifespan studies using various compounds were likely the result of calorie restriction instead, otherwise the researchers would have given information as to how they maintained similar calorie consumption between control and experimental groups. This bothered me a little. It seems like a very bold statement to make. I recently posted a study from another team that tested a mixture of familiar supplements that significantly extended lifespan. I don’t discount his work. But I’d like to see confirmation from other researchers.

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#166

Here is a rat lifespan study using marine collagen peptides. It increased both mean and maximum lifespan.

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#167

Thank you! Spindler does great work!

This is the one I was using.

https://www.iherb.com/pr/california-gold-nutrition-antarctic-krill-oil-omega-3-phospholipids-complex-with-astaxanthin-natural-strawberry-and-lemon-flavor-1-000-mg-120-fish-gelatin-softgels/71631

Spindler dosed the mice at 124 mg/kg body weight per day. My dose turned out to be 21.6 mg/kg.

Maybe a modest quantity of algae-based EPA would be a better choice. I am not sure. If I remember correctly, Gil Carvalho is taking vegan EPA to hedge his bets but he isn’t sure about it.

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#168

If I were on a carnivore diet like OP, I would consider taking a fiber supplement such as inulin or psyllium and sustained release vitamin c as well. There may be other micro-nutrients that are harder to maintain at optimal levels on a carnivore diet, but those are two that come to mind.

On the other hand, I would be less worried about supplementing creatine, carnosine or carnitine on a carnivore diet.

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#169

Any updates on how it’s gone/is going to optimize your DHEA levels?

#170

I know ubiquinol is a mixed bag in terms of study results but personally it seems to really help with the side effects from moderate to high dose rosuvastatin. No more muscle issues whatsoever. Even just 30mg seems to do the trick but I’m planning on taking between 100mg and 200mg per day from now on. It can’t hurt in any case (except my wallet of course).

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#171

Any references to support this?

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#172

Surprised i don’t see a lot of people taking L-lysine daily. Being that is so important in healthy aging especially bone and muscle health, would have thought it should get a lot of attention. I make sure I get 3gr daily with 3gr of vitamin C. I think a MUST to maintain strength and posture. Dirt cheap on amazon and elsewhere, $50/year

Amazon.com: Nutricost L-Lysine Powder 1KG (2.2lbs) - Pure L-Lysine, Non-GMO, Gluten Free : Health & Household

Amazon.com: PURE ORIGINAL INGREDIENTS Vitamin C Powder (5 lb) Ascorbic Acid, Non GMO, Dietary Supplement : Health & Household

What Is L-Lysine Good For? 10 Health Benefits & 10 Best Food Sources (medicinenet.com)

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#173

An easy way to get it is in whey. I get 8 grams daily from my protein shake that I take daily in order to stave off sarcopenia.

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#174

I know some essential amino acid restriction is inline with longevity and recapitulates much of calorie restriction benefits without restricting total calories.

Seems like most of the studies have been on BCAAs in that regard. But could it be that L-lysine is something don’t want to keep boosting throughout like if longevity is the goal?

One might still want to increase it later in life when succeeding with muscle maintenance is more important/challenging, but perhaps not in middle age or younger years?

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#175

This does make sense, but for an older guy (57 that feels like 35) like me I think it is very important to keep my muscles and bones strong. I still climb two stairs at once at my job (couple flight of stairs) with no problem whatsoever even though I barely exercise other than do some heavy weights, and resistance springs for my shoulders.

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#176

:ok_hand:

Perhaps try to find some ways to get in more resistance training since it might help achieve your bone and muscle goals in the long run more than extra amino acid supplementation alone - best results prob with the combination

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#177

While I’m big on anti-aging stuff, not a big fan of extensive training, other than 10–15 minutes of intensive training/heavy lifting. I have yet to find a bodybuilder that has lived past 80 (I’m sure there could be some, but not very many) and I know a couple guys that never did any exercise other than maybe couple miles of walking and they are well into their late 90’s. For now, I have no plans in taking your advice of heavy exercise. I do however intend to take up yoga in next year or so. will see how it goes, and yes, I will continue taking 3-4gr of Lysine and 3-5 gr of VitC daily as I did order my one-year supply of both for only $80

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#178

Better to burn out than fade away, fading away is the worst thing about again IMHO healthspan over lifespan

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#179

That’s why I’m doing the lysine to keep my bones and muscles strong and healthy. No fading away for me so far. at 57 same exact body mass and same exact height. Many of my same age friends have already lost about an inch of their height.

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#180

There’s a big difference between a guy who lifts “hard” (45-60 minutes, 2- 3X/wk) and a body builder/powerlifter. Unless you intend to get as big (muscle) as you can (which will take a very long time), don’t be frightened of short lifespans for bodybuilders. Historically they won’t do any endurance exercise for fear of “interference effect”), they develop heart issues from repeated high blood pressures during lifting, and they accumulate joint / spine injuries from lifting at their limit. For health, emphasize lifting to failure with high reps (15-20) and modest weight. Lift 1-2 days a week to build up a tolerance.

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#181

Sounds plausible but can you elaborate please and is there any data/studies you know of?

#182

IMO: I think I can safely say that the short lifespan of “bodybuilders” is attributable to the use of “Roids”. "Clean resistance and aerobic training do not have this problem.

Surprisingly, just going to the gym increases lifespan less than some common sports.

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“People who play this sport live longest | MDLinx”

Thank goodness I played tennis for twenty years, maybe an extended lifespan will compensate for my effed-up ankle.

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#183

It’s been discussed in some places here in the forum/fora, so might be valuable to do a search here on rap news.

I just did a quick google search and found below paper that is recent and in a top journal, it’s likely that if you look at its references that it cites a lot of the other key papers. (I just looked quickly and included some below)

Calico (the $3 billion longevity biotech backed by Alphabet and in partnership with Abbie) have looked at it quite a bit I think and have published on it.

You can probably also find key data if you look at podcasts etc with Professor Valter Longo or get his book/audiobook.

Dietary protein restriction is increasingly recognized as a unique approach to improve metabolic health, and there is increasing interest in the mechanisms underlying this beneficial effect.

Here we demonstrate that protein restriction increases lifespan, reduces frailty, lowers body weight and adiposity, improves physical performance, improves glucose tolerance, and alters various metabolic markers within the serum, liver, and adipose tissue of wildtype male mice.

Epidemiological data suggest that lowering dietary protein content supports metabolic improvements and resilience3,4,5,6,7, while high protein intake correlates with increased mortality8,9. Protein restriction (PR) is a form of dietary restriction in the absence of energy restriction that extends lifespan and improves general health measures in various organisms, including rodents, fruit flies, and yeast10,11,12,13,14,15. The restriction of protein but not the restriction of fat or carbohydrate increases lifespan in fruit flies16,17. In rodents, PR also extends lifespan18,19,20,21, with evidence suggesting that lowering protein consumption exerts favorable outcomes on health that are independent of energy intake18. As an alternative to total PR, the restriction of select amino acids22, including methionine restriction23,24, threonine and/or tryptophan restriction25,26,27, and branched-chain amino acid (BCAA) restriction28,29,30,31, also extend lifespan in various organisms.

https://www.nature.com/articles/s41467-022-29499-8

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