Why I am very skeptical of mouse studies and medical studies in general. We should be very skeptical about our own supplement stacks.
In hopes of extending our lives and healthspan, we tend to look at favorable studies through rose-colored glasses. I am occasionally guilty of this myself. When we look at studies featuring supplements, we must be very very skeptical. There are just too many commercial and other special interests involved.
Boosting NAD+ levels for instance might have some consequences we don’t know about especially because of the special commercial and scientific interests involved.
“Cancer Research Points to Key Unknowns about Popular “Antiaging” Supplements” (1)
A good read into why studies show positive results in mice and even in some primates don’t work or are even toxic to humans and why I am very skeptical about medical studies and mouse studies in particular:
“However, the average rate of successful translation from animal models to clinical cancer trials is less than 8%. Animal models are limited in their ability to mimic the extremely complex process of human carcinogenesis, physiology and progression. Therefore the safety and efficacy identified in animal studies is generally not translated to human trials.”
“It showed that of the most-cited animal studies in prestigious scientific journals, such as Nature and Cell, only 37% were replicated in subsequent human randomised trials and 18% were contradicted in human trials. It is safe to assume that less-cited animal studies in lesser journals would have an even lower strike rate.”
"The trials were all published in prestigious neurosurgery journals and had multiple co-authors. None of the co-authors had contributed patients to the trials, and some didn’t know that they were co-authors until after the trials were published. When Roberts contacted one of the journals the editor responded that “I wouldn’t trust the data.” Why, Roberts wondered, did he publish the trial? None of the trials have been retracted."
“at least one-quarter of clinical trials might be problematic or even entirely made up”
(1) Cancer Research Points to Key Unknowns about Popular "Antiaging" Supplements - Scientific American
Of mice and men: why animal trial results don’t always translate to humans.
Lost in translation: animal models and clinical trials in cancer treatment - PMC
Time to assume that health research is fraudulent until proven otherwise? - The BMJ.
Audio long read: Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed?.
