#466

While she’s obviously right to put the patient on better medications, her strong anti supplement bias and emotionally charged tweets rub me the wrong way sometimes if I’m being honest.

3 Likes
#467

Want to bring glucosamine back into the conversation here. This is a strange 2022 result in China showing the complete opposite of the 2020 study

Here is the famous 2020 study I am talking about. The positive one
Glucosamine Use, Inflammation, and Genetic Susceptibility, and Incidence of Type 2 Diabetes: A Prospective Study in UK Biobank | Diabetes Care | American Diabetes Association (diabetesjournals.org)

#468

Another update. I’ve been traveling a lot lately and unable to ride my bike. After no cardio for 1 week I did a zwift ride where I felt like I was 5 years younger. It was amazing. I felt strong like I used to (pre-statin), I wasn’t tired afterwards, my joints didn’t hurt afterwards. It has to be the statin, of which I taking about ⅓ the past dose (now 5mg 2-3X/week) plus I’m taking GG and Urolithin A. My mitochondria have been resuscitated. I’ll be quitting the statin all together once my Bempedoic acid arrives. I’ll be 10 years younger!

8 Likes
#469

I don’t know if anyone can definitively say what OP said, but where a lot of people get the line of thinking from, and why its a common concern. Dispostion/clarity/frailty

#470

Given that you think through cycling and breaks, etc, may I ask what your UA protocol is?

1 Like
#471

@Neo I take Pure Encapsulations RENUAL in the AM with breakfast, which contains

Amount Per Serving:

Mitopure™ Urolithin A … 250 mg

Trans-Resveratrol … 150 mg
(from Japanese knotweed (Polygonum cuspidatum) extract (root))

Coenzyme Q10 … 60 mg

3 Likes
Urolithin A (UA) One of 4 Promising Agents 2024 by Brian Kennedy of NSU
#472

FWIW, I could never tolerate statins (1/4 pill 3x a week was even too much)… I have been on repatha for a few years and don’t notice a thing.

PS: had I known how much plaque I had at the time, I would have just muscled through with the statins until repatha was introduced, but here we are…

4 Likes
#473

Doesn’t Repatha has serious side effects like high BP, high Glucose and pancreatitis?

1 Like
#474

I don’t think it has had too much effect on me, personally.

My blood work results are still good, but my cgm shows I get crazy high spikes. I have been on it for years and didn’t have a cgm prior, so I can’t be sure it is caused by the repatha. My blood pressure is still good and i don’t know anything about pancreatitis.

Fwiw!

1 Like
#475

Any source for that - I thought it generally was a very safe drug (at least a decade out of use).

On the specific here is the synthesis I see:

Repatha isn’t known to cause weight loss, hair loss, or pancreatitis(inflammation of the pancreas). These weren’t reported as side effects in studies of the drug.

Repatha Injection: Side Effects, Cost, Dosage, and More - Healthline

#476

This happened to a close relative of mine (afib) on 1.5g fish oil per day. Dropped to 0.5g and problem went away.

6 Likes
#477

Repatha and pancreatitis. Don’t know how reliable this info is.

1 Like
#478

Thx will take a longer look later, just a quick reflection on the first Figure they show: 12 cases for the entire year of 2022 and 7 for all of 2023 for a block bluster size drug sounds like virtually nothing / just noise / not different than what might be in the general population

1 Like
#479

I try to keep supplementation and medications to a minimum and only those that are supported by placebo controlled studies. Anyhow, here is my list.

Supplements:

  • Multivitamin, used during calorie restriction for insurance. I try to find a low dose, such as a kids vitamin, or use every other day if dosages are higher.
  • D3, my levels have tested low before and I am going to retest soon.
  • B12, on days when my intake is minimal. Going to test levels soon.
  • Magnesium Glycinate, used on days I do not consume enough. Take 100-200mg before bed. Testing levels soon.
  • Fish oil, I take about a gram per day, but eat fish frequently. I am very happy with Viva Naturals Triple Strength. Zero fish taste ever, tested by IFOS, reasonable price, and favorable EPA/DHA ratio. Testing Omega levels soon.

Medications:

  • Ezetimibe, used to keep my LDL under 70. Have zero noticeable side effects.
  • Tadalafil, used for BPH prevention, slight blood pressure improvement, and possible anti-aging benefit.
  • Sirolimus, anti-aging and health benefits.

Supplements I am considering:

  • GlyNac, to increase Glutathione production, but I would like to see more placebo controlled studies.
  • Taurine, has been shown to extend life and other benefits, but more studies are needed.
  • TUDCA/UDCA, for liver health and gallstone prevention during weight loss.
7 Likes
#480

reasonable supplement stack and approach. Test and see if deficient, supplement deficiencies and retest. With respect of expanding supplement stack, in my mind less is more unless necessary.

4 Likes
#481

Thank you, and I agree with you that a conservative approach is best.

#482

so is novos core still worth taking? To recap its a mix of

Fisetin
glycine
pterostilbene
rhodiola rosea
micro dosed lithium
calcium alpha-ketoglutarate
malate
glucosamine sulfate
magnesium
hyaluronic acid
l-theanine
vitamin c

I’ve heard recently about the possible futility of fisetin, pterostilbene (is it close to resveratrol?), akg? Can the other items just be purchased separate?

2 Likes
#483

I purchase most of those separately.

#484

Dose matters.

When I see a high compound count in a dietary supplement formula I always ask myself, am I getting a clinically effective dose of each compound? Generally the kitchen sink formulas are low in dosing overall.

I think it’s important to understand effective dosing, otherwise there is the opportunity to waste time and money. I’m OK with the money thing but I don’t have time to waste.

4 Likes
#485

Elaborate please… As an example, what would you consider clinically effective dose for Vit C or D or any other supplement you may have info.