Tim
#210
I was in pretty good shape–almost as good as you–until I got sick when I hit 70, and that was without rappa or TRT. I deteriorated for a while but then bounced back at 75. What’s your time in the hundred-yard dash?
2 Likes
Tim
#211
@SNK, my concerns are twofold: 1) I didn’t start taking rapa until I was 74–not an ideal time to start, as most of the age-related damage has been done. 2) I have kidney disease, which automatically lowers my life expectancy. Whether rapa can mitigate the effects of the disease is unkown, but isn’t likely.
@DeStrider, I think diabetes lowers the life expectancy by an average of 12 years, depending on the age it developed and other factors like weight and blood pressure.
@DeStrider, sorry i didn’t answer your question sooner. I take spermidine, fisetin, pycnogenal, beta-alinine, and 1500 grams of baking soda diluted in water.
This last may be the best of all because it saved my life. I have acid reflux and acidosis, which are strongly associated with mortality. My nephs don’t endorse the use of baking soda to treat kidney problems, so I did my own research and found the perfect dose, which lowered all the bad numbers and raised the good ones.
Of the other supplements, the only one I’m sure of is beta-alinine. It has been well studied as a performance enhancer, with an average increase of seven percent in strength, speed, or whatever you are measuring.
@Agetron, you might look into beta-alinine yourself. I think you’d get something out of it.
4 Likes
@Tim Yes, diabetes is terrible. My concern is with the mouse study with diabetic mice. The Rapamycin-diabetic group had a lower life expectancy than the control group that was diabetic and did not take Rapamycin. They also died of diabetic inflammation instead of cancer.
Based on this study, it appears diabetics (with abnormally high blood sugar) should not take Rapamycin as it may decrease their life expectancy instead of increasing it. Other evidence is that Rapamycin+(Metformin or Acarbose) increases life expectancy beyond just Rapamycin itself.
6 Likes
Tim
#213
Hi DeStrider, do you know how well the rapa-arcarbose combination worked. Are we talking months or years?
2 Likes
If you’re talking mice, you’re always talking months. The difference with acarbose was significant and provided the maximum benefit of all ITP interventions.
2 Likes
Agetron
#215
Thanks Tim…I will definitely have a look.
@Agetron, you might look into beta-alinine.
Arhu
#216
it’s beta-alAnine, take frequent small doses throughout the day as the prickly sensation from larger doses is unpleasant
2 Likes
Tim
#217
@Arhu The prickly sensation goes away after a year or so. I take 3/4 of a spoonful. Thanks for the corrected spelling.
1 Like
Tim
#218
@Neo, what about athletes? Isn’t protein high-octane fuel for muscles?
Tim
#220
@RapAdmin, another one I’ll read tomorrow. Thanks.
Arhu
#221
Humans are not mice and in humans it is pretty well established that increasing protein intake upto 2 mg/kg increases muscle synthesis and reduces OSTEOsarcponia (yes it reduces increases bone density)
2 Likes
AnUser
#222
If you think humans are not mice and those studies aren’t very useful, why are you using a mechanistic study on fibre-deficient diet to promote carnivore diet?
Neo
#223
Yes I’d agree with that. Depends on your goals -
are your optimizing for longevity in the long run (then don’t want too many growth factors (mTOR, IGF-1, etc constantly revved up), and inflammatory process and wear, etc)
or
are you optimizing for max athletic performance (of a given sort eg the amount (and type) of muscle would be very different if goal is marathon, vs 100m sprint, vs weight lifting records).
Clearly there are overlap where a certain amount of exercise, protein and muscle training is helpful for longevity in the real world for humans (in a non sterile lab). But the optional amount of protein is almost certainty different for max muscle vs max longevity.
3 Likes
Neo
#224
One recent example by the Lamming Lab - one of the top scientists in the power of rapamycin, longevity expert, etc and followed and respected by many on these fora:
Here is the paper in a top journal:
Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice: Cell Metabolism
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00374-1
6 Likes
Arhu
#225
I would never take health advice from someone that looks like this. This isn’t a cheap ad hominem either but clearly whatever they are doing isn’t working
1 Like
AnUser
#226
That’s why I only listen to people who have heart attacks at 50 years old when looking like this.
9 Likes
Arhu
#227
Arterial plaque takes decades to form, not a few years.
But of course you can fake looking healthy with PEDs, so not everyone looking healthy is healthy but nearly everyone that looks unhealthy usually really is
3 Likes
AnUser
#228
If you really push your LDL or apoB to the limit, it will happen faster, as sometimes happens on the carnivore diet if the fatty acid composition isn’t towards more unsaturated fats.
2 Likes
DrT
#229
What do I still take apart from Sirolimus?
Metformin
Taurine
Klotho
GDF11
Astaxanthin
Captopril (Just swapped it for Enalapril)
Vitamin D + K2
Glucosamine + Chondroitin
5 Likes
