#21

How are you getting insurance to pay for this? Is your doctor using a specific cpt code?

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#22

It is worth it to put the Rapamycin tablets in a 00 capsule to prevent it from dissolving while taking it with a glass of water then. Could someone test their serum level difference of taking rapamycin tables with 00 capsules and without?

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#23

Just sent you a PM.
From others with a prescription- ordered my first script… will pay cash for the first 30 pills (Walmart has the best deal with Good RX).

It’s about $4.30 per per 2 mg.

Taken with GFJ - 2 mg… would make 6 mg weekly… cost $22 per month.

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#24

Yes, i have put sirolimus tablet in enteric capsule… not sure if it could hurt? Worst case take longer to dissolve? Any thoughts?

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#25

As long as the sirolimus tablet is itself enteric coated, it will all work well.
My thoughts were about preventing water/saliva from dissolving the tablet, it will work without enteric capsules. Remember enteric capsules probably don’t really work.

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#26

Best thing to do would be to test your blood sirolumus levels with and without this approach. How to get a Rapamycin (sirolimus) Blood Level Test

I imagine you could be protecting the sirolimus tablet so well that you just poop the tablet out a few hours later…

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#27

Chiming in here with my 2 cents:
We have done blood levels on Ramapune vs one of the generic (Dr Reddy i believe) and the results were nearly identical.
Other generic brand may or may not provide the same levels
I do NOT recommend testing 2-3hrs after. Sirolimus levels peak within a couple hours, but its very hard to catch the actual peak - so trying to do so is a fool’s errand.
Instead, I would recommend either a 24 or 48hour post-ingestion level.
Data seems to be converging on a target level of around 5 ng/ml (2 to 10ng/ml) as the “longevity” level for sirolumus.

Compounded rapamycin can be a very cost effective way of getting it. However, you will need to 3x the dose (ie instead of 5mg/wk of generic/brand, do 15mg/wk of compounded). Follow it up with a 24 or 48hr blood level.

We are writing up a paper on some of this - hope to have it submitted for publication soon…

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#28

Mark Cuban Cost Plus pharmacy has enteric coated Sirolimus tablets.

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#29

Do you know the manufacturer they use? Or can you just tell by looking at the tablet?

#30

Do you know the manufacturer they use? Or can you just tell by looking at the tablet?

Manufacturer is Ascend Laboratories, and it is shipped from a Florida-based pharmacy that is affiliated with Cost Plus called HealthDyne.

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#31

Yes - here is the exact product:

https://www.ascendlaboratories.com/Home/ProductDetails?NDC=67877074701

They also make Everolimus generic:

https://www.ascendlaboratories.com/Home/ProductDetails?NDC=67877072131

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#32

What do you see in those details that tells you the sirolimus tablet is enteric coated? I also take Ascend and get it from Cost Plus Drugs. Thank you.

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#33

I also use the Cost Plus Drugs and get the Ascend sirolimus. How can you tell they’re enteric coated?

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#34

I don’t see any details that tells me that the Ascend sirolimus tablet is enteric coated.

Rapamycin / Sirolimus is destroyed in the gastro intestinal track if its not protected, so the medicine wouldn’t work for its primary purpose (preventing organ rejection) if it didn’t have some sort of protective covering on the tablet. So, since its approved by the FDA I’m assuming that it must have some protective covering, and because otherwise people would be rejecting their transplanted organs and dying…

If you really are still not confident in the product, you can get a blood sirolimus test after taking it so you know its getting into your blood stream, see this thread: How to get a Rapamycin (sirolimus) Blood Level Test

Or you can research more on the tablet ingredients - here is a full list:

PRODUCT DETAILS

WHAT IS NDC 67877-746?

The NDC code 67877-746 is assigned by the FDA to the product Sirolimus which is a human prescription drug product labeled by Ascend Laboratories, Llc. The product’s dosage form is tablet and is administered via oral form. The product is distributed in 4 packages with assigned NDC codes 67877-746-01 100 tablet in 1 bottle , 67877-746-05 500 tablet in 1 bottle , 67877-746-30 30 tablet in 1 bottle , 67877-746-38 100 blister pack in 1 carton / 10 tablet in 1 blister pack (67877-746-33). This page includes all the important details about this product, including active and inactive ingredients, pharmagologic classes, product uses and characteristics, UNII information and RxNorm crosswalk.

WHAT ARE THE USES FOR SIROLIMUS?

Sirolimus is used with other medications to prevent rejection of a kidney transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body’s defense system (immune system) to help your body accept the new organ as if it were your own. Sirolimus may also be used to treat a certain lung disease (lymphangioleiomyomatosis-LAM).

WHAT ARE SIROLIMUS ACTIVE INGREDIENTS?

An active ingredient is the substance responsible for the medicinal effects of a product specified by the substance’s molecular structure or if the molecular structure is not known, defined by an unambiguous definition that identifies the substance. Each active ingredient name is the preferred term of the UNII code submitted.

  • SIROLIMUS .5 mg/1 - A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

WHICH ARE SIROLIMUS UNII CODES?

The UNII codes for the active ingredients in this product are:

WHICH ARE SIROLIMUS INACTIVE INGREDIENTS UNII CODES?

The inactive ingredients are all the component of a medicinal product OTHER than the active ingredient(s). The acronym “UNII” stands for “Unique Ingredient Identifier” and is used to identify each inactive ingredient present in a product. The UNII codes for the inactive ingredients in this product are:

Source: https://ndclist.com/ndc/67877-746

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#35

Thanks! I actually suspected they were all enteric coated (except maybe for the compounded products). Your logic makes sense. I did my first blood test today, 2 hours after taking 6 mg sirolimus with a small meal + fish oil. Plan to try with 2 or 3 different brands and see if there’s a difference. I’d like to use a US-manufactured brand like NorthstarRx if they’re all the same. Once that’s done, I may go back once more and test after a smaller dose with a fresh grapefruit.

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#36

Knowing the witches brew of toxic adjuvants would tell me to avoid this like the plague. Especially sodium laureth sulfate, polyethylene glycol and the rest. There’s absolutely no reason to include all of these favorite toxins of Big Pharma. Just another method of population reduction.

#37

Hi I ra g around the specialist pharmacies they ordered it in.

#39

I’ve noticed you’ve posted a few times that “enteric capsules probably don’t work.” I’m curious why you think that. Drcaps have been tested and shown to effectively delay disintegration until reaching the small intestines. I guess if you were really worried about it, you could put a size 4 capsule into a size 3 capsule?

Powdered Rapamycin from Science.bio
#40

See this comment from the Nootropicsdepot CEO:

https://www.reddit.com/r/NootropicsDepot/comments/178y2tc/comment/k5atjiw/

#41

Drcaps were actually tested on real live humans, and almost all subjects had full release in the small intestines.

I just bought some less expensive acid resistant capsules, similar to what was mentioned in the article you linked, that passed the usp test; maybe I should return them and get the drcaps. But it s
seems that if I dose in the morning on an empty stomach, and then drink water, it may be ok; i could get tested to be sure. Since 1g of powder is >160 6mg doses, it wouldn’t hurt. And from what I recall from the drcaps study; the dose was released in the small intestines completely, in most subjects tested; they ate a piece of toast with jam,and had a glass of apple juice a half hour before dosing.
DRcaps®-Capsules-Achieve-Delayed-Release-Properties-for-Nutritional-Ingredients-in-Human-Clinical-Study.pdf (1.7 MB)

And, I bought size 1 acid resistant caps, and size 4 gel caps for the rapamycin, to then put inside the acid resistant caps.

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