#146

Did pantethine lower lp(a) too?

#147

Yes, a superb article.
Table 1 on page 2 shows that the lowest dose of each statin yields about 75 % of the LDL reduction of the four times higher dose.
Statins are not side-effect free, and to me it seems prudent to go for less than the highest dose. Am on 4 mg pitavastatin, will probably reduce to 2 mg which according to the table gives a 41 % reduction in LDL compared to 48 % for 4 mg (trials on CRP show major reductions from 2 mg pita). Will start ezitimibe which should more than compensate.

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#148

So, sounds like there is no reason to take legal RYR in the US.

#149

Severity and quantity of side effects varies by person. Most people can take a statin without any side effects.

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#150

I haven’t tested that since I started Pantethine. It was very low before because I believe I have inherited genetics that naturally predisposes me to have a low lp(a).

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"Your genes control how much lipoprotein (a) you make. "
“Lipoprotein (a) Blood Test: MedlinePlus Medical Test”

#151

From another thread,{posted February 27, 2023], just to add to conversation/debate.

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#152

@desertshores Do you know if the pantethine has similar side effects to statins? Have you noticed any change in hgb A1C?

#153

No change in A1c.
I don’t think it has the same side effects as a statin. But, I didn’t have any side effects from a statin. Pantethine is related to but not the same as vitamin B5.

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#154
#155

So maybe if you take pantethine with a statin, you d need to take CoQ10.

#156
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#157

Is CoQ10 Worth The Hype? (the research no one shows) - YouTube

Coq10 supplementation does not appear to help in case you do get muscle aches from statins.

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#158

Agreed. It didn’t help me.

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#159

Peter Attia recommended Jarrow’s ubiquinol as more bioavailable.

I failed in my quest to get a low-dose statin. Yes, but let’s wait 2 months to see how ezetimibe does. Same answer for Acarbose. Yes, but one at a time. I did get an order for a CAC scan. If it is zero, I would still want to aggressively treat ApoB. But if it is terrible I would push harder.

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#160

You know you can get acarbose from India for half the cost of it here and you don’t need a prescription.

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#161

Yes, thanks! My preference is to do it here with prescription, but I will definitely buy from India if I have problems.

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#162
#163

Yes, that is definitely a downside of statins. But something that can be managed. We are lucky that we now have PCSK-9 inhibitors. That is my ace in the hole. But it would not be covered by insurance. I would love to see another 60% price reduction but I doubt that will happen.

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#164

You can always consider the Indian Pharmacy option… PCSK-9 inhibitors seem to be around $200/month currently: (82 rupees to the US dollar).

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#165

Oh, I will definitely do that!