#101

We have air purifiers in the living areas and bedrooms, also a humidifier that makes a noise . We live on a golf course but near a hospital so ambulances and fire engines regularly pass nearby so we replaced all our windows and patio doors with double glazing and that has produced a sound barrier to traffic

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#102

Oh great! That would be too insufferable for me. Although I could not tolerate healthcare work in the hospital long-term, I respect anyone who chooses to deal with the NON-patient parts like 24/7 fluorescent lighting, constant whirring of machines and ambulances.

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#103

Are the air purifiers noisy?

#104

They make a very subtle noise but we have music on for 20 minutes before we fall asleep and we cannot hear the air purifier, we have another one in the hall which is totally silent( a different model! , we have 3 altogether, when I use a hairdryer the one in the bedroom makes a loud noise.
The humidifier makes a noise , a burring sound and beeps 5 times once it’s full , but it is not near the bedroom

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#105

We have a Coway AP-1512HH, the top reviewed home air purifier by Wirecutter, that is usually silent, but the fan kicks in noisily if there is some kind of pollutant in the air at higher levels, and it can get pretty loud. But there is a setting where you can prevent the fan from kicking in. The only reason for the fan to rev up noisily is to clear the air faster, so it’s not a big deal to keep it at the minimal fan speed, which you really can’t hear unless you put your ear very close to it. We’ve had it for years, quite satisfied with it.

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#106

What happens if your nose gets stuffed up while you’re sleeping? I imagine waking in a total panic and fighting to get the tape off your face so you can breathe. But I have allergies so maybe a stuffy nose is not an issue for you?

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#107

The best way to avoid this problem is to only use a little tape between the upper and lower lips under the nose. Leave the edges of the mouth untaped so you can breathe in without effort or panic. The tape only serves to help the mouth stay closed instead of falling open.

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#108

I’ve been using ear plugs and an eye mask for over a decade and they are like my adult version of a teddy bear and help me drift off to sleep.
As for my top 5 I’d choose:
Rapa
Selegiline
Melatonin
Creatine
Rucking in nature (combining exercise with “forest bathing”)
I have a few other things I do but if I had to choose and could only keep 5 the above would be it.

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#109

That rarely happens. If my nose is going to get stuffed up, it happens before I go to sleep.
Your nose isn’t just going to completely close up and you are usually are not doing any rapid or deep breathing while asleep, so you do not need to be fully unblocked.
If you can breathe just through your nose before you go to sleep, surely you will be able to breath through your nose after you go to sleep.
I did have that happen to me once, not blocked but a little bit labored and it just woke me up enough to take the tape off of my mouth.

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#110

@blsm do you still perceive positive benefits from selegiline? I tried to check previous posts but l might have missed it.

#111

The only thing I can pinpoint to selegiline is increased motivation. I noticed this because I forgot to take it with me on vacation so a week without it made that apparent. Sadly the increased libido from it was short term and didn’t last.

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#112

Great information as always. Thank you.

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#113

Re Acarbose perhaps increasing risks of dementia:

Two Qs:

Do you know if the controls that were not taking antidisbetics had comparable degree metabolic issues, or could it be that they were not treated because they had less severe diabetes?

Are there any mechanistic hypotheses in those (or other papers you’ve seen) for why acarbose class of meds might be bad for dementia?

(I tried to access the actual papers, but they were paywalled)

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#114

And I know of no other easy way to boost mTORC2 (other than fasting)

@RapAdmin

Plus also 17 a estradiol

Or do you think that is not the case or too weak effect?

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#115

What brand of Sauerkraut to you recommend?

#116

I don’t know either (no access). As I wrote in the other thread, my guess is that acarbose use reflects some weird glycemic control (big peaks after meals?) that might be associated with more AD rather than acarbose causing AD. But who knows…

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#117

@adssx @Neo

You can ping me if you don’t have access to a paper and I can try my old login.

reddit.com/r/scholar can request papers here otherwise.

tran2024.pdf (8.9 MB)

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#118

I’ve taped for 10 years. I’ve had a stuffy nose since birth (now 69). Not an issue for me. In fact congestion has gotten much better as I’ve worked on CO2 tolerance.

In my experience, nose breathing is a “use it or lose it” proposition.

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#119

Not including diet or exercise.

  1. Dairy fat for C15
  2. Tocotrienols with Geranylgeraniol
  3. Silymarin
  4. Psyllium and inulin
  5. Melatonin
    Drugs:
    Atorvastatin
    Perindopril
    Aspirin
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#120

There is some conflicting research data on inulin (and to some other fibers):

To clarify, I think it’s good to eat plenty of fiber, but it’s probably safest to prefer foods with a lot of fiber.

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