1 Life style (Exercise no 1/CR 20:4 /sleep/meditation/social connections)
2 Photobiomodulation/near infrared for brain + QEEG / neurofeedback training
3 Glycation control Mulberry leaf extract (alternative to Acarbose, may combine)
4 Peptides Thymalin and Epithalamin/Epithalon
5 Mitochondrial control still researching

Plan to resume Rapa when lymphocytes have recovered fully.

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  1. Use your organism consciously/wisely to be balanced in everyday activities so that it is working optimally all the time.

  2. Keep your spine young and flexible (by staying thin, strong especially in the middle, and of course exercising intelligently to gain and maintain that flexibility - I choose rigourous Pilates https://www.youtube.com/watch?v=r2UUl04-lvw)

  3. Rapamaycin.

4 Other drugs like metformin and tadalafil.

  1. Have a passion, preferably one that develops you.
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That’s a sick setup! what is that called and are there compact variations of that? I’ve always loved using a back hyperextension to do similar movements, reverse hypers, glute-ham raises, etc. but never found a simple solution to let me do all kinds of variation like yours. On occasion wanted to delve more into Pilates but never got around to it.

Edit: ah a Pilates ladder barrel…

My understanding is that the mechanism of acarbose, as far as known, is to slow the digestion of certain carbohydrates. Roughly it turns simpler carbs into more complex ones, and complex ones to fiber. Naively there’s not much reason to assume that you can’t do this with just eating complex carbs and fiber to begin with. Of course inulin supplementation did fail in the ITP. The situation is more complicated. But my concerns are:

  1. Digestion and nutrition are highly variable among species. So there’s a built-in translation problem for a drug that exclusively targets digestion.
  2. The ITP mice are purposely fed a sub-optimal diet, so one might suspect some of the observed effect is compensation for that.
  3. In the unlikely event that, say, the mTORC2 effect you cite is due to something other than the known target of acarbose, we don’t know what causes it so can’t say if it might translate.

Not to claim that acarbose won’t work for humans. Just that IMO the evidence is not at as high a level.

The broader point is that few people seem to understand the sheer depth of negative results in this field. Folks on the forum are throwing out huge lists of things, based on limited evidence. I have no special insight, but if history is any guide essentially all of them will have null effect on max lifespan.

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Thanks for posting! I’d like to look more into the details of this data…

See also this one: Predicting Alzheimers (and minimizing risk) - #190 by adssx

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Correct, the ladder barrel. :wink: and you have the spine corrector and also small barrel - but of course ladder is where its happening. Of course, the Reformer offers some nice challenges, too.

Can Recommend that you fall in love with Pilates!!

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Some further reading (of abstracts…) seems to indicate low or no effect on reducing dementia, but no increase in risk. Not concerned if that’s the case.

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Could you please provide the sources? Those I remember find with no effects had large CI so impossible to conclude. The two large studies of good quality found a detrimental effect. That was enough for me to eliminate acarbose. Even more so when SGLT2i exist.

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just need to find a way to fit that machine in my dwelling!

Will have to follow up when more time, but reading the paper you linked it was comparing Acarbose to SGLT2i, not non-use.

This paper for example found reduced dementia* risk comparing non-use with ever-use of Acarbose. And lowest risk with combination of drugs they studied.

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It was comparing to non use I think.

Single author paper from Taiwan analyzing 15k people. Non statistically significant risk reduction. Only in women. It’s also non sensical from a statistical point of view that acarbose prevents dementia in non metformin users AND in metformin users who also use pioglitazone but not in metformin users only. A garbage paper to me.

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You’re right, there does seem to be a column for no-antidiabetics* in some of the tables

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  1. Exercise (Weights, high intensity cardio 5x/week)
  2. Mediterranean diet with lots of fiber and vegetables
  3. Rapamycin
  4. Acarbose
  5. Rosuvastatin
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Phenomenal response.

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  • Proper BMI, consume calories from proper foods: vegetables, fruits, nuts…
  • Psychological engagement, social contact, hobbies, passions, lust for life etc.
  • Regular exercise, 150 minutes per week of moderate-intensity aerobic activity or 75 minutes per week of vigorous aerobic activity
  • 8hrs of uninterrupted sleep every day
  • Glucose management, A1C
  • Statin, MK-4, MK-7
  • Glycine (ITP recommended)
  • NO Alcohol, NO smoking
  • Cancer screening
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6 of your 9 don’t involve medication. This should be everyone’s goal.

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Perhaps. Alternative view: nonsense. Why? Because those “non-medication” recommendations are givens. “No smoking” - duh. I’m not bagging on the list, it’s a good list, nothing wrong. I’m disagreeing that “no medication should be the goal”. Doing the obvious is obvious. What comes after is what’s at stake: the non-obvious, the hard to discern, perhaps even the controversial. It’s why we’re here. It’s the “extra”. Nobody is going to rush to a Longevity Strategies lecture that involves recommendations to breathe and also eat.

Any hope for meaningful extension of healthspan and lifespan by definition goes beyond the default non-intervention physiology. “Ordinary care”, without medication, maximizes the current potential of your body, so yes we assume you already do this, so that’s not what we are asking about. A look at the board clues us in: “rapamycin news”.

The “extra”, the beyond, necessarily involves medication, so it is the exact opposite of a goal of no medication. “No medication” will not get you beyond “ordinary care”. To go beyond, you have to go out on a limb, you must get supra-physiological help, i.e. medication, genetic manipulation, technological enhancement (f.ex. intraocular lens implants to replace deteriorated natural lenses etc.). That should be the goal, because, yes Virginia, there is no alternative. If you want to move faster between point A and point B, optimizing your running is only going to take you so far and so fast, to go faster and further you’ll need to get help beyond your body, a horse, a car, an airplane, a rocket, an intergalactic wormhole transporter. The cult of the “natural” is a resignation to limits and banal irrationality. There is no virtue in “I take no medications” - you may think you’re signalling that you’re healthy, but from my life extension perspective you are signalling that you have proudly given up on any extension, not just trailed behind in the race, but not even entered the race. You are going nowhere, and your “goal” doesn’t interest me.

If you want to extend health and lifespan, medication is not a goal, it is a necessity on the way to the real goal, life extension beyond the “natural” limits and what can be cooked up over the cave fire. To push forward we must climb down from the trees, emerge from the cave, abandon the cult of non-intervention, and wrestle from nature a longer lifespan than randomly befell us through blind evolution. In other news, on this rapamycin news, the search continues.

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But cave fires are unnatural, we natural humans only eat raw meat that we hunted with our bare hands!

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May I ask, what makes alpha lipoic acid make it ahead of acetyl-l- carnitine for mitochondrial health? What I could find in clinical indications is the reverse order, with CoQ10 being no 1. Maybe I am missing something? Saw something on advice against carnitine if you don’t have a deficiency in it…

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