Denet
#41
try different kinds of creatine. be sure to get the micronized ones. I think there’s some buffered ones too. experiment taking it with a touch of baking soda.
3 Likes
nikney
#43
1-calorie restriction, ideal height weight index, healthy diet and sleep
2-rapamycin, nad enhancers: NMN or NR
3-oxidative stress and mitochondrial control: astaxanthin, pqq, Q10, alpha lipoic acid
4-cytoprotective: ergothioneine, taurine, creatine, fisetin, quercetin
5-glycation control: acarbose, metformin
3 Likes
Those have so thoroughly failed that no one should take more than 100mg of niacin(amide) a day anymore.
3 Likes
KarlT
#46
KarlT
2d
Top five
- Exercise
- Rapamycin
- Good diet with adequate protein
- Cancer screening
- Creatine
Others:
Magnesium
Multivitamin
Fish oil
Taurine
Vitamin D
Sun Exposure
GLP1
Akkermansia
Fiber
Collagen
Statin
Ask me again next week and the list will be different. lol.
10 Likes
Lost
#47
- Rapamycin
That’s it. Nothing else has close to the same degree of evidence for extending maximum life span. I have guesses as to other things, but they aren’t in the same league.
Otherwise, standard medicine has the best available practices for avoiding premature death, but refuses to believe that aging is a distinct and modifiable entity.
5 Likes
I’d argue acarbose comes close for males
4 Likes
LukeMV
#49
Sulforaphane has a lot of potential. I wish there were more human studies.
4 Likes
Lost
#50
I agree acarbose is well supported for male mice. Can you sketch the argument that this would translate to humans? My view has mostly been that whatever benefits acarbose has can be achieved by lifestyle modifications, but the overall point that aggressive glucose control might extend maximum lifespan is a good one.
1 Like
Bicep
#51
It’s supposed to boost MTORc2. That might do it alone. Also it might not be reducing the glycemic load that improves health as much as that the sugars go to the bacteria in the colon that make SCFA. This is fundamentally good.
4 Likes
Bicep
#53
I didn’t know we could add more:
Pectasol every morning on an empty stomach and don’t eat for an hour.
Melatonin every night before bed. I use 24mg.
Yellow oyster mushroom powder for the ergothioneine, but there are more good things in there. You can’t overdo mushrooms.
1 Like
I think the two key arguments are fewer glucose spikes, and higher mTORC2. It would (from my experience) be really hard to keep your blood glucose between 80 and 110 or 120 mg/DL over the typical week and eating schedules and diets… but I find it very easy with acarbose (but I also use empagliflozin).
And I know of no other easy way to boost mTORC2 (other than fasting)… Acarbose, An mTORC2 Promoter We Should All Take?
While not definitive, the ITP studies do make a reasonable case that acarbose won’t be a net negative, and its cheap, with minimal side effects (with a non-wheat diet).
8 Likes
adssx
#55
With a higher dementia risk though in association studies (might not be causal, but just saying…): Predicting Alzheimers (and minimizing risk) - #189 by adssx
3 Likes
Out of curiosity, in the acarbose ITP trial, after the mice die, do they perform any kind of autopsy to determine cause of death and a general assessment of tissue status, f.ex. signs of brain neurodegeneration? I guess I mean in any ITP trial, but if yes, then the acarbose one might be interesting for results. Also while the mice are alive do they perform any behavioral observations for signs of subpar functioning. I find it hard to believe, though of course not impossible, that the mice lived longer, but were more demented. Of course, these are mice, and mice don’t get AD, so this may all be moot.
The other thing to keep in mind, is what was the profile of the human subjects on acarbose, to what degree were they metabolically deranged, because we do know that drugs may not work the same in healthy vs morbid patients (f.ex. metformin). Someone who is not diabetic, exercises etc. may not have a given side effect with acarbose.
Finally, for those who take many meds at once, there may be unpredictable interactions, so acarbose in the individual who is also on a SGLT2i, ARB for BP modulation, lipid modulating agents etc. may behave very differently than in acarbose monotherapy. We have no way of knowing without some studies, but I guess it’s good to be aware of possible dangers.
7 Likes
Ulf
#57
1 Life style (Exercise no 1/CR 20:4 /sleep/meditation/social connections)
2 Photobiomodulation/near infrared for brain + QEEG / neurofeedback training
3 Glycation control Mulberry leaf extract (alternative to Acarbose, may combine)
4 Peptides Thymalin and Epithalamin/Epithalon
5 Mitochondrial control still researching
Plan to resume Rapa when lymphocytes have recovered fully.
2 Likes
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Use your organism consciously/wisely to be balanced in everyday activities so that it is working optimally all the time.
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Keep your spine young and flexible (by staying thin, strong especially in the middle, and of course exercising intelligently to gain and maintain that flexibility - I choose rigourous Pilates https://www.youtube.com/watch?v=r2UUl04-lvw)
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Rapamaycin.
4 Other drugs like metformin and tadalafil.
- Have a passion, preferably one that develops you.
10 Likes
helenas
#59
That’s a sick setup! what is that called and are there compact variations of that? I’ve always loved using a back hyperextension to do similar movements, reverse hypers, glute-ham raises, etc. but never found a simple solution to let me do all kinds of variation like yours. On occasion wanted to delve more into Pilates but never got around to it.
Edit: ah a Pilates ladder barrel…
Lost
#60
My understanding is that the mechanism of acarbose, as far as known, is to slow the digestion of certain carbohydrates. Roughly it turns simpler carbs into more complex ones, and complex ones to fiber. Naively there’s not much reason to assume that you can’t do this with just eating complex carbs and fiber to begin with. Of course inulin supplementation did fail in the ITP. The situation is more complicated. But my concerns are:
- Digestion and nutrition are highly variable among species. So there’s a built-in translation problem for a drug that exclusively targets digestion.
- The ITP mice are purposely fed a sub-optimal diet, so one might suspect some of the observed effect is compensation for that.
- In the unlikely event that, say, the mTORC2 effect you cite is due to something other than the known target of acarbose, we don’t know what causes it so can’t say if it might translate.
Not to claim that acarbose won’t work for humans. Just that IMO the evidence is not at as high a level.
The broader point is that few people seem to understand the sheer depth of negative results in this field. Folks on the forum are throwing out huge lists of things, based on limited evidence. I have no special insight, but if history is any guide essentially all of them will have null effect on max lifespan.
3 Likes
