#109

That rarely happens. If my nose is going to get stuffed up, it happens before I go to sleep.
Your nose isn’t just going to completely close up and you are usually are not doing any rapid or deep breathing while asleep, so you do not need to be fully unblocked.
If you can breathe just through your nose before you go to sleep, surely you will be able to breath through your nose after you go to sleep.
I did have that happen to me once, not blocked but a little bit labored and it just woke me up enough to take the tape off of my mouth.

2 Likes
#110

@blsm do you still perceive positive benefits from selegiline? I tried to check previous posts but l might have missed it.

#111

The only thing I can pinpoint to selegiline is increased motivation. I noticed this because I forgot to take it with me on vacation so a week without it made that apparent. Sadly the increased libido from it was short term and didn’t last.

3 Likes
#112

Great information as always. Thank you.

1 Like
#113

Re Acarbose perhaps increasing risks of dementia:

Two Qs:

Do you know if the controls that were not taking antidisbetics had comparable degree metabolic issues, or could it be that they were not treated because they had less severe diabetes?

Are there any mechanistic hypotheses in those (or other papers you’ve seen) for why acarbose class of meds might be bad for dementia?

(I tried to access the actual papers, but they were paywalled)

1 Like
#114

And I know of no other easy way to boost mTORC2 (other than fasting)

@RapAdmin

Plus also 17 a estradiol

Or do you think that is not the case or too weak effect?

2 Likes
#115

What brand of Sauerkraut to you recommend?

#116

I don’t know either (no access). As I wrote in the other thread, my guess is that acarbose use reflects some weird glycemic control (big peaks after meals?) that might be associated with more AD rather than acarbose causing AD. But who knows…

3 Likes
#117

@adssx @Neo

You can ping me if you don’t have access to a paper and I can try my old login.

reddit.com/r/scholar can request papers here otherwise.

tran2024.pdf (8.9 MB)

2 Likes
#118

I’ve taped for 10 years. I’ve had a stuffy nose since birth (now 69). Not an issue for me. In fact congestion has gotten much better as I’ve worked on CO2 tolerance.

In my experience, nose breathing is a “use it or lose it” proposition.

7 Likes
#119

Not including diet or exercise.

  1. Dairy fat for C15
  2. Tocotrienols with Geranylgeraniol
  3. Silymarin
  4. Psyllium and inulin
  5. Melatonin
    Drugs:
    Atorvastatin
    Perindopril
    Aspirin
4 Likes
#120

There is some conflicting research data on inulin (and to some other fibers):

To clarify, I think it’s good to eat plenty of fiber, but it’s probably safest to prefer foods with a lot of fiber.

4 Likes
#121

Be nice to see if this is true in humans.

1 Like
#122

This case report was found. Doesn’t prove anything of course.

https://www.sciencedirect.com/science/article/pii/S277257232300198X

4 Likes
#123

Yikes. Thank you for that. I take a morning drink of 2g taurine, a teaspoon of cranberry powder and a teaspoon of inulin all dissolved in two cups of green tea. I’ve been doing this for about a year.

This report puts me off the inulin. Since I take in a ton of fiber anyway, inulin not worth the risk, however big or small.

There was a study coming out of Stanford showing that people have different reactions to fiber types. For example is some inulin caused inflammation, while in others it was beneficial.

The point being, you don’t know how your gut will react.

With this new report, to me it’s not worth the risk, so I’m dropping inulin. YMMV.

5 Likes
#124

This is concerning as Pendulum uses inulin in its Akkermansia.

@约瑟夫_拉维尔 have you heard anything about this?

This study seems to say: Inulin may be good or bad for you.

Colorectal cancer and inulin supplementation: the good, the bad, and the unhelpful - PMC.

3 Likes
#125

@KarlT No, but I can’t imagine pendulum has much inulin in a capsule. It’s there as food for the bugs. Let me know if I should worrry about it.

#126

Yes, cr is fine for young yo middle aged adults but for us boomers we can’t afford it w/o paying a heavy price. Not a great deal becoming more & more frail when nature is already doing it to us.

5 Likes
#127

Pendulum has 200 mg inulin per capsule. The case report mentioned earlier had a dose of 4 grams per day. I’m not worried about it for now and I did email Pendulum.

6 Likes
#128

Good question, challenge and reading! My frustration with my blind faith taking rapa (and about 1/2 of my nutricals) I feel no different. Least the benefit is stay the same which means I feel no different. This is the problem with what is the “best”. Depends on what measure? Agreed that staying the same forever (you never die) would be ideal.

Really good sleep was under mentioned.

Really effective exercise. (MED minimum effective dose) is in play. Can be less then one thinks if you include vibration plates and simple body weight movements.

What “measure” can mean long term or short term. In the short term, best protocols I wouild have to offer my recent opinion of peptides. There’s a BIG universe of peptides for every organ and most issues. I put use of peptides into a catagory of addressing near term issues. Rapa is (to me) is to keep you the same. Peptides reduce or eliminate negatives. I think they go together.

This is a good over view of the universe of peptides.

Good luck, to all, curt

3 Likes