#147

FWIW

There are 50/fifty claims in the patent application.

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#148

What is there to pull off?

It is a very simple procedure, cost very little with a potential of much larger benefits.

As I have stated this is a no brainier.

In my view this is even less risk than taking rapamycin.

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#149

I should say:

If you guys notice any improvement like that 77-year-old man.

I sincerely hope you do as it sounds like a highly innocuous yet effective therapy. I don’t see any downside here except wasted time and effort.

I would love a beneficial therapy to be this easy. It sounds too good to be true. I am eagerly waiting to hear back about this group’s progress.

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#150

Usually is my friend, but maybe we will win the lottery.

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#151

I am rooting for all of you!

Go Team Longevity! :slight_smile:

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#152

If this treatment removes cancer stem cells will it not also remove other types of stem cells? And, is that a potential problem? Outside of those possibilities I’m onboard with this.

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#153

Taking doxycycline and azithromycin for life extension makes no sense to me. One of my primary areas of focus for healthy longevity is maintaining a healthy Microbiome. And abiotic drastically disruption in Microbiome, GI inflammation, intestine, permeability, and LPS leakage. All of these contribute to chronic information, which accelerate, biological agent. No thanks to antibiotics for me… I am the Microbiome guy.

Here is a link For a FREE copy of a booklet I wrote titled Dr. Ohhira’s Probiotics & Postbiotic Metabolites: Probiotics & Postbiotic Metabolites | Ross Pelton | The Natural Pharmacist

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#154

It makes even less sense if there isn’t a lifespan study in for example mice, like how there is for rapamycin or acarbose. That’s the minimum level of evidence I consider.

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#155
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#156

I’ll curiously watch what happens to you lab rats, although I don’t think you’re going to notice much of anything. Hopefully no bad side effects. Don’t know how you will know if it “worked”.

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#157

Yes this is most likely going to have zero effect.

#158

And you base you assumption on what?

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#160

Just as us who take rapamycin do not know if rapamycin “works” in humans to extent human lifespan.

For myself, I read, review speak to a few people
and use critical thinking to make my own decisions.

:“When writing the story of your life, do not let anyone else hold the pen”

~Jack Kerouac

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#161

Entering phase III study means it probably wont work?

#162

“People who say it cannot be done should not interrupt those who are doing it.”

~ These words are often attributed to Asian sage Confucius

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#164

I feel partially responsible since I shared the study and patent application, but since than I have reviewed a lot of science behind it and as you said it is a no brainer. Even rapamycin dosage in humans seems more guessing than working with something concrete even if there is some strong data in mice studies. Since reading all this, talking to few people and reading discussions here on the subject I decided to try it. Probably not immediately since I am trying to put on some muscles in the next weeks/months and I need protein synthesis pathways open :wink: but after this I will try it. I have both doxy and azithromycin at home (don’t ask me why :flushed:), just ordered vitamin C.

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#165

I Thank you scta123 for posting the two documents.

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#166

I respect that. I personally will take the side effect profile and risk reward equation of Rapamycin over Doxycycline.

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#167

Phase I was not necessary since all drugs are already approved. Phase II was done on cancer patients and they are conducting phase III or will start soon from what I gathered. If you understand science behind it in cancer (basically in short senescent cells turn into cancer stem cells so it made sense to target CSC with senolytic drugs… they have proven this therapy it selectively targets senescent cells (or CSC in which they were interested))
Senescence is the mayor aging drive force, rapamycin affects senescence too (by preventing it trough autophagy), so it really does make a lot of rational sense to target senescent cells.

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#172

Seems, it is the senolytic effect that is being chased, not the anti-bacterial.

The present approach effectively eradicates senescent cells and cells carrying the hallmarks associated with aging, through inhibiting mitochondrial biogenesis during induced mitochondrial oxidative stress, without inhibiting normal cells.

Many here have tried fisetin with middling to no effect. Some have tried D +Q. So maybe this combination is another, in the arsenal of senolytics.

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