DrT
#57
The article states that the modified Doxy is 5 times as potent as the unmodified one. So it could be that the original work used 100mg of Doxy, while the newer research used 20mg of Doxy-myristol?
1 Like
JuanDaw
#58
Seems to be a reasonable inference.
blsm
#59
@Rmun, I’m considering joining you in trying this with a lower dose of doxycycline as well this time around. I’m 53 y/o and 5’1/100 pounds. I don’t know if size matters with this particular med. I have noticed in the past when I’ve actually been on doxycycline for an infection and taken it later in the day it disrupted my sleep. I’ve probably got about 10 days before my order arrives to decide.
3 Likes
I’m also thinking of jumping on this bandwagon!
I’ve been interested in Doxycycline for some time, after taking a relatively potent course (100mg 2x/day 2-3 weeks, for an infection) which incidentally ~90% cleared up a long-standing, sometimes debilitating and worsening chemical allergy (perfumes especially) - that was a surprising and very welcome side-effect. That allergy has started to creep back this past year and I’ve been thinking about a reasonable protocol to restart this. This “DAV Therapy” might be a neat way to cover both interests in one.
6 Likes
KFISH
#61
Yes- I am pausing Rapa. I will let you know what if any blood markers improve along with wellbeing.
1 Like
约瑟夫
#64
Review these two videos!
Professor Michael P Lisanti is brilliant.
I will post my comment again.
This is a no brainier.
5 Likes
JuanDaw
#65
https://www.medkoo.com/products/40838
Description: Doxy-Myr is a Myristoyl Amide Derivative of Doxycycline, which potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis. Doxy-Myr is >5-fold more potent than Doxycycline, as it appears to be better retained in cells, within a peri-nuclear membranous compartment. Moreover, Doxy-Myr did not affect the viability of the total MCF7 cancer cell population or normal fibroblasts grown as 2D-monolayers, showing remarkable selectivity for CSCs. Doxy-Myr can effectively minimize the risk of driving antibiotic resistance.
This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Area code of phone number indicates they are in Raleigh, North Carolina.
3 Likes
scta123
#67
Rapamycin is an antibiotic.
1 Like
scta123
#69
I know it is not a strong argument but comparing rapamycin and doxy in C. Elegans and longevity it seems that they are quite similar. I am now wondering why doxy did not get any mouse studies but probably they are on the way I would imagine since doxy is a senolytic and rapamycin is senescence preventive. Azithromycin is a senolityc too (without any studies on life extension). They probably work trough the similar pathways to prevent, delay, slow aging.
and doxycycline:
2 Likes
约瑟夫
#70
Not profitable, no IP the major reason.
Who is going to fund a possible treatment procedure with a total cost to the end used for less than $50.00?
4 Likes
Bicep
#71
It doesn’t even lower cholesterol!
1 Like
scta123
#72
But doxy might prevent ASCVD in subantimicrobial dose.
4 Likes
Acarb
#73
Minocycline, another tetracycline that extends lifespan of worms and flies, failed the ITP.
JuanDaw
#74
Graphs show it worked for males, not females.
scta123
#75
seems it is an mTOR activator. Doxycycline seems mTOR neutral and works synergistically with rapamycin.
The rapamycin + doxycycline combination had serious tumour growth inhibition in the performed in vivo experiments, as well.
3 Likes
约瑟夫
#76
In my view another no brainer for anyone diagnosed with breast cancer.
1 Like
Senolytics reduce senescent cells which reduces inflammation and heart disease IMHO. It makes sense to me.
3 Likes
KFISH
#78
I am taking a supplement butyrate a short chain fatty acid for the gut- in addition to prebiotic in fermented foods. Not yogurt bc of dairy interferes with the antibiotics.
2 Likes
