#63
2 Likes
#64

Review these two videos!

Professor Michael P Lisanti is brilliant.

I will post my comment again.

This is a no brainier.

5 Likes
#65

https://www.medkoo.com/products/40838

Description: Doxy-Myr is a Myristoyl Amide Derivative of Doxycycline, which potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis. Doxy-Myr is >5-fold more potent than Doxycycline, as it appears to be better retained in cells, within a peri-nuclear membranous compartment. Moreover, Doxy-Myr did not affect the viability of the total MCF7 cancer cell population or normal fibroblasts grown as 2D-monolayers, showing remarkable selectivity for CSCs. Doxy-Myr can effectively minimize the risk of driving antibiotic resistance.

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Area code of phone number indicates they are in Raleigh, North Carolina.

3 Likes
#67

Rapamycin is an antibiotic.

1 Like
#69

I know it is not a strong argument but comparing rapamycin and doxy in C. Elegans and longevity it seems that they are quite similar. I am now wondering why doxy did not get any mouse studies but probably they are on the way I would imagine since doxy is a senolytic and rapamycin is senescence preventive. Azithromycin is a senolityc too (without any studies on life extension). They probably work trough the similar pathways to prevent, delay, slow aging.

Screenshot 2023-09-30 at 16.56.24
Screenshot 2023-09-30 at 16.56.241198×838 80.6 KB

and doxycycline:

Screenshot 2023-09-30 at 16.56.52
Screenshot 2023-09-30 at 16.56.521000×624 46.2 KB

2 Likes
#70

Not profitable, no IP the major reason.

Who is going to fund a possible treatment procedure with a total cost to the end used for less than $50.00?

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#71

It doesn’t even lower cholesterol!

1 Like
#72

But doxy might prevent ASCVD in subantimicrobial dose.

4 Likes
#73

Minocycline, another tetracycline that extends lifespan of worms and flies, failed the ITP.

#74

Graphs show it worked for males, not females.

#75

seems it is an mTOR activator. Doxycycline seems mTOR neutral and works synergistically with rapamycin.

The rapamycin + doxycycline combination had serious tumour growth inhibition in the performed in vivo experiments, as well.

3 Likes
#76

In my view another no brainer for anyone diagnosed with breast cancer.

1 Like
#77

Senolytics reduce senescent cells which reduces inflammation and heart disease IMHO. It makes sense to me.

3 Likes
#78

I am taking a supplement butyrate a short chain fatty acid for the gut- in addition to prebiotic in fermented foods. Not yogurt bc of dairy interferes with the antibiotics.

2 Likes
#79

@KFISH, I’ve been considering making kefir water lately. Now might be a good time for me to make the plunge.

1 Like
#80

For some reason I was thinking yogurt was a good way to avoid causing problems from antibiotics. What is the interference? Thanks,

#81

That is a good question, since I was told as a kid from my aunt (MD) that I should’t take antibiotics with a glass of milk and have been avoiding milk and antibiotics ever since without even thinking about why…

2 Likes
#82

Interference seems to have to do with calcium, which is found in dairy.

Using medication: Using antibiotics correctly and avoiding resistance - InformedHealth.org - NCBI Bookshelf.

  • What food can you take antibiotics with? Antibiotics are usually taken with water because taking them together with fruit juices, dairy products or alcohol can affect how the body absorbs some drugs. Dairy products include milk as well as butter, yogurt, and cheese. After taking an antibiotic you may need to wait for up to three hours before eating or drinking any dairy products. Grapefruit juice and dietary supplements containing minerals like calcium may also work dampen the effect of antibiotics.

Complete avoidance may not be necessary. Just don’t take them within three hours of each other. So dairy at lunch (assuming dosing in the AM and before bed) should be okay.

2 Likes
#83

I have been updating the first posting on this thread .

Reposting the part about milk products

3 Likes
#84
2 Likes