Does anyone know of good studies that investigated the impact of PDE5 inhibitors on all-cause-mortality in healthy populations (no CVD risk factors)?
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No, but…
and
Phosphodiesterase Type 5 Inhibitors in Men With Erectile Dysfunction and the Risk of Alzheimer Disease
A Cohort Study
PDE5I initiation in men with ED was associated with a lower risk of AD, particularly in those most frequently issued prescriptions. The differences between primary and sensitivity analyses highlight the need to explore the optimal lag period. To enhance the generalizability of our findings, a randomized controlled trial including both sexes and exploring various PDE5I doses would be beneficial to confirm the association between PDE5I and AD.
Open Access Paper:
https://www.neurology.org/doi/10.1212/WNL.0000000000209131
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Quick linking! Popped up on my news feed also. Alzheimer’s is looking more and more like just an extension of cardiovascular disease every year. Anything that helps arterial health should help the brain.
My personal preference would be for tadalafil due to its longer half-life and more selective action (less inhibition of PDE6). There are some questions over sildenafil and eye health although recent studies appear to suggest it’s ok.
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Lost
#28
Non-selective PDE inhibition is also interesting from a longevity perspective, given that various of the enzymes other than PDE5 appear sporadically in the literature. As far as I know there isn’t yet a consensus on why one observes a correlation of caffeine intake with lifespan but it seems plausible at least some of it is directly caffeine. A better tuned xanthine drug, like pentoxyfylline, would certainly perform better. Now that the PDE5i’s are off patent and super-popular I’m not sure is there’s any financial advantage though.
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LukeMV
#29
So they only checked for people with Vagra prescriptions but not cialis?
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That’s great, thanks for sharing!
It looks like healthy and young folks are less likely to benefit based on this:
E.g., see “<70 years”.
Or would you draw a different conclusion?
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SNK
#31
Received my order of Cialis couple days ago and started taking 5mg yesterday. while I felt fine generally speaking, my red face makes me look like a lobster (for last 24 hours). Viagra never gave me this effect for some reason, but I had headaches and acid reflux from Viagra but not from Cialis. I think I will cut the pills further and only take 2.5mg as opposed to 5mg I was taking and see if my redness will disappear.
BTW, I also received Jardiance, and rosuvastatin with this order and took them both last couple days. It seems that I might be a bit weaker (did same weights last night but could only do about 10-11 reps as opposed to usually doing 13) but other than that I feel great. I must play with doses though, and I intend to take the least possible dose for each of these meds (since I have absolutely no need medically for any of them but am using them for longevity).
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LukeMV
#32
Yea I had to lower cialis to 2.5mg as well. The red eyes that drug gives me sucks.
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I’m intrigued about the longevity benefits of Cialis. However, I already have tinnitus that I’m trying to manage and worried about that side effect as well as hearing loss. Has anyone experienced this side effect of Cialis and if so, when you stopped, did the symptoms go away?
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In case this video has not been posted here (I couldn’t find it), here is a physionic video on tadalafil (which I take).
In addition to BPH benefits (and ED benefits):
- maybe increases free testosterone
- seems to increase insulin (concerning)
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SNK
#35
Dang, I wish I wasn’t allergic to it. I have reverted to sildenafil since that one I can tolerate better (gives me a slight heartburn), but the effects are much more subtle than that of the Tadalafil. I wouldn’t worry about insulin increase unless one is diabetic.
Forgot to add both Cialis and Viagra seem to negatively effect my eye sight. I almost never need glasses to read a book, but I definitely need glasses if I’m taking either of the two. As for tinnitus it seems to aggravate it a bit also (both of them) but I have lived with it for over 5 years and it is not that bothering, unless I specifically pay attention to it. BTW, the only thing that ever made a difference (for good) on my tinnitus was a very soft music into my ears.
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Just and FYI- “It should be noted that most animal work has used naloxone, while most human work has used naltrexone (because of its higher oral availability). We cannot discount the possibility that findings from one compound would imperfectly translate to the other.” The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain - PMC
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tj_long
#37
Tadalafil/sildenafil is associated with increased melanoma in a few follow-up studies. Doesn’t prove causality, of course. Has anyone looked into this in more detail?
”
Some studies have shown that Viagra may decrease activity of our natural killer cells, which are our first line of immune defense against cancer.”
This is a somewhat worrying claim. On the other hand, this pilot study says:
” Our preclinical data showed that the phosphodiesterase (PDE)-5 inhibitor sildenafil impaired MDSC functions, enhanced intratumoral T cell activity and prolonged survival of melanoma-bearing mice.”
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Alex
#38
I recall once we were taking a sea voyage on a smaller boat and the seas were rough. So one of the crew offered dramamine or some homeopathic pill. I took the dramamine. Everyone who took the homeopathic pill got sick. When they complained to this guy, he said it was their fault because they “touched” the pill before swallowing it. I guess the way that it works well is to not ever have it interact with your body!
Seriously, there is so much nonsense with this whole thing, its actually comical.
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Anyone know the dosage to get maximum benefits from Sildenafil? 50 mg? 25 mg? Daily? Weekly? Can you even split this pill?
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Alex
#40
When splitting I put them inside enteric capsules. Can buy on bulk on Amazon. Maybe not needed but seems a good precaution.
For the dose I really think its idiosyncratic but perhaps a more professional opinion would know better.
I am trying out Tadalafil and it is going well for me. But I get that its not for you.
