#1

Just read this blog post by Peter Diamandis about TPE. Wondering your thoughts on this for longevity? Anyone know where to find out who (what Doctor) does this in my area (Phoenix, AZ)?

Plasma Exchange
#2

My apologies. I should have done a search on TPE before posting this. I now see that Rap Admin has actually had TPE done and discussed this.

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#3

But I donā€™t identify any places that offer it other than the one I went to; Dobri kiprovā€™s clinic in mill valley California. Perhaps we can identify some other locations.

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#4

From the Fight Aging! Newsletter

ā€œ the use of therapeutic plasma exchange as an approach to treat aspects of aging, the practical way to implement something like parabiosis in humans. Clinicians can remove plasma and substitute in young plasma, but this can produce side-effects. So they instead use 5% albumin in saline. Albumin comes from donor plasma, where the average age of donors is 25 or so. Kiprov argued for the quality of the albumin to likely be an important factor in the effects of parabiosis, given it has immunomodulatory, anti-inflammatory, and antioxidant effects.ā€

Has a comparison of this (saline plus a bit of young albumin) to frequent blood donation been done? If the issue is iron getting too low surely that can be remedied.

Iā€™ve been donating blood every 3 months for the last 9 months now. Iā€™m trying to get my iron lower but maybe Iā€™m getting rid of old blood factors too.

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#5

I have to say this idea of TPE, transferring young blood into an older person, intrigues me, and makes sense how it works. However, I would only do this with somebody who is genetically related (blood type ā€¦etc.) and I know their health status and historyā€¦ like my son. Similar to Brian Johnsonā€™s use of his mini me son.

My son who is an RN says heā€™s down for it (great kid), if I want. Now just finding someone to do it safely at an economical price in Missouri is the challenge. :wink:

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#6

Yes. I wonder how much of the benefit is from discarding the old stuff (similar to but more volume than a blood donation?) vs obtaining young albumin (5% young albumin in saline is enough?) vs entire blood plasma contents of a young person to replace the discarded old blood plasma?

https://www.science.org/content/blog-post/young-blood-and-old-blood

ā€œThe authors tried several control experiments to make sure that this wasnā€™t an effect being driven by added albumin protein, and it apparently isnā€™t. They conclude that removal and substitution of old plasma "is sufficient for most if not all observed positive effects on muscle, brain and liver " in parabiosis-type experiments. It doesnā€™t exclude the idea of there being beneficial factors in young plasma, but suggests that this is not the driver of many of the results seen.ā€œ

Is the reason we canā€™t donate blood too frequently related only to iron or is it many blood factors that get too diluted?

Who knows about this?

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#7

Latest parabiosis paper seems to support that there is good stuff in young blood and that it might be both.

GeroScience
Article

Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged mouse brain

Published: 10 May 2024

Our results indicate that short-term exposure to young systemic factors leads to both functional and structural rejuvenation of cerebral microcirculation.

The rejuvenation observed in the endothelium, following exposure to young blood, suggests the existence of anti-geronic elements that counteract microvascular aging. Conversely, pro-geronic factors in aged blood appear to accelerate cerebromicrovascular aging. Further research is needed to assess whether the rejuvenating effects of young blood factors could extend to other age-related cerebromicrovascular pathologies, such as microvascular amyloid deposition and increased microvascular fragility.

Sinclair discussed the paper and listed ideas for what in the young blood it could be:

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The GDF11 paper he pointed to is: GDF11 reverses mood and memory declines in aging | Nature Aging

Overall short tweet commentary:

https://twitter.com/davidasinclair/status/1792338535581638658?s=46&t=zJMJ1xVdRJYEDYz-DHipTw

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#8

Related: plasma donation as a way to remove microplastics? https://www.youtube.com/watch?v=K2S7vbJZ8kY&list=PLKTKetGpQgfs_BC3k61BboA2ppDYEByro&index=1

#9

Yeah, but the blood bag often contains plastics and plasticizersā€¦

#10

Yeah, this made me just donate blood recently, instead of plasma.

More than 20 plasma donations last year made me feel that currently Iā€™ve diluted my blood sufficiently of PFAS, and microplastics (?) such that I should now be concerned about the plastic in the saline bag / tubing.

#11

Do you want to transfer blood, not just plasma? Are you the same blood type as your son? It would be easy for me (Iā€™m a universal recipient), but not sure if itā€™s safe taking into consideration of my transplanted kidney. And nobody can tell me for sure.

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#12

Thanks for the offer. Sweet!

I would only consider whole blood from my 33 year old sonā€¦ and even then itā€™s more of a what if? For the youthful benefit.

We are the same blood type O+ universal donor. And I know his health history. More of a whim.

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#13

No, I was not offering :grinning:I meant that I would consider the same procedure with my son for rejuvenation purposes, but not sure if receiving his blood would be ok for me taking into account that I have transplanted kidney. I asked my doc and he didnā€™t know if itā€™s safe. I guess not many ppl with transplants do that.

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#14

Anyone doing multi-TPEā€™s / yr as an anti aging protocol?

I called maxwellclinic.com in Nashville TN and their secret sauce called HOPE costs $8k/per and a few / yr are recoā€™ed.

tnx curt

#15

I did a series of 6 TPE treatments in 3 months and really did not see any noticeable (or measurable) benefits. I was in this clinical trial: Plasmapheresis Startup Looking for Clinical Trial Participants SF Bay Area

I think the normal price for their TPE services are around $5,000 to $6,000 per treatment: https://www.globalapheresis.com

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#16

Did you get your individual before, during and after data points from the trial? Did you have before and after PACE clock data?

The trial in aggregate did show positives, are you younger/better BMI/etc than the average participant in the trial?

How do you filter out your pre raps but not during rapa from confounding your before and after data and subjective feelings?

#17

Tnx alot for this comment! Maxwell Clinic touts their nice acronym HOPE protocol of what they add back secret sauce. I also hear that the replacement for the removed plasma of an albumin is also significant as to what the plasma is replaced with.

I have not done any more digging then just reading maxwells website. A clinics secret sauce is not divulged in plane view.

My plan is to pay Alex Kikel his $200/mo to join his inner circle, then get referrals for his preferred service providors, TPE, Cell Factor (exosome excremantsā€¦) etc. Then quit. Hes ok with joining learning quiting. (only FYI) TPC ARMY

Its worth your time searching / watching on youtube: Alex Kikel peptides. His info is dense and wide! The peptide added word separates the results from the other Kikels.

Good luck all, curt

#18

I would definitely give this a try, but I donā€™t have a spare 12K for the procedure.
It would seem plausible that it would at least extend healthspan.

From the tabloids:
ā€œSimon Cowell has claimed that he has managed to ā€˜age backwardsā€™ by using a controversial blood filtering trend.ā€

"Orlando Bloom, former Dallas Cowboys quarterback Troy Aikman and Star Trek actor Paul Wesley have all posted snaps of themselves having the procedure.

During the procedure, known as plasmapheresis or therapeutic plasma exchange (TPE), patients are hooked up to a machine that filters plasma out of their blood and replaces it with albumin, the most abundant protein in the blood.

Blood plasma can contain inflammation-causing proteins, microplastics, forever chemicals and other potentially harmful substances. The albumin replaces the plasma and does not contain these toxins."

Clarify Clinics offers a similar procedure to TPE, costing $12,700, but its method filters the patientā€™s own plasma of toxins before returning it.

TPE takes around two to three hours to complete and requires patients to sit in a chair with an IV in both arms.

During the procedure, the machine removes about 75 percent of plasma, about two out of the 2.7liters of plasma an adult is estimated to have. Overall, adults have between 4.7 and 5.7liters of total blood in their bodies.

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Reported Users
While comprehensive data is sparse, tabloid and social media searches reveal the following individuals associated with the procedure:

  • Bryan Johnson: Biohacking entrepreneur who underwent total plasma exchange to remove toxins, claiming his plasma was exceptionally clean; part of his regimen to reverse biological aging.
  • Peter Diamandis: XPrize founder who has tried plasma exchange as a longevity treatment to reduce inflammatory factors.
  • Troy Aikman: Former NFL quarterback who described it as a ā€œhuman oil changeā€ for revitalizing circulation and removing age-related toxins.
  • Orlando Bloom: Actor who shared his experience on Instagram, using it to filter out microplastics and chemicals for overall health optimization.
  • Paul Wesley: Actor known for Star Trek and The Vampire Diaries, who posted about the procedure in recent months for longevity benefits.
  • Bella Hadid: Model who uses plasmapheresis as part of alternative treatment for Lyme disease, clarifying itā€™s not dialysis.
  • Johnjay Van Es: Radio host who incorporated it into biohacking after significant weight loss, spending over $100,000 annually on health protocols including TPE.
The fight against time: can we slow down ageing? - with Carina Kern (LinkGevity)
#19

Maybe itā€™s not that bad that you donā€™t have a spare 12k because it could be wasting of money.

Even though itā€™s getting more popular, there is no proven increase in lifesspan, no rejuvenation of organs that lasts, no improvement in epigenetic aging clocks.
Effects on inflammation last only days to weeks. Most reported benefits are subjective and temporary.

A 75% plasma removal sounds dramatic, but aging factors quickly equilibrate, and levels return to baseline rapidly.

This is why many longevity researchers now consider TPE interesting but likely ineffective for aging itself.

People who benefit typically:

:heavy_check_mark: have autoimmune diseases

:heavy_check_mark: have high inflammation

:heavy_check_mark: have pathological antibodies

:heavy_check_mark: have neurological diseases responsive to TPE

Their benefits come from removing disease-causing proteins. If you donā€™t have those diseases it may not even benefit you or may even harm.

Consider yourself lucky that you donā€™t have a spare 12k :grinning:

.

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#20

I agree with LaraPo here, in terms of ā€œbang for the buckā€ TPE is probably very low in the ranking. And we have no idea how long the benefits last (I didnā€™t notice any benefits), and I suspect itā€™s only a few months in the best of cases.

Having a really good weekly personal trainer would probably be a much higher benefit to make sure you do really well designed and comprehensive workouts (and to keep you motivated)ā€¦ there are a thousand things higher than TPE on my listā€¦

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