#41

I don’t know who or what is behind the push against statins but people who don’t treat their apoB aggressively are doing a mistake that’ll cost them their life.

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#42

Yeah and what I meant wasn’t secondary prevention, but primary prevention, more specifically preventing atherosclerosis building up.

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#43

The fact that Brad Stanfield, MD put himself on a statin at age of 27 is pretty telling. HOWEVER twenty five years ago I have known cardiologists that were putting themselves on beta-blockers and aspirin prophylactically… and I am pretty sure no cardiologist would that now without a good indication.

Personally I don’t have FH of CAD and but I managed to keep my LDL in the 70-80 range with just lifestyle changes. I will have to check my ApoB and (a) one day.

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#44

So for someone to proclaim that their 100+ supplement stack is effective and safe because they did their “research” is a combination of hubris and foolishness. Animal studies mean nothing. Observational studies mean nothing. Show me a 1000+, multi-center, long term RCT - then we can talk.

That’s great you have such high epistemic standards, but the reality is that such evidence doesn’t exist for the vast majority of interventions being discussed on this site.

We have limited information, and we have to try to and make our best judgement of what to do with it. I hope you’re joking to say animal studies mean nothing. If that were actually the case, nobody would waste time doing them.

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#45

Wild he posted this on a site called rapamycin.news

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#46

Statins, BPA/EZET/PCSK9i, BP-lowering meds, SGLT2i… What did I miss?

image

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#47

Did you look back on the original post? It was about Vitamin E…not a pharmaceutical.
And yes rapamycin is a pharmaceutical but that’s not what was being talked about.
It’s about SUPPLEMENTS…get it?

#48

I was just asking what intervention I missed.

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#49

Vitamin E, it’s the greatest thing ever…we all know that.

#50

What kind of a complete moron would add a supplement in a 100+ stack that didn’t show at least some efficacy in an animal study ? That has be the lowest of low bars of inclusion.

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#51

The question is which supplement will become the next Vitamin E. So far Niacin is winning. NMN might be next.

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#52

Rapamycin is an FDA approved pharmaceutical, however only a complete idiot would create a 100+ stack of off label pharmaceuticals to “experiment” on, right? But supplements? They MUST be safe because they are “natural”. :rofl:

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#53

There are advantages to taking molecules with a long track record in that there are likely to be some records as to when there are adverse responses. Eg ashwagandha has a track record of exacerbating liver disease.

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#54

Most supplements are placebos. So, taking 100 placebos should give you the benefit of 30. :wink:

Although those with scientific studies may provide a better return.

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#55

You have mentioned aspirin under the “now we know better” category about its safety/usefulness. Frankly, I see it as a miracle drug, and while not dismissive of its risks, wonder just how to qualify those risks. It can impact stomach lining for example. In just some people? At really low doses? It also increases the risk of brain bleeding. Is this primarily a risk for people older?

To minimize the risk, I now use willow bark. But I would like to know how you perceive risk of low dose aspirin specifically to your practice. Because the gains of such a cheap drug to anti-cancer benefits as well as preventing prostrate growth/cancer rates seems to be “miraculous.” Good studies are provided @ Exploring Strategies for Prostate Health and Cancer Prevention - #71 by JuanDaw and elsewhere on the forum.

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#56

Hmmmm…well, at least the placebo in the bottle labeled “lithium” is working for me. But I do object to claims that any supplement that doesn’t have…

…is worthless and that we must be “morons” or “complete idiots” to take it. :roll_eyes:

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#57

I have taken aspirin for my entire life along with many millions of others without any ill effects. My colonoscopy at age 70 impressed the doctor. He said he had never seen such a clean colon in someone my age. Unfortunately, studies indicate that this only occurs with long use of aspirin. Like you, I have switched to white willow bark instead of baby aspirin because it has more benefits than pure aspirin.

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#58

If that is your criteria, don’t take rapamycin, most supplements, and many medicines.
Covid shots come to mind.
Long-term RCTs are just not practicable at this time in humans for anything claiming life extension benefits.

There are many long-term RCT studies of lithium but these are primarily for the use of lithium in clinically therapeutic doses for treating mental disorders, primarily depression and bipolar disorders.

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#59

Sorry if I was misleading. But @jnorm was criticizing that comment, just as I was. The original quote was from @Dr.Bart so I’ll let him defend it.
Edit: There, I fixed it.

#60

Well, yes…that’s why I would like to believe that what I’m taking is just a placebo…because I don’t need therapeutic doses…do I? Hello…anybody out there? Sorry, I was hearing voices…

1 Like