What kind of a complete moron would add a supplement in a 100+ stack that didn’t show at least some efficacy in an animal study ? That has be the lowest of low bars of inclusion.
1 Like
The question is which supplement will become the next Vitamin E. So far Niacin is winning. NMN might be next.
2 Likes
Rapamycin is an FDA approved pharmaceutical, however only a complete idiot would create a 100+ stack of off label pharmaceuticals to “experiment” on, right? But supplements? They MUST be safe because they are “natural”. 
3 Likes
There are advantages to taking molecules with a long track record in that there are likely to be some records as to when there are adverse responses. Eg ashwagandha has a track record of exacerbating liver disease.
3 Likes
Most supplements are placebos. So, taking 100 placebos should give you the benefit of 30. 
Although those with scientific studies may provide a better return.
3 Likes
You have mentioned aspirin under the “now we know better” category about its safety/usefulness. Frankly, I see it as a miracle drug, and while not dismissive of its risks, wonder just how to qualify those risks. It can impact stomach lining for example. In just some people? At really low doses? It also increases the risk of brain bleeding. Is this primarily a risk for people older?
To minimize the risk, I now use willow bark. But I would like to know how you perceive risk of low dose aspirin specifically to your practice. Because the gains of such a cheap drug to anti-cancer benefits as well as preventing prostrate growth/cancer rates seems to be “miraculous.” Good studies are provided @ Exploring Strategies for Prostate Health and Cancer Prevention - #71 by JuanDaw and elsewhere on the forum.
1 Like
ng0rge
#56
Hmmmm…well, at least the placebo in the bottle labeled “lithium” is working for me. But I do object to claims that any supplement that doesn’t have…
…is worthless and that we must be “morons” or “complete idiots” to take it. 
2 Likes
I have taken aspirin for my entire life along with many millions of others without any ill effects. My colonoscopy at age 70 impressed the doctor. He said he had never seen such a clean colon in someone my age. Unfortunately, studies indicate that this only occurs with long use of aspirin. Like you, I have switched to white willow bark instead of baby aspirin because it has more benefits than pure aspirin.
2 Likes
If that is your criteria, don’t take rapamycin, most supplements, and many medicines.
Covid shots come to mind.
Long-term RCTs are just not practicable at this time in humans for anything claiming life extension benefits.
There are many long-term RCT studies of lithium but these are primarily for the use of lithium in clinically therapeutic doses for treating mental disorders, primarily depression and bipolar disorders.
4 Likes
ng0rge
#59
Sorry if I was misleading. But @jnorm was criticizing that comment, just as I was. The original quote was from @Dr.Bart so I’ll let him defend it.
Edit: There, I fixed it.
ng0rge
#60
Well, yes…that’s why I would like to believe that what I’m taking is just a placebo…because I don’t need therapeutic doses…do I? Hello…anybody out there? Sorry, I was hearing voices…
1 Like
You have mentioned aspirin under the “now we know better” category about its safety/usefulness
Blockquote
Another one of those drugs that was passed around like candy, it should be used for specific indications.
2 Likes
Oh wow, another distortion, taking bits of my unrelated posts and stitching them out of context.
I thought we made it clear that you should ignore my posts because I don’t care to argue with someone who’s foaming at their mouth. I have enough borderline personality disorders I have to deal with in my practice, but at least I get paid for that.
STAY AWAY. I already told you once.
5 Likes
Aspirin is a well studied drug. Not a supplement. Just because it is easily available does not undermine its efficacy. It is useful for various conditions, least of which may be for heart disease. Many people on this forum have chosen to drop it and add it back based on recent studies. Can you offer clarity or not on risk/reward usage?
2 Likes
约瑟夫
#64
FWIW
There is a way to block(for your view/reading] posting you do not “care for”
A member posted how on a thread on this forum.
Find and repost?
1 Like
Aspirin is a well studied drug. Not a supplement
I never said it was. In fact this came up when we were discussing statins.
Just because it is easily available does not undermine its efficacy.
I have never ever said that it does.
It is useful for various conditions, least of which may be for heart disease.
I posted that twice already - it should be used for a GOOD INDICATION.
Many people on this forum have chosen to drop it and add it back based on recent studies. Can you offer clarity or not on risk/reward usage?
Everyone should make their own decision based on their situation and after a discussion with their doctor.
I was simply making a point that doctors are more careful in recommending aspirin for their patients because of the risk was underestimated and benefit overestimated in the past. THAT IS ALL.
3 Likes
Ah, one can only hope they are as harmless as a placebo. There is already mounting evidence that are NOT necessarily harmless. Unfortunately only very large studies can tease those small effects out.
The case studies especially presented by people on this forum who likely already live an incredibly healthy lifestyle by American standards are not very helpful.
It reminds of this News story.
I wonder how many people on this forum would take up drinking whiskey based on that claim.
3 Likes
That would be helpful. I looked for the block/ignore feature in my settings, on the post setting and on “their” profile and could not find any such feature.
At the same time I would like to be able to defend myself against any slander posted, so maybe it’s for the best.
1 Like
To mute someone, or ignore their posts, just click on their avatar, then click on as below in the image and choose “mute” or “ignore” on the right side under the message button. Let me know if you have any problems on this (I’ve never used it).
3 Likes
I appreciate your response. I would say in my “situation” aspirin has been very valuable with long-term use. And broadly as an anti-aging drug. My view is that its benefits have not been overestimated but I still seek clarity about its risks so it can be used safely. I have a great doctor and certainly will ask her opinion. But I think like most general practitioners she wouldn’t offer a view for anti-aging.
3 Likes
