#16

Again, when you start preaching, you should take into account who you are preaching to. All of that long winded post is old hat here. Show me a post here that recommends taking Vitamin E. I haven’t seen one (not saying that one isn’t buried here somewhere).
And I’m not taking 100+ supplements…if you want to argue that case, take it up with Bryan Johnson.

#17

I never said you did, in fact my original comment had nothing to do with you and you are the one that brought up Bryan Johnson. Not sure why are you so triggered ? Maybe you need some Ashwagandha in your stack.

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#18

I have no issues with doctors, PHDs and researchers coming on here and sharing their knowledge, in fact I think its a huge help. I appreciate the knowledge and reminders. I find that for me its easy to get too optimistic about the latest, greatest new research and get enthusiastic about trying things.

Sometimes I get busy and don’t do my blood testing as much as I think I should, etc. - or have missed some research that shows a new variable to watch for or new test to check occasionally.

I try to be open to knowledge wherever it comes from - and I appreciate the participation of medical experts here; the people who have spent their lives studying medicine and learning with their patients.

The doctors and researchers who are coming here are not the typical doctors that we see in primary care… these are people I think who are much more like us, people pushing the envelope a bit and open to learning, but also have much deeper knowledge of the biology, pharmacology and risks, so I think we have a lot to learn from them.

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#19

Interesting thing is they never mention the dose of the man who OD’d on vitamin D. They do mention that his blood levels were 380 which is the maximum value the test can test for (so it may have been even higher!) When I was taking 5,000 IUs a day, I registered a 30 which was 1 pt away from deficiency. I want to get to 50, so I’m taking 10,000 IUs a day (0.25 mg).

I’m pretty sure the extra 0.125 mg (5000 IUs) won’t pop me up into the danger zone. I’ll know for sure this summer when I have it tested again. The problem is that everyone’s biologies are so different. I am probably an under-absorber of vitamin D so I need to take more.

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#20

Actually, I am trying to emulate Bryan Johnson’s stack. I am of similar age and size so I think his stack may be what I should be using. I am thankful that he’s testing out all these supplements. Thanks, Bryan for being my guinea pig!

image

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#21

Neither do I. In fact I have no issues with anybody based on their titles, names, avatars or public profiles. What I pay attention to, is what they say. Now, let’s go back and take a look:

From his post where Bryan Johnson enters the conversation (yet he says i brought up Bryan Johnson). Then he says:

Now if he’s joking, fine, I joke alot. But he’s not joking. He’s an expert, but David Sinclair and Bryan Johnson’s team are not.Then he makes his long post against vitamin E. Did you find it useful? Who does he think we are?
So maybe you think I have something against @Dr.Bart . Well, I would refer you to this thread:
https://spotify.localizer.co/t/finasteride-delays-atherosclerosis-progression-in-mice-and-is-associated-with-a-reduction-in-plasma-cholesterol-in-men/12336?u=ng0rge
where he viciously attacked @DrFraser .Oh, that’s right…he deleted those posts. But I guess doctors attacking other doctors is OK.

#22

I value both sides of the argument. Sometimes we can get caught up in a positive feedback loop and it’s good to hear the arguments from the other side. After hearing both sides of the argument, I feel that I make a better choice. So I am glad for people like @Dr.Bart and @DrFraser But, let’s remember to go easy on the people and hard on the science.

That D@mn vitamin E pisses me off though. :angry: :wink:

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#23

Now you are out of line. If you can’t distinguish between a debate and “a vicious attack” maybe you shouldn’t be posting on these forums. In fact you never actually even attempted to debate me on any of my statements on this thread, you went straight for ad hominen… which judging by number of posts you made actually feels like “a vicious attack”.

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#24

Back this up. Proof?
I’m not the only one here that’s paying attention. Other people saw your deleted posts against @DrFraser before you deleted them. I have no knowledge of @DrFraser other than seeing his posts here but your posts were certainly out of line. The truth is out there.

#25

On the substantive issues, however, I do think the science is settled against supplementing with a lot of vitamin E.

I probably have hit the highest vitamin D levels of people on this forum with a tested 25OHD serum level over 400 nmol/L (which is the UK units - USA units 160 ng/ml) for about a week. I accept entirely that this is too high and there are a number of documented cases where people have suffered (and a few died) from hypervitaminosis D.

There is a story about David Sinclair and Resveratrol supplements, but I have not really bothered to look at it. I don’t myself take resveratrol because it is a cox-1 inhibitor.

I am heavily into skewing my inputs with various supplements etc, but on an evidence and testing basis.

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#26

Yes, I try to get my family to look at their annual bloodwork, but they just won’t do it. Instead, they just trust the doctor to discuss problems. But doctors have limited time, many patients, often miss emerging problems, and certainly make no attempt to optimize normal bloodwork numbers.

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#27

ad ho·mi·nem

  1. (of an argument or reaction) directed against a person rather than the position they are maintaining.

I have something against @Dr.Bart…he viciously attacked @DrFraser

That is definition ad hominem. Adding a straw man by claiming that I “viciously attacked” is a nice touch. You also heavily rely on appeal to authority fallacy in previous posts.

When comes to debate @DrFraser, I chose to retract some of my posts because at that time I already made my point and further debate was moot. Sometimes you have to agree to disagree. There were no vicious attacks and I hope the moderator would step in when that happens. I think I exercised a good judgement by ending a pointless debate (like this one) and I hope that serves as an example of civility for you.

Anyway, I encourage you to put me on the ignore list. I am highly skeptical person and tend to question assumptions. I really don’t care to have any further discussions with you.

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#28

When first correlation studies came out with low Vitamin D about 2 decades ago, we were very excited because it seemed like an easy and cheap OTC remedy. Unfortunately as the correlation studies mounted linking low Vitamin D with numerous medical conditions the interventions studies pretty much failed one after another. My only critique of the studies is that a lot of them had subjects take vitamin D irregardless of the serum level. Now I am a lot less enthusiastic about it, I still test it but only recommend replacement when USA unit level is under < 20, some patients choose to replace at higher levels. I never use the high dose replacements 50,000 I.U weekly, just very conservative dosing. Physiologically for humans natural vitamin D production was historically cyclical through out the year in the higher latitudes. I also wondered if daily dosing for fat soluble agent is the right way, I QOD dose it for myself.

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#29

My own (n=1 anecdotal) experiments point to a mild toxicity of unmetabolised cholecalciferol. Hence I would suggest daily dosing rather than a weekly bolus. Interestingly trials with monthly bolus have not produced good results.

My view is that we have evolved to handle an annual cycle of food feast and famine which the body controls through the vitamin d receptor.

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#30

I just went back and carefully reread the Worth article that is the subject of this thread. I highly recommend it (and rereading it) as an excellent overview of what’s happening in the longevity movement. The only thing I would have added is a little more about developments with Epigentic clocks ( mentioned along with Horvath and Levine).
This is the article that I would send to friends who ask about longevity, metformin and rapamycin. I’m going to send it to my sister who is a naturapath (no, not a psychopath). Also a nice mention of @John_Hemming favorite topic.
" Pollution, radiation, bad diet, lack of exercise, and other stressors can damage both DNA and epigenetic mechanisms. Shelly Berger and colleagues are studying a therapy for nerve cells, using an unspooling enzyme called Acetyl Co A synthetase. “That leads to turning on genes that are involved in learning and memory and creating new circuitry in the brain,” she says."

#31

Having read this I thought I would look up the reference from the OP. That leads to

ACSS2 and ACLY are both part of the Acetyl-CoA metabolic pathway. ACSS2 recycles acetate and ACLY recycles citrate.

I don’t know why they use the adjective “unspooling”.

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#32

John, I have to say that I think you are on to a hugely important aspect of aging. I’ve done a lot of reading on gene expression, transcription, translation and the citrate cycle. I really liked that they started the Worth article with a list of the 12 hallmarks of aging and it’s something that we should all keep in mind as we evaluate our approach.

#33

Thank you for this. Looking at it simplistically if the genome starts failing to function (which is the basis of my hypothesis) then lots of other things would go wrong.

The more complex question is what can be done to mitigate this and what the consequences are of doing that. That is where my personal biohacking experimentation (and to a lesser extent those who are working with me) is going.

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#34

This is the way.
Add some good sleep and you are 80% there.

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#35

That is the question as to 80% of what. Is it possible to achieve more in improving than what you seem to think is possible. The key question here is what evidence would be required to prove more is possible today with interventions used today.

My own view is that we need to identify functional tests to monitor this.

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