J0hn
#1
A single dose of the drug, called zilebesiran, can control the condition for up to six months, with few side effects, and could end daily tablets
6 Likes
jakexb
#3
RNAi is having a big day today seriously. Blood pressure and cholesterol just became extremely occaisional injections rather than daily pills.
1 Like
The question is, how long until it goes mainstream?
Arhu
#5
No thanks, few side effects unless you are one of the unlucky ones and then you are stuck with 6 months of side effects
JuanDaw
#6
Effect is modest.
Single doses of zilebesiran (≥200 mg) were associated with decreases in systolic blood pressure (>10 mm Hg) and diastolic blood pressure (>5 mm Hg) by week 8;
That is achievable with exercise, and other natural interventions.
adssx
#7
“>10 mm Hg” is not “modest”: it’s a massive effect. Indeed: “Most antihypertensive drug lower systolic blood pressure by around 10 mmHg, which reduces stroke and heart failure by about a quarter.” ( Efficacy and toxicity of antihypertensive pharmacotherapy relative to effective dose 50 - PMC )
For people who cannot control their BP with exercise and diet only, it could be a life saver.
3 Likes
LaraPo
#8
