I see I made the video in June, 2023, so I would have been 50. But if I had waited a month or two I would have been 51. I didn’t look for the month of the video when I wrote that.
I was essentially 51, but not quite…
5 Likes
The reason I am including Taurine is because I generate scar tissue (internal)
My body tries to protect me from foreign objects like knee replacement parts, and generates dysregulated fibrotic tissue that restricts range of motion and causes severe SEVERE pain.
Guess what?
Taurine is anti-fibrotic
Good for all
Of you who may end up with fibrosis I heart, lung, or liver tissue. Important to know.
Rapamycun used to cover heart stents to protect them from generating the same tiype of fibrosis
That is actually why I was interested in Rapamycin in the first place - to help me with the fibrotic tissue I generate - called “ Arthrofibrosis”. Now I learn that Taurine is also a help - you can bet I will be taking it!!!
6 Likes
A lot of that fibrosis can contain senescent cells as well. So, yes, both taurine and Rapamycin should help with that!
A main driver of fibrotic disease is cellular senescence, a state in which cells lose the ability to divide, alter their function, and secrete various pro-inflammatory and bioreactive molecules collectively called the senescence-associated secretory phenotype (SASP) (Hernandez-Segura et al, 2018).
Cellular senescence, p21, and the path to fibrosis - PMC).
We argue that targeting senescent cells , with senolytics or senomorphs, is a viable therapeutic target in fibrotic diseases which remain largely intractable.
https://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(24)00134-5
Taurine ameliorates cellular senescence associated with an increased hydrogen sulfide and a decreased hepatokine, IGFBP-1, in CCl4-induced hepatotoxicity in mice
http://www.sciencedirect.com/science/article/pii/S2213231725001533
Thank you for your Taurine information above!! It’s surprising how helpful it is when looked into. I should not have been surprised by the Arthrofibrosis following my first knee replacement. I had experienced a number of fibrotic related type problems when I was younger: Endometriosis, frozen shoulder, and fibrocystic breast disease. An enterprising doctor here in town learned there was practically no iodine in the soil around the Great Lakes, so he conducted a study. When he provided me (and other subjects) with iodine (I think it was the atomic form, but I’m not sure) after about a year, my Endometriosis and my fibrocystic breast disease became much more normal. Unfortunately, he died of cancer, and his work was not promoted by other doctors. After that knee replacement experience, I have included iodine in my supplement list. That is helping with this revision, I think. Thank you again!!! I read all of that information very carefully.
4 Likes
Started taking Taurine a few months ago, and in spite of not being able to weight bear for a sustained period (knee revision surgery 3 months ago), my bone density test showed improvement, even though I have mostly forgotten my Residronate because it’s only once a week. Interesting test result!!
3 Likes
Molecular basis of human taurine transporter uptake and inhibition
https://www.nature.com/articles/s41467-025-62857-w
3 Likes
Not very long, so I’m posting it in full.
GPT-4o mini. The prompt was: “please compare osmotic properties of taurine and creatine in the human body”
| Property |
Taurine |
Creatine |
| Osmotic Function |
Acts as an osmolyte, helping to stabilize cell membranes and protect against osmotic stress. |
Functions as an osmolyte, particularly in muscle cells, aiding in hydration and cellular function. |
| Concentration |
Found in high concentrations in the heart, brain, and skeletal muscle. |
Primarily concentrated in muscle tissue, with smaller amounts in the brain and other tissues. |
| Mechanism of Action |
Stabilizes proteins and cellular structures, influencing ion transport and cell volume regulation. |
Increases ATP availability, which can influence osmotic balance and hydration in muscle cells. |
| Physiological Role |
Involved in bile salt formation, neurotransmission, and antioxidant defense. |
Plays a crucial role in energy metabolism, particularly during high-intensity exercise. |
| Hydration Effects |
Contributes to cellular hydration and may help prevent dehydration during stress. |
Enhances water retention in muscle cells, promoting increased muscle volume and performance. |
| Impact on Osmotic Pressure |
Helps maintain osmotic balance in cells, particularly under stress conditions. |
Affects osmotic pressure by increasing intracellular water content, which can enhance muscle performance. |
Taurine and creatine both exhibit osmotic properties that are vital for cellular function, particularly in muscle and brain tissues.
Taurine
Taurine acts as an osmolyte, stabilizing cell membranes and protecting cells from osmotic stress. It is particularly concentrated in the heart and brain, where it plays roles in neurotransmission and antioxidant defense. Taurine helps maintain osmotic balance, especially during stress, contributing to cellular hydration.
Creatine
Creatine, on the other hand, is primarily known for its role in energy metabolism. It increases the availability of ATP, which is crucial during high-intensity exercise. Creatine also influences osmotic balance by promoting water retention in muscle cells, enhancing muscle volume and performance.
Both compounds are essential for maintaining osmotic balance and cellular function, but they serve different primary roles in the body.
1 Like
amuser
#131
lol, who said this
And I don’t get the ‘OmG iTs taKInG uP sPAcE!’ complaint. (Well, if you are on dial-up, maybe I do.) Apparently some people are severely put upon by scrolling.
Anyway, if the last hold-out is on board, sell everything.
Oh, yes, I was awaiting your attention when I posted this, I’m glad to see that I anticipated your very predictable MO and here you are right on schedule. And I apologize for having made you wait anxiously for so long before obliging, I know it’s been a long wait, but here you go. Alas, you didn’t notice my explanation about the reason for posting as it relates to readability vs walls of text. Posting anything that is short and to the point here is an equivalent of quoting - when we post a study for example, we post a short quotation (if very short, in full), not the entirety of the study, we put a convenient link for the latter. Now you’re welcome to wait until I post walls of text from AI - that way you can assure yourself a good date with “never” before saying “who said this”.
I do wonder though why you decided to post your highly anticipated faux “gotcha”, not in the dedicated thread that I created specifically to discuss this issue (note: discuss with community, not attempt to dictate, which for some reason you took umbrage with), and instead put in this completely OT noise in the taurine thread - however, I don’t want you to feel unnoticed, so here’s my acknowledgment right after your comment. Enjoy!
3 Likes
I had to search through your posts just to give it a heart because I agree wholeheartedly…
1 Like
