#41

Unless you try to use amyl nitrate or someone thinks you’re having a heart attack and uses sublingual nitroglycerine, in which case one can experience a serious (fatal?) drop in BP.

#42

My doc had me agree to no more than one every two days, I’m 74. Cialias 20mg tabs.

I’m apt to use 5mg (1/4 of a 20mg) or 1/3 tablet. I call sildenafil and tadalafil the 3-step med. Snort a 12-hour decongestant, take some acetaminophen for the headache and some antacid for indigestion. YMMV.

Interestingly I took quite a bit more (20mg of Cialis, or 20mg of Sildenafil) a decade + ago and over the years the dosage that I’ve needed for ED has dropped radically from 20 >10> 1/3 tab > 1/4 tab to really not necessary these days. 12 years ago my lipid profile was awful, today “brilliant.” I consider the “penimeter” the indicator of health of a man’s circulatory system and over 12 years I’ve seen enormous improvement.

I just came across the concept as using it for longevity and landed here. What dosages are considered good for that? With the side-effects I can’t imagine taking, everyone agree w/ Dr. Fraser’s post above?

Btw…it’s never affected my BP noticeably but nothing really seems to affect that… Losing 54lbs, aerobics… strange (but I’m old…74) I’d love to go off one of the three BP meds I’m on.

BTW, why buy 5mg when you can chop a pill into half/quarters, or pulverize it and even come up w/ 2.5mg. OffshoreCheapMeds from Pharmacychecker.com at $0.37 / 8 = 5 cents a dose for 2.5mg. It’s neither critical dose nor is it coated as far as I know.

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#43

Is it a cramp-like pain that you get? That’s what I get in a leg, occasionally a foot. Severe pain waking me up, I have to walk before the cramp goes away. This has been 2-3 nights a week the last month or two, been on tadalafil for 6-8 months.

#44

Try upping magnesium.

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#45

I will also put this question in this thread.

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#46

Three clinical trials found that oral administration of tadalafil, a PDE5 inhibitor, reduced MDSCs and restored antitumor T cell immunity in patients with head and neck squamous cell carcinoma [14,15] and metastatic melanoma [16].Oct 10, 2018

No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma

I wonder if someone read this, a bit too quickly and came to an odd conclusion about it causing melanoma:

Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe)

I know plenty of folk who might look at that and say: “OMG, Tadalafilr causes metastatic Melanoma.”

The reality is quite otherwise and the take-away is:

For those with metastatic Melanama (this article) says it’s ok to use Tadalafil.

10.1080/2162402X.2017.1326440

Take a look at this:

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