#143

Find a new doctor :man_facepalming:

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#144

I guess you might see if low dose sildenafil, probably a couple of times a day, microdosed has less effect on the blood pressure in your case? Certainly with it’s shorter half life, if wanting a decent level in your system most of the time. See what you can negotiate with your doctor.

This article talks about postural hypotension in older individuals. It’s pretty nasty in regard to mortality and morbidity increase.

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#145

Hey thanks for that info.

I should have asked him about cutting the dose to 2.5 but didn’t at the time of the follow up because the doctor was pretty busy.
I might ask him about both a lower dose and also your suggestion.

Will also keep an eye towards the hypotension but it was not there at the follow up. Evidently tadalifil can cause or contribute.
I’ve had no issues with balance, dizziness, or anything else related.

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#146

Who are you ordering them from?

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#147

I have a pill splitter but the pill cracks into pieces when I try to cut it into 2 lol

#148

got mine from India a they cut fine. The shape is a bit elongated in one end but still easy to cut. The pieces may not be all exact same size, but pretty close for example one piece might be 3mg and another one 3.7 but for most part they cut just fine.

IMG_5219
IMG_52191920×2560 434 KB

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#149

exactly the same one as mine … lol… i was hoping for a clean cut … but alas, they are too brittle. Thx for sharing.

#150

Your cutter might be dull. I even cut mine with a pocket Swiss knife at times and they cut ok.

#151

I ordered from Jagdish Nikose rlhealthcare1928@gmail.com
I do all of my transactions by email only.

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#152

Claude AI’s response when I asked if 2.5mg Tadalafil reduced cardiovascular risk

“Tadalafil’s potential impact on cardiovascular risk is a complex topic with ongoing research. Here’s what we currently understand about 2.5mg tadalafil and cardiovascular risk:

  1. Potential benefits:

    • Improved endothelial function: Tadalafil may improve the function of blood vessel linings, which is important for cardiovascular health.
    • Blood pressure effects: As mentioned earlier, it can cause mild reductions in blood pressure, which might be beneficial for some individuals.

  2. Limited direct evidence: There’s no strong evidence that 2.5mg tadalafil directly reduces overall cardiovascular risk in the general population.

  3. Specific conditions:

    • Pulmonary arterial hypertension: Higher doses of tadalafil are used to treat this condition, which can indirectly benefit cardiovascular health.
    • Diabetes: Some studies suggest tadalafil might improve endothelial function in diabetic patients, potentially offering cardiovascular benefits.

  4. Indirect benefits: By treating ED and BPH, tadalafil may indirectly contribute to better overall health and quality of life, which can have positive cardiovascular implications.

  5. Safety in cardiovascular patients: Tadalafil is generally considered safe for many patients with stable cardiovascular disease, when used appropriately.

  6. Not a primary prevention tool: Tadalafil is not prescribed specifically for cardiovascular risk reduction.

  7. Ongoing research: Studies are still exploring the potential cardioprotective effects of PDE5 inhibitors like tadalafil.

It’s important to note that while tadalafil may have some positive effects on cardiovascular health markers, it’s not a substitute for proven cardiovascular risk reduction strategies like exercise, a healthy diet, smoking cessation, and appropriate management of conditions like hypertension and high cholesterol.

Always consult with a healthcare provider for personalized advice on cardiovascular risk management, as individual factors play a significant role in determining appropriate treatments and strategies.​​​​​​​​​​​​​​​​”

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#153

Your query inspired me to use a similar query to OpenEvidence, which is primarily medically oriented. I use sildenafil because I am a fan of it. It was the one used in studies and has a shorter half-life, so dosing is less problematic. The bold highlight is mine.

Does daily sildenafil consumption reduce all-cause mortality in males?

"Expanded question: Does daily sildenafil consumption reduce all-cause mortality in males, specifically in those with conditions like pulmonary arterial hypertension or chronic heart failure?

Yes, daily sildenafil consumption can reduce all-cause mortality in males with conditions like pulmonary arterial hypertension (PAH) or chronic heart failure (CHF).

For patients with PAH, several studies have demonstrated that sildenafil therapy is associated with improved survival rates. For instance, a study by Zeng et al. found that the 1-, 2-, and 3-year survival rates in the sildenafil group were significantly higher compared to the conventional treatment group (88%, 72%, and 68% vs. 61%, 36%, and 27%, respectively).[1] Additionally, a randomized, multicenter study published in Circulation showed that higher doses of sildenafil (80 mg TID) were noninferior to lower doses (5 mg TID) in terms of all-cause mortality, with a hazard ratio of 0.51, indicating a potential survival benefit.[2]

In the context of chronic heart failure, the evidence is more mixed. While sildenafil has been shown to improve exercise capacity and hemodynamic parameters in patients with heart failure and secondary pulmonary hypertension, its impact on mortality is less clear. A meta-analysis by Zhuang et al. indicated that sildenafil improved hemodynamic parameters and exercise capacity in heart failure patients, particularly those with reduced ejection fraction, but did not show a significant impact on all-cause mortality.[3]

In summary, sildenafil can reduce all-cause mortality in males with PAH, but its effect on mortality in chronic heart failure patients is less definitive and requires further investigation. Always consult with a healthcare provider for personalized medical advice.

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#154
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#155

Alex, I’ve been taking 5 mg tadalafil for more than 5 years, always with a meal. The benefits for BPH symptoms overrides the stuffy nose problem for me. Taking it in the evening always exacerbated the stuffy nose problem which made sleeping difficult. So, I moved to taking with lunch which helped a lot. I also use diphenhydramine (yes, I know it’s not a good thing) at night to help with sleep which tends to resolve the stuffy nose problem because of it’s antihistamine effect. Recently, I discovered that Afrin nasal spray (I use a cheaper version) quickly resolves the stuffy nose problem if needed, which it rarely is.

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#156

AdrianK, Try using a single-edge razor blade.

#157

Anyone tried even lower than 2.5mg? Like 1.25mg? I want to make this work but I really don’t want side effects. I just don’t know if 1.25mg would even do anything as I don’t think it’s really been studied.

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#158

Never tried 1.25 but I could NOT see much of a difference between 5mg, 10mg, and 2.5mg in terms of benefits. It felt almost the same on all three different doses, but the side effects were more pronounced as dose went up, so while I haven’t tried 1.25mg I think the side effects will be minimal if any, still you might reap same or majority of benefits as if with higher doses. I would actually preferred to only do 1.25 myself but I just so happened that I bought 20mg pills, and it is very hard to cut it in over 10 pieces. If I’d ordered 5mgs I would think it is easier to cut in 4. I might order some with my next order, even though i have at least 5 years of the bigger dose.LOL

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#159

Why anyone is even effing around trying to figure out the optimal tadalafil dose, especially trying to cut a tadalafil tablet into 4,10, or 20 pieces, is ridiculous on many levels. You are searching for the optimal amount when there isn’t one.

First, the actual life extension study involved sildenafil, not tadalifil.
Second, the effective dosage for sildenafil, regarding heart failure, etc., is quite broad.

So, for your own reasons, you want to take tadalafil?
Unless the tadalafil dose you are taking is causing you some unpleasant side effects, you are probably overthinking this.

#160

Nice meltdown. Maybe your black market peptides are having an effect on your cognition.

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#161

I think it is a good idea for any drugs to find the lowest effective dose. These ED drugs do come with some nasty sides, such as headaches, flu-like symptoms, and acid reflux and I experienced them all myself, less so on lower doses.

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#162

Unless the tadalafil dose you are taking is causing you some unpleasant side effects, you are probably overthinking this.

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