#62

I’m considering moving my 2.5mg to bedtime to reduce the need to wake up to urinate. I have been taking it in the morning with breakfast pre workout for the NO boosting effects.

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#63

Luke, you bring up a good point.

Having a firm member all night… now that I think about it… I never get up to pee after I go to bed until I wake up in the morning to shower. I take my tadalafil at night with all of my medications (rapamycin… finesteride, minoxidil), so they can act while I’m asleep in a rested state.

My wife gets up several times. Never considered my naughty bits activity keeps you from feeling the urge.

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#64

If you do, It will be interesting to hear how you respond. Citrulline in small doses improves my sleep.

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#65

Is this a guess or did you find research that lead you to do this? I tend to take everything as far from sleep as possible to avoid any disturbance, but that’s my guess.

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#66

That’s a good question.

There’s no research based on it, except for my own physical well being. By nature … like my mother…I’m a very, very light sleeper. Any sound wakes me immediately.

I have no sleep issues taking my nightly finasteride, minoxidil and tadalafil. All good.

The weekly rapamycin at night maybe a little less sound sleep… and a bit foggy until noon the next day. I think the fogginess is to be expected. Because you’ve just set your whole body on alert that you’re starving in every single cell.

I have found a small bite of 420 gummy on my rapamycin night keeps me out til morning… with great deams. :+1:

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#67

My only concerns are potential GERD and stuffy nose making it more difficult to sleep

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#68

GERD is more harmful than one trip to the bathroom at night. I personally take it first thing in the morning and only 2.5 mg, which is clearly enough for me.

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#69

That"s interesting because my dosing of rapamycin after 3 to 6 months got rid of my dysphagia, which was related to probably hiatal hernia or acid reflux.

GERD…digestive disease in which stomach acid or bile irritates the food pipe lining.

For me, the rapamycin repaired the nerve cells that was causing the problem of choking at meals, which also was a little bit related to acid reflux.

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#70
  1. doxylamine supposedly induces less tachyphylaxis than other H1’s/ACs, it’s OTC and cheap as dirt
  2. for maintaining sleep you don’t necessarily want a shorter half-life, induction is a different story
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#71

Does any of you get bloodshot red eyes from tadalafil?

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#72

I got blood shot eyes… headache and a bloody nose from viagra, but never any these from to tadalafil.

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#73

I wonder what would have caused a bloody nose from Sildenafil

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#74

It was usually a bit after use… probably how viagra works concentrating blood in ones smaller blood vessels. Nose being pretty delicate. Definitely, did not like the headaches or bloodshot eyes.

Tadalafil no issues.

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#75

Question: Given the cause of action is a chain that leads to increase nitric oxide (NO) as the ultimate result producing the wide range of benefits, why not pursue NO more directly so as to avoid adding another med to the polypharmacy stack? For example, (1) tape the mouth closed at night forcing nasal breathing while sleeping, and (2) commit to nasal breathing only during exercise like running and cycling. I don’t have the research handy, but I’m guessing other like Joseph Lavelle have at least pieces of the relevant research. Seems like that would be a natural, no-brainer way to produce the desired benefit, but maybe I’m missing something…

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#76

Here’s a paper from Dr Dallam on nasal breathing during exercise for brain health. He say it’s probably the same benefits the heart.

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#77

Has anyone seen any research allowing us to compare the benefits of a nasal breathing lifestyle (mouth taping during sleep, nasal breathing during exercise, and nasal breathing during regular daily life) against taking low-dose Tadalafil? They’re both games of increasing NO nitric oxide for the intended health benefit, but I have no idea how to compare those increased NO benefits. Anyone?

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#78

@Todd since they are not alternatives we can do both. Chronic nasal breathing offers many benefits that go beyond the scope of NO.

  1. Protection against lung damage via air filtering and moisturizing
  2. Reduced illness from capture of virus in nasal mucus
  3. Deep breathing mediated parasympathetic activation
  4. Diaphragm strengthening for greater breathing efficiency
  5. Higher arterial co2 for blood vessels dilation and better O2 exchange
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#79

@约瑟夫_拉维尔 Thank you for your reply.

I get the value-added benefits of nasal breathing. I’m already a fan. Thanks to your podcast and my snoring problem, incorporating mouth taping at sleep and nasal breathing at exercise has been life-changing… literally. I’ve been surprised at what a big difference it has made on so many levels.

Where I’m unclear is the value-added benefits of low-dose Tadalafil if one has incorporated the full suite of nasal breathing practices into their life already.

Stated another way, we’re all clear about the risks of polypharmacy. We may not be able to define or quantify the risks, but it’s clear that undefined risks exist whenever we add a med to our stack.

That polypharmacy risk results in a general policy of trying to minimize additions to my stack to minimize that risk, and only add something when the researched benefits point toward a reasonably clear expected benefit.

I can see the expected benefit of low-dose tadalafil reasonably clearly, but all roads point toward nitric oxide increase as the key actor in this game. NO is the lynchpin that is driving the bus (at least, that’s my admittedly non-expert read of the material).

Given the research subjects weren’t parsed for nasal breathers vs. mouth breathers, I’m not seeing any way to know how applicable the research results are to nasal breathers who are already taking in much higher than average NO relative to the study population.

Does disciplined nasal breathing provide a comparably similar benefit? Is there still value-add for low-dose tadalafil above and beyond disciplined nasal breathing?

I dunno…

4 Likes
#80

FWIW: I ordered a lifetime supply of both tadalafil (Cialis) and sildenafil (Viagra) from India. :grin:
They are dirt cheap from India so it didn’t seem worthwhile to pay more for shipping than the product, so I ordered a large amount of both.

I thought that tadalafil might be the better option but after a little more research, I found that the half-life of tadalafil is ~17,5 hrs which would cause a worrying amount of accumulation if taken daily.

I took tadalafil daily for about two weeks before I knew what the half-life was. Then I started taking tadalafil every other day. Then I started plugging this routine into the drug half-life calculator and I could see that this would still result in a high amount of tadalafil in my system over a few weeks. This is when I decided to take sildenafil instead.
Sildenafil has a terminal half-life of about 4 hours, so a dose of sildenafil would essentially be eliminated in 24 hours.
So now I take sildenafil 6 days a week taking one day off to prevent an accumulation.
My experience is that I had no side effects from Sildenafil, but I had some with tadalafil.

In addition of course sildenafil was used in the study, so for now, I will be sticking with sildenafil.

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#81

Perhaps take an even lower dose of Tadalafil to accommodate a daily dosing schedule? I do 2.5mg per day, although Sildenafil is also a good option

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