Perhaps I’m wrong. I thought most people were taking 8mg. Given its long half life that means you’re constantly topping up every week and will reach saturation without cycling. I take only 4mg myself. Means one day a week I’m completely clear of rapa by my calcs.
EDIT: I’m very light. 67kg.
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The highest frequency dosing is 6mg/week per our survey, but we didn’t ask the sex of the responder, nor the weight, so we really don’t have enough information to draw any conclusions…
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Right so 73% are taking 6mg or more. That’s quite in line with my impression from speaking with people directly. I would assume that a large majority of people both in here and on that survey are men from what we know about online forum participation in general. Guesstimating here but I think most are not flushed of their previous weekly dose by the time they take their next one. So risk of mTOR suppression becoming constant rather than intermittent.
Average dosage according to that chart is 8.27mg.
adssx
#14
What about the paper published on rapa use? (forgot its name…) I think the average dose was 6 mg/week there, and the overall distribution was lower than in this forum’s survey.
And indeed, weight matters a lot.
[EDIT: More than the dose, I found that the most impressive was the short duration of the study: after only 3 months of rapa use they saw these massive benefits!]
Senben
#15
How did they come with number of 5 years of prolonged fertility? If they say Rapamycin could decrees ovary ageing by 20% and average menopause age is 51 and average year of starting a period is 12, than this is span of 39 yeas of periods and 20% is 7,8 years.
Also, study lasted for 3 months, how they come to conclusion that it will prolong periods for approx. 5 years? The hypothesis that Rapamycin slows down ovarian ageing by suppressing numbers of released eggs from 50 to 15 per months is based on premises that there is a final number of eggs in woman ovaries and there are new researches which suggest there are ovarian stem cells in ovaries which can produce new eggs. There are woman who wrote on this forum about taking Rapamycin after menopause and getting they periods again which would not be possible if there was a final number of eggs in ovaries. Also, Rapamycin regenerates organs which can be maybe the case in ovaries too, so delaying menopause cold be also from this aspect, not only form “preserving” numbers of eggs in ovaries.by suppressing mTOR.
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adssx
#17
Thanks.
73 women (average weight 62 kg), 260 men (average weight 81 kg). Too bad the graph is in # and not %, and they should have given the doses per kg of weight as well, but anyway, both the median and the average for men and women seem to be around 5 mg/week, which is exactly what was used in this fertility study.
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Without disagreeing with this point, I would think the problem of a reduction in mitochondrial quality is also likely to be an issue. The reason paternal age is not as important to fertility as maternal age is that the paternal mitochondria are either destroyed or irrelevant in the quantity in the zygote.
I find it interesting that the human egg cells are created in the mother well before the mother herself is born:
I see that as a solution to the problem of gradually deteriorating mitochondria (which I personally see as a primary store of biological age). Hence for babies to be born young they need to come from egg cells which were created when the mother was an embryo and kept in a relatively quiescent state since then.
eli
#19
Females in the study were ( at least according to cited source) only up to 35 years old , so probably younger than several of us here…
I also understand none of them would have had side effects of headaches etc …I just had my 5 mg dose yesterday ( taken at 11.55 am ) and was totally out as of 16 pm until mid this morning due to atrocious headache 
(it felt like I was suddenly hit hard by the flu but luckily it mostly passed by now) Not sure this was since I paused it for 3 weeks ( had some 5 mg doses before with mostly just huge fatigue and a rash once in a while) but not sure if I will up my dose further . I guess it is ok to take ibuprofen or paracetamol against the headache? ( I did take some as I could barely move from the pain yesterday)
KarlT
#20
Would mean or median be of more use here?
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Eli, was this your first dose? or have you been taking it for a while and suddenly got a headache this time? Did you start low (1mg/week) and work up, like many of use do? What is the Rapamycin Dose / Dosage for Anti-Aging or Longevity?
Median would be in fairness. At a glance it looks like it’d be lower as well.
Senben
#23
There are more research saying that DNK fragmentation in sperm can be cause for infertility in couples. DNK fragmentation sperm analysis are now used in IVF clinics, before it was only sperm quality and quantity. Also age of a men has impact on lower sperm quality and quantity which can impact fertility… As, I already mentioned ovarian stem cells are a recently discovered type of cell than can give rise to oocytes in culture and produce healthy oocytes in vivo. The work of Harvard Sincalir Lab may overturn the dogma that a female is born with a set number of eggs that are simply lost over time due to damage and genomic instability. They goal is to identify genes and small molecules that can reactivate ovarian stem cells in vivo to treat premature ovarian failure, chemotherapeutic ovarian failure (in cancer patients) and extending the healthy and fertile period for women. https://sinclair.hms.harvard.edu/research
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Really interesting, different organs will respond differently to rapamycin but an effect in the 20% range with a relatively low dose is encouraging!
Women are having children later and later so if this becomes a serious treatment for that it could help mainstream it much faster and result in more studies, fingers crossed.
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I said paternal age was “not as important”. I accept that there are issues with paternal age. I accept also that there are a range of factors with sperm.
My point on eggs, however, is about mitochondrial quality. It may be that somehow you can get something to the eggs that improves their mitochondria without doing any harm to the mother. It may be that general mitochondrial improvements also improve the eggs. However, I do think it is scientifically settled and not so much a dogma that the eggs are created prior to birth of the mother.
Using this normal definition of dogma
Senben
#26
Please, take a look ta following link I already sent you:
https://sinclair.hms.harvard.edu/research
Go to the 5 paragraph:
Delaying menopause and reversing female infertility
You will see that news research suggests that there are steam cells in ovaries which can produce new eggs and that thinking that woman are born with finite number of eggs is scientific DOGMA.
This is from is from DAVID SINLAIR HARVARD LAB research. They also used word DOGMA.
Most of the words has poysemantic meanings which means that depending on context same word can have a little bit different meaning.
So for example MEANING of word dogma can be the following:
plural dogmas also dogmata -mət-ə 1. : something considered as an established opinion. 2. : a belief or body of beliefs concerning faith or morals laid down by a church.
So in this case DOGMA means SOMETHING CONSIDETED AS AN ESTABLISHED OPINION for example in science.
I accept that in the 9th paragraph it asserts something for which it gives no reference.
This is from the Sinclair lab as well. Hence I would wish to see a reference before taking such a claim seriously.
There are problems with different people using the same word to mean different things.
Whether it is true or not, however, does not mean that the issue of mitochondrial quality is not important.
eli
#28
Dear RapAdmin
This was my 4th dose of 5 mg ( truth be told the previous ones were during holidays so I could relax more where tired ) but it was my first time I felt so sick ( no skin eruptions though this time - for the moment 
) i started to feel better after +_ 26 hours and then it faded away quickly. It was really intense though.
Yes I worked my way up VERY slowly , from 1 mg ( started in April 23 and only had my first 5 mg at the end of June this year; always Rapamune Pfizer ). Personally I did very well starting with 1 mg and going slow as I had serious skin eruptions in the beginning with just 1 mg; but luckily it got much better and even disappeared () with time. It scares me sometimes to read that people here sometimes start straight away with 5 mg as you never know how body will react.
I guess there should be no problem taking paracetamol or ibuprofen correct in case of terrible headache shortly after dose ? Or would that be not recommended in combination with Rapamune ?
Thank you very much
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I’m not an expert on the topic, but checked the drug interaction potential. It seems paracetamol / acetaminophen has no interactions.
For some reason, they flag ibuprofen and naproxen interactions with sirolimus (rapamycin/rapamune) but the warnings are really vague, so I’m not sure how valid they are for most people…
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59vw
#30
Lots of people feel “sick” or under the weather after taking rapa. It’s not surprising, it mimics starvation. If you skip a few meals it doesn’t feel great either. All this to say I’m not sure the dose goal is to settle on a dose that you feel “great” after you take it. Some people have no adverse feeling when taking rapa but many get head aches, gi upset, ears ringing, altered sleep for a day or two, aphthous ulcers, skin acne. I also think your body adapts a bit and they become less noticeable over time. I refuse to call these “side effects” since I believe most are direct effects of rapa doing its job.
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