#21

Eli, was this your first dose? or have you been taking it for a while and suddenly got a headache this time? Did you start low (1mg/week) and work up, like many of use do? What is the Rapamycin Dose / Dosage for Anti-Aging or Longevity?

#22

Median would be in fairness. At a glance it looks like it’d be lower as well.

#23

There are more research saying that DNK fragmentation in sperm can be cause for infertility in couples. DNK fragmentation sperm analysis are now used in IVF clinics, before it was only sperm quality and quantity. Also age of a men has impact on lower sperm quality and quantity which can impact fertility… As, I already mentioned ovarian stem cells are a recently discovered type of cell than can give rise to oocytes in culture and produce healthy oocytes in vivo. The work of Harvard Sincalir Lab may overturn the dogma that a female is born with a set number of eggs that are simply lost over time due to damage and genomic instability. They goal is to identify genes and small molecules that can reactivate ovarian stem cells in vivo to treat premature ovarian failure, chemotherapeutic ovarian failure (in cancer patients) and extending the healthy and fertile period for women. https://sinclair.hms.harvard.edu/research

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#24

Really interesting, different organs will respond differently to rapamycin but an effect in the 20% range with a relatively low dose is encouraging!

Women are having children later and later so if this becomes a serious treatment for that it could help mainstream it much faster and result in more studies, fingers crossed.

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#25

I said paternal age was “not as important”. I accept that there are issues with paternal age. I accept also that there are a range of factors with sperm.

My point on eggs, however, is about mitochondrial quality. It may be that somehow you can get something to the eggs that improves their mitochondria without doing any harm to the mother. It may be that general mitochondrial improvements also improve the eggs. However, I do think it is scientifically settled and not so much a dogma that the eggs are created prior to birth of the mother.

Using this normal definition of dogma

#26

Please, take a look ta following link I already sent you:

https://sinclair.hms.harvard.edu/research

Go to the 5 paragraph:
Delaying menopause and reversing female infertility
You will see that news research suggests that there are steam cells in ovaries which can produce new eggs and that thinking that woman are born with finite number of eggs is scientific DOGMA.
This is from is from DAVID SINLAIR HARVARD LAB research. They also used word DOGMA.
Most of the words has poysemantic meanings which means that depending on context same word can have a little bit different meaning.
So for example MEANING of word dogma can be the following:

plural dogmas also dogmata -mət-ə 1. : something considered as an established opinion. 2. : a belief or body of beliefs concerning faith or morals laid down by a church.

So in this case DOGMA means SOMETHING CONSIDETED AS AN ESTABLISHED OPINION for example in science.

#27

I accept that in the 9th paragraph it asserts something for which it gives no reference.

This is from the Sinclair lab as well. Hence I would wish to see a reference before taking such a claim seriously.

There are problems with different people using the same word to mean different things.

Whether it is true or not, however, does not mean that the issue of mitochondrial quality is not important.

#28

Dear RapAdmin

This was my 4th dose of 5 mg ( truth be told the previous ones were during holidays so I could relax more where tired ) but it was my first time I felt so sick ( no skin eruptions though this time - for the moment :crossed_fingers:) i started to feel better after +_ 26 hours and then it faded away quickly. It was really intense though.

Yes I worked my way up VERY slowly , from 1 mg ( started in April 23 and only had my first 5 mg at the end of June this year; always Rapamune Pfizer ). Personally I did very well starting with 1 mg and going slow as I had serious skin eruptions in the beginning with just 1 mg; but luckily it got much better and even disappeared (:crossed_fingers:) with time. It scares me sometimes to read that people here sometimes start straight away with 5 mg as you never know how body will react.

I guess there should be no problem taking paracetamol or ibuprofen correct in case of terrible headache shortly after dose ? Or would that be not recommended in combination with Rapamune ?

Thank you very much

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#29

I’m not an expert on the topic, but checked the drug interaction potential. It seems paracetamol / acetaminophen has no interactions.

For some reason, they flag ibuprofen and naproxen interactions with sirolimus (rapamycin/rapamune) but the warnings are really vague, so I’m not sure how valid they are for most people…

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#30

Lots of people feel “sick” or under the weather after taking rapa. It’s not surprising, it mimics starvation. If you skip a few meals it doesn’t feel great either. All this to say I’m not sure the dose goal is to settle on a dose that you feel “great” after you take it. Some people have no adverse feeling when taking rapa but many get head aches, gi upset, ears ringing, altered sleep for a day or two, aphthous ulcers, skin acne. I also think your body adapts a bit and they become less noticeable over time. I refuse to call these “side effects” since I believe most are direct effects of rapa doing its job.

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#31

Of course , it was just not the “ normal “ feeling under the weather: I went from perfect to the feeling of a terrible flue or migraine ( you know when you feel so bad you wouldn’t mind dying) in just a few hours ( I am on rapa since April 2023 so over a year and built it up very slowly, in fact it was also my 4th dose of 5 mg without such extreme effect ) so I took too much of paracetamol ( forte, every 4 hours; it is supposed to be taken only every 8 hours) the hours that followed it ( am one of these persons that tries to take never anything, nor even for headaches or cold unless absolutely necessary) So I got a bit wary now of such an extreme effect, so sudden.

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#32

Another write-up on this rapamycin study in fertility:

#33