JeffW
#86
If you are at risk for colon cancer, like it appears I am, you should have regular colonoscopies to remove polyps. If you have one and you’re all clean, your doctor should provide you with a timeline as to if/when you should check again. I hope that people here don’t have cancer or polyps so they can avoid regular colonoscopies.
For me, I need one every 3.5 years. That’s just the way it rolls. I’d rather have a polyp removed instead of finding a malignant tumor a few years later. I’d recommend everyone to have at least one to find out if they are at risk or not. Or at least talk with your doctor about it.
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Right. Since I’ve had 3 clean colonoscopies over the last 15 years they now tell me to get one every 10 years. I’ve got other problems to make up for this one.
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From the article you cite: “NSAIDs: Do they increase my risk of heart attack and stroke?” " Aspirin doesn’t appear to be associated with a higher risk of heart attack or stroke"
As for other NSAIDs, they do not all have equal risk.
From the literature I have read, Naproxin has the lowest risk.
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Neo
#90
Can aspirin help protect against colorectal cancers?
A new study details how a daily dose could prevent or delay the progression of the world’s third most common type of cancer.
Now a new study published in the journal Cancer shows that colorectal cancer patients who took a daily dose of aspirin had a lower rate of metastasis to the lymph nodes and stronger immune response to their tumors. The research suggests that aspirin may be boosting the ability of the immune system to hunt for cancer cells.
“It is a rather unexpected effect, because aspirin is mainly used as an anti-inflammatory drug,” says Marco Scarpa, a researcher at the University of Padova, and one of the authors of the study. As Scarpa notes, this study suggests that aspirin may be playing a slightly different role by stimulating the immune system’s surveillance response, which can then prevent or delay the progression of colorectal cancer.
In a 2020 meta-analysis, which analyzed the results of 45 observational studies, researchers found that regular aspirin use was associated with less incidence of colorectal cancer.
A low dose, between 75 and 100 milligrams, was associated with a 10 percent reduction in the risk of developing colorectal cancer; a regular dose of 325 milligrams was associated with a 35 percent decline.
Other studies have shown a link between daily aspirin and a delayed progression, including a lower risk of dying in patients who had already been diagnosed with colorectal cancer.
https://acsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/cncr.35297
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A few other stories on the Aspirin study for colon cancer:
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New magic pills. We get some every 20 years or so.
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Neo
#94
@adssx have you seems more broadly across your lit review of flozins?
How much do people think this effect carries over to fully healthy people?
adssx
#95
I didn’t dig into SGLT2i and cancer much but whenever I found something interesting, I posted it here: Search results for 'cancer topic:91 @adssx order:latest' - Rapamycin Longevity News
Some studies are quite impressive indeed, but yes, mostly done in diabetic people. Would be good to do similar studies in non-diabetic people with CKD or HF (unless people with CKD or HF but without T2D have a higher risk of cancer?).
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Even more results on lung cancer
Results: SGLT2 inhibitor use was associated with significantly reduced mortality risk after adjusting for potential confounders (HR = 0.68, 95% CI = 0.60-0.77) with stronger association for longer duration of use (HR = 0.54, 85% CI = 0.44-0.68). Further, we found that SGLT2 inhibitor use was associated with a significant reduced risk of mortality regardless of patients’ demographic, tumour characteristics and cancer treatments.
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Just got the pathology report back from my colonoscopy. Instead of 2 polyps, there were 3.
In my most recent colonoscopy at the beginning of last month, the doctor found 3 tubular adenomas which each had a 10% chance of becoming cancerous. I’m glad they’ve been removed.
A 30% chance of having cancer within 5 years is not a good bet. It’s easier removing a polyp than cancer.
Next colonoscopy in 3 years.
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Btw are you taking SGLT2i?
Yup, 6.25mg empagliflozin daily but considering upping it to 25mg a day for weight loss. With my new salary I think I can afford the full dose 
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Is this equivalent to a 25 mg tablet split into quarters? I’ve been contemplating 12.5 mg every other day for almost full benefit per some studies, especially concerning sugar control. But I still need to take the plunge. How long have you been taking it? Can you share any pros and cons? the unpredictability of caloric output can be frustrating… #controlfreak 
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Correct.
I’ve been contemplating 12.5 mg every other day for almost full benefit per some studies, especially concerning sugar control.
Most of the benefit is seen at the 10mg dose already though the 25mg dose seems to cause increased weight loss so that what I’m considering.
How long have you been taking it?
2 months now.
Can you share any pros and cons?
Pros: I don’t seem to put on much weight anymore despite eating like a pig on weekends.
Contras: at higher doses I crave sugar.
Overall, if it wasn’t for the price, a great drug for kidney protection and weight control. I prefer it over acarbose.
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The high bio-available Curcumin knocked my platelets to below the lower level of the blood test range. It took some figuring but I narrowed it down to the Curcumin I was taking. I stopped the supplement and my platelet level moved back up. Something to be cognizant of. Cheers
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