One concern with statins is the impact on the liver, elevated liver enzymes and so on.
This is in people with chronic liver disease, but still nice to see that statins are a positive and not a negative, so perhaps statins might not be hepatotoxic in general?
Statin Use and Risk of Hepatocellular Carcinoma and Liver Fibrosis in Chronic Liver Disease
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2831392
"Question What is the association between statin use and the risk of hepatocellular carcinoma (HCC), hepatic decompensation, and fibrosis progression in patients with chronic liver disease (CLD)?
Findings This cohort study including 16 501 patients who were 40 years or older and living with CLD, statin use was significantly associated with a lower 10-year cumulative incidence of HCC (3.8% vs 8.0%) and hepatic decompensation (10.6% vs 19.5%). Lipophilic statins and longer cumulative statin use (≥600 cumulative defined daily dose) were associated with further risk reductions, and statin users exhibited a reduced likelihood of remaining in or transitioning to high-risk Fibrosis-4 score groups.
Meaning These findings indicate that statin use, particularly lipophilic statin use, and longer duration of statin exposure may reduce the risks of HCC and hepatic decompensation in patients with CLD."
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