#33

Professor Thomas Seyfried argues that some cancers (posssibly all of them) are driven by metabolic problems. Hence treating the metabolic issues is seen as one route.

Another is citrate
https://www.sciencedirect.com/science/article/abs/pii/S0304419X23001361

Another is melatonin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998229/

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#34

At some point I would go on the best psilocybin retreat I could find if that was me, and make arrangements for cryonics, cryopreservation, while trying something else to slow it down or halt it.

See the Marsh Chapel Experiment:

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#35

If it were me I would try to bring glucose/fructose intake to zero (maybe Acarbose helps here) and do a daily 1mg rapamycin. (And also look at John’s suggestions).
Good luck.

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#36

I can’t find all the articles but there has been a bunch of new stuff on Klotho.

https://www.sciencedirect.com/science/article/pii/S0083672916000261 - ** The Role of Alpha-Klotho as a Universal Tumour Suppressor**
https://www.sciencedirect.com/science/article/pii/S0301462218301212 - Antagonistic role of Klotho-derived peptides dynamics in the pancreatic cancer treatment through obstructing WNT-1 and Frizzled binding

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#37

In the book “Tripping over the truth”, which is about cancer over the years, he has a chapter about something called 3BP, which kills all cancer cells and leaves everything else alone. It spent decades unapproved and in legal limbo. I just typed it in and it looks like they can use it now:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103555/

I don’t know why everybody isn’t using it, just read the book and in there it looked like an amazing last ditch possibility. If you find out from somebody what the problem with it is, then let us know. I’m curious.

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#38

Don’t forget DAV therapy, which at full dosage is effective against most cancers in mice. Should work synergistically with IV Vitamin C (50g over 2 hours), daily if you can afford it, otherwise 1-2 times a week will still boost DAV : : My DAV* Therapy begins! *Doxycycline, Azithromycin and Vitamin C

If you cannot afford IV Vitamin C, instead try Lipo Vitamin C (Livon Labs or Renue by Science are 2 reputable brands, many other liquid emulsion based Liposomal Vitamin C are bogus), 1000mg every 3 hours : It doubles the plasma Vitamin C level vs regular Vitamin C and possibly increases intra-cellular Vitamin C by an even larger factor.

Also BDMC Curcumin (The Prodrome brand at Prodrome.com with 25% discount code PDC25, is the cheapest I have found) is very effective against Colon Cancer and somewhat effective against Pancreatic Cancer, though not sure how effective it is once the cancer is metastatic.

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#39

If I had cancer and nothing to lose, I would try;

to target the mitochondrial aspect of cancer and the following peptides to boost immune function;
glutathione, thymosin alpha 1, thymalin and thymogen alpha.

I would also use self made lipsomal vitamin C, 30g spread over the day and I would avoid all other carbohydrates to get in ketosis.

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#40

The two themes I’ve seen in any of the spontaneous regression stories I’ve seen are either:

  • absolutely zero carb diet
  • some sort of immune activation / rejuvenation

It’s so hard to know what specifics I would try myself, but I just wanted to note that those seem to be the major themes that come out of the unexpected success stories that I’ve seen.

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#41

Hi all
This is my first message on this forum. The situation with your father-in-law is really difficult. There is no clear solution. I don’t think there are any clinical studies on this. Therefore, you can only look for a very non-formal way out. I once read an article on GreenMedInfo.com a long time ago: Why An Alkaline Approach Can Successfully Treat Cancer. Article here: https://greenmedinfo.com/blog/why-alkaline-approach-can-successfully-treat-cancer#_edn6
The article is certainly entertaining, but I didn’t see anything new that could somehow surprise me, but below, in the comments to the article, one user with the nickname 777Thomas described his experience of treating stage 4 prostate cancer. Below is a quote from his first post:

Just saw this article and skimmed through it. Not that I need a cancer cure. But I did 9 1/2 years ago. I was diagnosed with late stage 4 prostate cancer with my PSA test showing 3,280 My bone scan revealed +120 tumors in my bones with one of them weakening my 5th vertebrae to the extent that I broke my neck. My oncologist and urologist thought I might live 3 more months if I was lucky.
When my PSA started doubling every 6 weeks they said the only left for them to do was admit me to a palliative unit where I could die in a few weeks. And get an unlimited supply of hydromorphine iv and OxyContin + Oxynorm - so I wouldn’t suffer from all the pain.

Great I thought, they’ve got it all figured out for me. But I wasn’t buying their BS and started searching the net for something I could do on my own. UCLA and Ceders-Sinai did a study using rats with human prostate cancer tumors In operated in their bodies. Half of the rats got daily shots of water and the other half got an injection containing the pepper molecule found in cayenne pepper called capsaicin. The rats getting the water injections started dying. While the other half getting the capsaicin injections were doing great. 80% of the tumors placed in their bodies were gone. The remaining 20% had all decreased in size.

So I took 8 capsules/day at breakfast. Starting with 1/2 qt. yoghurt then the capsules followed by the other half of the yoghurt. Waited about 1/2 an hour then I ate a large fiber rich breakfast.

After those 8 weeks of taking these cayenne pepper capsules every day I was to do a new PSA test. The resulting score was only 1.75!!! This really screwed with my oncologists head. She was unbelievably perplexed by this huge drop and asked me if I had changed anything in my life which could account for the score deviation. I lied and said no. (She made me retake all the blood tests again because she thought at the only reasonable explanation was a lab error -they screwed up because there was no way these values could be correct.

After letting my stomach and intestines rest for about 5 weeks I started the 8 week cayenne pepper cure again. After the second time my PSA dropped from 1.75 to <0.05 Or meaning it was so low that it’s undetectable!! And that’s where my PSA has stayed for almost 8 years now.

While I was living on the palliative care unit, where I was supposed to die, I met two other stage 4 prostate cancer patients. Like me they had nothing to lose so both of them did the cayenne pepper cure just like I did. And just like me, instead of just dying there, they were healthy enough to get permanently released. We all agreed, we must spread the truth/word about what happened to us.

Read his other posts in the comments.
This is what really amazed me. He developed a treatment protocol for himself and cured himself and his two friends.

He (777Thomas) ordered capsules from Amazon with the following request: cayenne pepper capsules
He chose capsules with maximum capsaicin (the active ingredient in cayenne pepper) among different manufacturers and took them according to his protocol.
In addition, if you type in Google: Capsaicin and pancreatic cancer, it turns out that he was absolutely right.
It is clear that in this case the concept: DOSE-EFFECT is not defined, and here it is possible that its protocol must be repeated.
These are the thoughts. I hope you find the right path and help your father-in-law.

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#42

AOH 1996 (very experimental cancer med).

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#43

At this point we are thinking about trying 1 mg of daily Rapamycin to slow the cancer cell growth plus the DAV therapy. If he can live several months longer, we’ll count it as a win. I think it’s not possible to cure it at this point. Thoughts?

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#44

Like previously posted here in this thread, it could slow down the cancer. But I don’t know at what dose.

“mammilian target of rapamycin (mTOR) is a very important serine/threonine protein kinase involved in the regulation of energy metabolism, cell growth, angiogenesis and other cellular biological processes.Rapamycin (sirolimus) is a selective inhibitor of mTOR kinase, which can inhibit the activation and proliferation of T lymphocytes to inhibit the immune response.Currently, mTOR inhibitors are also widely used in tumor treatment. Several studies have been performed to evaluate the efficacy of sirolimus in some solid tumors, and encouraging results are obtained. However, the existing studies on mTOR inhibitors and pancreatic cancer treatment are mostly phase I trials, with little evaluation of the efficacy. Therefore, the phase II clinical trial of rapamycin in the treatment of pancreatic cancer is very necessary.”

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#45

Would 1 mg of Rapamycin a day be enough? 2 mg? A big dose weekly? There’s nothing to lose, but I would like to take the most optimal bet.

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#46

If it were me I’d take it daily but start at 1mg for a few weeks and then see if any effects. If not then try 2g and again then see if any effects. If not then try the other end of the scale with 12-14mg fortnightly or 30mg once every four weeks. Again then see if any effects. Hopefully one of those shows at least a halt in progression which buys you time to try other things.
Keeping my fingers crossed for you - good luck!!

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#47

Does anyone know how much Rapamycin Dr. Blagosklonny is taking? I would like to give the same regimen to my father in law for his cancer. Thank you.

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#48

Thanks for the wonderful responses in other threads.

Dr. Sehgal took 1 mg of Rapamycin daily.

Cancer patients take about 10 mg Everolimus daily which translates to about 5 mg Sirolimus daily.

We may go with 6 mg equivalent or 2 mg + GFJ daily.

We will probably need 1-2 rest days each week. How many should he do?

Thoughts on this proposed protocol?

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#49

Can anyone comment on doing the DAV therapy (Doxycycline Azithromycin Vitamin C) and Rapamycin at the same time. Is it a good idea or not? Thanks for any input.

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#50

I am sorry for your problems. You are certainly a good and kind son-in-law.
I have done the DAV therapy twice. Once I stopped taking rapamycin the second time I was on my regular 1/week schedule. I had zero side effects or any subjective effects which I assume is because I don’t have any known cancer.

If I were to advise anyone, and I wouldn’t want to, who had a cancer problem that wasn’t being helped by conventional methods, I would take Dr. Blagosklonny’s advocacy and take the highest tolerable dose of rapamycin. His opinion papers indicate that he believes it is a cancer treatment.

As for the DAV treatment, I would follow the regimen advocated by Joseph.

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#51

It seems that Sirolimus (Rapamycin) can be effective at weakening cancer on its own. However, when a traditional chemotherapy is added, the effects are even greater. I wish we hadused Rapamycin in addition to chemo in the first place!

After consulting with the hospital, we are considering the last chemotherapy that they have available, TS-1 combined with Sirolimus. TS-1 converts to 5-Fluorouracil in the body. Unfortunately, the cancer may already be resistant to it as it was used in another treatment already. Still, we hope that the addition of Sirolimus will make the drug effective again. If so, then this could open up the door to trying other chemo drugs already used paired with Sirolimus to extend lifespan.

In the early-treatment experiment, the tumor growth rate was inhibited by 48% in the group treated by rapamycin alone, by 34% in the 5-fluorouracil-treated group, and by 60% in the group treated with rapamycin plus 5-fluorouracil compared to the control mice

There are already precedents set for Gemcitabine resistant cancers, such as adding Sirolimus, where the resistant cancers are affected by Gemcitabine more than non-resistant cancers due to the Sirolimus.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947835/

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#52

Perhaps consider

Our clinical trials looking into Fast-Mimicking Diet (FMD) and cancer prevention and treatment are ongoing. But if early results are any indication, it could be a powerful new weapon in the arsenal we have to fight, and one day defeat, cancer.

Papers etc here Cancer - Valter Longo can also check the latest clinical trials

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