#41

Hi all
This is my first message on this forum. The situation with your father-in-law is really difficult. There is no clear solution. I don’t think there are any clinical studies on this. Therefore, you can only look for a very non-formal way out. I once read an article on GreenMedInfo.com a long time ago: Why An Alkaline Approach Can Successfully Treat Cancer. Article here: https://greenmedinfo.com/blog/why-alkaline-approach-can-successfully-treat-cancer#_edn6
The article is certainly entertaining, but I didn’t see anything new that could somehow surprise me, but below, in the comments to the article, one user with the nickname 777Thomas described his experience of treating stage 4 prostate cancer. Below is a quote from his first post:

Just saw this article and skimmed through it. Not that I need a cancer cure. But I did 9 1/2 years ago. I was diagnosed with late stage 4 prostate cancer with my PSA test showing 3,280 My bone scan revealed +120 tumors in my bones with one of them weakening my 5th vertebrae to the extent that I broke my neck. My oncologist and urologist thought I might live 3 more months if I was lucky.
When my PSA started doubling every 6 weeks they said the only left for them to do was admit me to a palliative unit where I could die in a few weeks. And get an unlimited supply of hydromorphine iv and OxyContin + Oxynorm - so I wouldn’t suffer from all the pain.

Great I thought, they’ve got it all figured out for me. But I wasn’t buying their BS and started searching the net for something I could do on my own. UCLA and Ceders-Sinai did a study using rats with human prostate cancer tumors In operated in their bodies. Half of the rats got daily shots of water and the other half got an injection containing the pepper molecule found in cayenne pepper called capsaicin. The rats getting the water injections started dying. While the other half getting the capsaicin injections were doing great. 80% of the tumors placed in their bodies were gone. The remaining 20% had all decreased in size.

So I took 8 capsules/day at breakfast. Starting with 1/2 qt. yoghurt then the capsules followed by the other half of the yoghurt. Waited about 1/2 an hour then I ate a large fiber rich breakfast.

After those 8 weeks of taking these cayenne pepper capsules every day I was to do a new PSA test. The resulting score was only 1.75!!! This really screwed with my oncologists head. She was unbelievably perplexed by this huge drop and asked me if I had changed anything in my life which could account for the score deviation. I lied and said no. (She made me retake all the blood tests again because she thought at the only reasonable explanation was a lab error -they screwed up because there was no way these values could be correct.

After letting my stomach and intestines rest for about 5 weeks I started the 8 week cayenne pepper cure again. After the second time my PSA dropped from 1.75 to <0.05 Or meaning it was so low that it’s undetectable!! And that’s where my PSA has stayed for almost 8 years now.

While I was living on the palliative care unit, where I was supposed to die, I met two other stage 4 prostate cancer patients. Like me they had nothing to lose so both of them did the cayenne pepper cure just like I did. And just like me, instead of just dying there, they were healthy enough to get permanently released. We all agreed, we must spread the truth/word about what happened to us.

Read his other posts in the comments.
This is what really amazed me. He developed a treatment protocol for himself and cured himself and his two friends.

He (777Thomas) ordered capsules from Amazon with the following request: cayenne pepper capsules
He chose capsules with maximum capsaicin (the active ingredient in cayenne pepper) among different manufacturers and took them according to his protocol.
In addition, if you type in Google: Capsaicin and pancreatic cancer, it turns out that he was absolutely right.
It is clear that in this case the concept: DOSE-EFFECT is not defined, and here it is possible that its protocol must be repeated.
These are the thoughts. I hope you find the right path and help your father-in-law.

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#42

AOH 1996 (very experimental cancer med).

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#43

At this point we are thinking about trying 1 mg of daily Rapamycin to slow the cancer cell growth plus the DAV therapy. If he can live several months longer, we’ll count it as a win. I think it’s not possible to cure it at this point. Thoughts?

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#44

Like previously posted here in this thread, it could slow down the cancer. But I don’t know at what dose.

“mammilian target of rapamycin (mTOR) is a very important serine/threonine protein kinase involved in the regulation of energy metabolism, cell growth, angiogenesis and other cellular biological processes.Rapamycin (sirolimus) is a selective inhibitor of mTOR kinase, which can inhibit the activation and proliferation of T lymphocytes to inhibit the immune response.Currently, mTOR inhibitors are also widely used in tumor treatment. Several studies have been performed to evaluate the efficacy of sirolimus in some solid tumors, and encouraging results are obtained. However, the existing studies on mTOR inhibitors and pancreatic cancer treatment are mostly phase I trials, with little evaluation of the efficacy. Therefore, the phase II clinical trial of rapamycin in the treatment of pancreatic cancer is very necessary.”

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#45

Would 1 mg of Rapamycin a day be enough? 2 mg? A big dose weekly? There’s nothing to lose, but I would like to take the most optimal bet.

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#46

If it were me I’d take it daily but start at 1mg for a few weeks and then see if any effects. If not then try 2g and again then see if any effects. If not then try the other end of the scale with 12-14mg fortnightly or 30mg once every four weeks. Again then see if any effects. Hopefully one of those shows at least a halt in progression which buys you time to try other things.
Keeping my fingers crossed for you - good luck!!

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#47

Does anyone know how much Rapamycin Dr. Blagosklonny is taking? I would like to give the same regimen to my father in law for his cancer. Thank you.

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#48

Thanks for the wonderful responses in other threads.

Dr. Sehgal took 1 mg of Rapamycin daily.

Cancer patients take about 10 mg Everolimus daily which translates to about 5 mg Sirolimus daily.

We may go with 6 mg equivalent or 2 mg + GFJ daily.

We will probably need 1-2 rest days each week. How many should he do?

Thoughts on this proposed protocol?

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#49

Can anyone comment on doing the DAV therapy (Doxycycline Azithromycin Vitamin C) and Rapamycin at the same time. Is it a good idea or not? Thanks for any input.

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#50

I am sorry for your problems. You are certainly a good and kind son-in-law.
I have done the DAV therapy twice. Once I stopped taking rapamycin the second time I was on my regular 1/week schedule. I had zero side effects or any subjective effects which I assume is because I don’t have any known cancer.

If I were to advise anyone, and I wouldn’t want to, who had a cancer problem that wasn’t being helped by conventional methods, I would take Dr. Blagosklonny’s advocacy and take the highest tolerable dose of rapamycin. His opinion papers indicate that he believes it is a cancer treatment.

As for the DAV treatment, I would follow the regimen advocated by Joseph.

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#51

It seems that Sirolimus (Rapamycin) can be effective at weakening cancer on its own. However, when a traditional chemotherapy is added, the effects are even greater. I wish we hadused Rapamycin in addition to chemo in the first place!

After consulting with the hospital, we are considering the last chemotherapy that they have available, TS-1 combined with Sirolimus. TS-1 converts to 5-Fluorouracil in the body. Unfortunately, the cancer may already be resistant to it as it was used in another treatment already. Still, we hope that the addition of Sirolimus will make the drug effective again. If so, then this could open up the door to trying other chemo drugs already used paired with Sirolimus to extend lifespan.

In the early-treatment experiment, the tumor growth rate was inhibited by 48% in the group treated by rapamycin alone, by 34% in the 5-fluorouracil-treated group, and by 60% in the group treated with rapamycin plus 5-fluorouracil compared to the control mice

There are already precedents set for Gemcitabine resistant cancers, such as adding Sirolimus, where the resistant cancers are affected by Gemcitabine more than non-resistant cancers due to the Sirolimus.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947835/

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#52

Perhaps consider

Our clinical trials looking into Fast-Mimicking Diet (FMD) and cancer prevention and treatment are ongoing. But if early results are any indication, it could be a powerful new weapon in the arsenal we have to fight, and one day defeat, cancer.

Papers etc here Cancer - Valter Longo can also check the latest clinical trials

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#53

Update: Father in law took his fast acting insulin and then forgot to eat, so it’s probably not the Rapamycins fault for the hypoglycemia.

#54

Found this other comment by John Hemming citing research that sodium citrate (+ other citrates) can potentiate both chemotherapy and Rapamycin in the treatment of cancer : A concern about senolytics not supported by mouse studies - #7 by John_Hemming

This may be related to the alternate medicine Alkaline Approach mentioned by Viktor above. Sodium citrate (balanced with other citrates, like potassium and magnesium citrates and taken in several doses over the day to avoid electrolyte imbalances) does indeed Alkalinize many tissues including cancer tissues. John Hemming has reported that his Urine has a PH of 9 or 10! The oral dosage in mice that was effective for cancer is 500mg/kg/day, not clear how that scales to humans.

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#55

This is the mass vs square meters of skin question. Obviously for a 80kg human if that scales it would be 40g. I tend to measure the mass of citrate which is perhaps 2/3 of the citrate salt (it varies depending on the cation). There is an additional complication that the different salts have a tendency to have a bit of water with them as well.

There is an interesting question as to whether the alkanisation of the tissues is itself positive separate to the provision of citrate.

Blood transfusions tend to come with a large dose of sodium citrate as well.

As an alternative scaling
https://www.publish.csiro.au/bi/pdf/bi9670687#:~:text=From%20Figure%201%20the%20surface,2-90·4%20cm2%20.

From Figure 1 the surface area of a mouse weighing 25·7 g is estimated to be 78·6 cm2 , with a range (95% confidence limits) of 68·2-90·4 cm2 .

So lets say the mouse is 25g which means a dose of 500mg*0.025= 12.5mg
Using the figure of 1.6square metres for humans and 80square centimetres (80/10000 square meters) the ratio would be 200 which gives a dose of 2.5g.

I think 2.5g is very low.

Alternatively mice eat about 5g a day and humans perhaps 1.2kg which is a ratio of 240.

That fits closer to the skin ratio. The mass ratio is 3,200.

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#56

correction: you mean obviously 12.5mg

#57

You are right about this. I will fix the post.

#58

Another peptide worth looking into regarding cancer is PNC 27. And specially for pancreatic cancer:

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#59

Good call. It’s called safeguard for good reason, not much downside. My daughter has been on high dose for a long time and she just got scanned a couple days ago, no evidence of disease.

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#60

Since we are talking about last-ditch efforts, I might add this paper reviewing different peptides which may fight cancers. I have no firsthand knowledge of these but the paper came up in something else I was reading (PNC-27 out of pure interest as someone who had cancer and is intrigued by peptides and their possibilities). Maybe there are some possibilities for your family they may be synergistic (or not obstructive) to what you are already trying.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359827/

In the paper they mention specifically for pancreatic cancers:

PNC-2 and PNC-7 in vitro Pancreatic cancer (MIA-PaCa) cells [109]

|Cardiac natriuretic peptides|In vitro & in vivo|Pancreatic cancer (HPAC), renal carcinoma (SW156), breast adenocarcinoma (HCCI428), ovarian adenocarcinoma (NIHOVCAR-3), modularly thyroid carcinoma (TT), glioblastoma (LNZTA3WT4) and lung carcinoma (NCI-H1963) cells|

p16 In vitro Pancreatic cancer (AsPC-1 and BxPC-3) cells [166]

PNC-27 In vitro Cervical carcinoma (HeLa), colon cancer (SW1417 and H11299), breast cancer (MDA-MB-453 and MCF-7), osteosarcoma (SAOS2), leukaemia (K562), pancreatic cancer (MIA-PaCa-2) and melanoma (A-2058) cells. Rat k-ras-transformed pancreatic cancer (TUC-3) and transformed endothelial (E49) cells [214, 216, 217]

PNC-21 In vitro Cervical carcinoma (HeLa), colon cancer (SW1417 and H1299), breast cancer (MDA-MB-453), and osteosarcoma (SAOS2) cells. Rat k-ras-transformed pancreatic cancer (TUC-3) and transformed endothelial (E49) cells [214]

PNC-28 In vitro & in vivo Breast cancer (MDA-MB-453), colon cancer (H1299 and SW1417), osteosarcoma (SAOS2), cervical carcinoma (HeLa) and pancreatic cancer (MiaPaCa-2) cells. Rat k-ras-transformed pancreatic cancer (TUC-3) and transformed endothelial (E49) cells [214, 219,

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