正如我们在《技术季刊》中提出的，这个想法是操纵与衰老相关的生物过程，当实验动物受到抑制时，似乎可以延长它们的寿命。其中一些是熟悉的，例如严格限制动物消耗的卡路里数量，作为平衡饮食的一部分。对于大多数人来说，过上如此限制卡路里摄入的生活是一个过高的要求。但影响相关生物途径的药物似乎会带来类似的结果。其中之一是二甲双胍，已被批准用于治疗 2 型糖尿病；另一种是雷帕霉素，一种用于器官移植的免疫抑制剂。早期采用者开始自行“脱离标签”服用这些药物，或者与新型长寿公司签署相当于服务合同的药物。
全文：https: //archive.ph/2SxZp
更多文章和讨论请参见： 延缓衰老变得严重 - #3 by RapAdmin
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Nothing really new in here,
全文：https: //archive.ph/2SxZp
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A full issue on “ageing”
In search of forever
TECHNOLOGY QUARTERLY - SEP 30TH 2023
Slowing, let alone reversing, the process of ageing was once alchemical fantasy. Now it is a subject of serious research and investment, Geoffrey Carr reports
Living to 120 is becoming an imaginable prospect
完整文章在这里：https://archive.ph/JWaHl#selection-895.0-895.49
And breaking the paywall a bit… the same stories fully accessible:
https://archive.ph/OUCoN
https://archive.ph/FTkkB
https://archive.ph/9hURu
https://archive.ph/ACawU
https://archive.ph/7wUWC
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In a serious magazine like the Economist, this is a notable event. The intelligentsia are going to be aware of what is possible, and that will open up new doors. Slowing ageing transitions from the fringe to the elite.
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Its interesting - we get more visitors here (mostly readers/lurkers) from London than I think we get from New York City… which has surprised me. Perhaps they feel they need to live longer so as to survive the negative repercussions of Brexit 
And, below, a video from The Economist, as part of this series. Rapamycin is well represented but Geoff seems to have more enthusiasm for metformin, which I think is a mistake.
So how you do you classify yourself - charlatan, nutter, or serious scientist? I suspect Geoff Carr would put most of us here in the “nutter” category.
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AnUser
#6
On a good day I’m a nutter, on a bad day I’m a serious charlatan. It depends on my mood. 
"Sometimes, greatness borders on insanity vs brilliance. I’m comfortable on that edge! " - Michael Lustgarten.
If someone doesn’t soften their inhibitions every now and then they’re just going to repeat what they’ve seen on MSM or learned in school and never think outside the box.
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I try to keep up to speed on the science relating to healthspan/longevity. When it comes to up to date and considered scientific analysis I don’t think you can beat Rapamycin.news (which is in part the standard of contributors and in part the sensible moderation from RapAdmin). You cannot really expect a mainstream non specialist outlet like The Economist to get the science up to date and have a good look at the controversies.
A lot of the conferences are the usual suspects going around giving their usual presentations.
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I like this paragraph (and the culture is alive and well here)… I think he’s talking about us 
Beneath the forest canopy of firms backed by tech royalty an undergrowth of more conventionally financed startups is working on drugs that might slow or stall some aspects of ageing. Even closer to the ground, the idea is catching on of prolonging lifespan and healthspan using pills and potions that are already available, in addition to (and sometimes instead of) the conventional approach of diet, exercise and early-to-bed. A culture of do-it-yourself lifespan extension is emerging, at least in affluent places endowed with the sort of technical expertise and technological hubris identified with Silicon Valley.
Source: https://archive.ph/2SxZp#selection-1063.0-1063.617
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I think they are referring there to a geographical location. It would perhaps be interesting to know where on the globe the participants in rapamycin.news actually live or work. My impression is that this forum is global rather than geographical. Perhaps we should set up a mechanism for people to indicate their approximate locations. (ie cities, counties).
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Here are some snapshots of where people come from for the site… about 90% of visitors are US-based… and it drops off quickly after that.
Here is what the “activity map” looks like at a few different times of the day, showing where activity is coming from:
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I might be a part of that 'London-lurker" phenomenon 
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We are quite spread out.
A show of hands of the NC tribe members? Asheville vicinity?
Another video from The Economist as part of this series on longevity:
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blsm
#15
My Midwest US location didn’t even make the map!
I just did some screen captures at some various times of the day… I just missed doing it when you were on the site…
And, a new article by the Economist as part of this series below. Nothing really new for people here, but perhaps interesting to see what is being conveyed to a mainstream audience by publications like the Economist.
Full article: https://archive.ph/L26qS
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blsm
#17
Indiana, what a sad and lonely state for longevity.
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