#1

I have been using sermorelin for about 1 1/2 years. I just began my rapamycin induction 2 weeks ago with a 2mg, then 4mg dose. I feel that these two medications would be complementary, but I have not been able to find any information regarding the combination. Would appreciate any info. Thank you

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#2

What/why do you think “sermorelin” is beneficial with or without rapamycin for longevity?

#3

Why do you take sermorelin?

#4

I’m taking the sermorelin for overall wellness, fitness, sleep, energy, and exercise recovery. I do not believe it contributes to longevity, but definitely to fitness, wellness and to healthspan. I believe that these two medications would be complementary.

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#5

I began during recovery from a bad orthopedic injury 3 yrs ago requiring 18 surgeries and bone grafting. It was suggested to facilitate the bone graft, and I am now fused. I continue as I feel good, and have recovered, sleep well and am able to participate in high level athletics again at 58yo.

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#6

I’ve been taking MK677 (Ibutamoren) with rapamycin periodically. The theory being that rapamycin will counteract the pro-aging effects of growth hormone. But there’s little evidence of that, and you need to be careful with glucose control – the agents might synergise the wrong way. Overall I think that the ghrelin analogues are probably safer than the GHRP analogues – ghrelin itself has pro-longevity properties.

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#7

Interesting, I was not familiar with this compound. How is it going for you? What have been your perceived or measured results?

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#8

Hard to say. Unfortunately I can’t afford a CGM or super-regular blood tests, so I’m perhaps irresponsibly under-instrumented. Subjectively I’ve had a slow but marked improvement in my health, but that’s coming after making several changes at once out of desperation. As for acute effects, all I can say for sure is occasional but unpredictable hunger and craving high calorie foods.

MK677 is modestly popular in the bodybuilding/PED circle. You can find a few reports of blood sugar problems on their forums, consistent with the clinical trials where it rose over months at higher doses. I’ve run 15mg 3 times a week, 1 month out of 3, for a year, more or less. This is out of caution – I assume the optimum is either none (it’s a bad idea) or higher.

Of note, a recent report suggests that such compounds do extend the life of mice, so long as they aren’t allowed to increase food consumption.

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#9

I take 1ml of MK677 daily for GH support. I do strength training 3 times a week. It definitely helps with muscle building.

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#10

Hi Rap,
I just saw this old post as I was searching for information regarding taking semorelin with Rapamycin.
I have been on TRT for 5 years and Rapa for 9 months. Since beginning Rapa I have lost strength. I am weaker than before. Rapa definitely slows my strength gains down greatly.
I plan on only use the peptide for 3 months then take a few months off.
I saw a few posts indicating that the two may conflict and actually work against each other.
Asking for a friend. Ty

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#11

What dose and frequency, and what is your body weight?

This is atypical, as generally lean body mass improves with cyclic rapamycin. However, everyone is different.

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#12

Hello Doctor,
I take 2mg rap with 10oun GFJ once a week for the past 2 months. Prior I was just taking 5mg a week. Ty I am 210

#13

Unusual, so equivalent of ~6 mg/week at 210 lbs. Much lower than I’d usually target for. I am 165-170 lbs and take 4 mg w/ GFJ, but my interval is 12-14 days. However, on average 3 mg w/ GFJ would be minimum for every 7 day dosing for most people in you weight, if you were my patient.

But remarkably, you had worse health outcome/muscle with such a low dose. Very odd. Is there something else that would explain this?

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#14

Not to my knowledge. I was strong like bull until starting Rapa now mere mortal.

#15

Did you look at your IGF-1 off of Rapa? I wonder if you were stimulated through the roof = early death and rapa is bringing that down to earth to the mortal, rather than the prematurely dead which happens with too much stimulation.

I’m a mere mortal, and yes, could drive up muscle mass hugely in a number of ways, but there needs to be a careful middle ground if the focus is longevity.

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#16

Totally understand but my IGF 1 stays between 100 and 120. Will report back after a month of using Rapa with Semorelin. Ty

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#17

I use a combo dose of Ipamorelin+CJC1295-noDAC and separately 75mg DHEA 5 nights a week just before bed time. I take 6mg Rapa with GFJ every 2 weeks. Been doing the Rap for over 2 years now and these specific peptides for about 14 months.

Have not noticed any influence on my strength that I’d attribute to this protocol. I had not been working out for a couple years and started back at it 3 months ago. All good here, weights increasing, endurance increasing, Last week I was “showing off” for one of my sons and easily cranked out 25 push-ups. Probably could have done 30 but it was getting hard so I thought I’d quit while I was ahead LoL! 4 years ago I was doing 100 push ups a day in sets of 20 at random times during the day. I was 55lbs over weight at that time though.

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