Are you going to take all of it in one dose or spread it throughout the day?
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I dump the whole dose in my morning coffee along with Glycine and Collagen. I heard Taurine may interfere with sleep so I want to take it as early as possible.
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How big is that coffee? I usually dose glycine powder (9 g) at night mixed in water with flavored magnesium citrate powder and use that to wash down my collagen pills (and the rest of my evening stack). Maybe it is cold liquid vs hot liquid, but I have to stir a lot. It’s worse when I add creatine (5 g) to the mix.
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And while we’re at it, which taurine powder are you using?
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I use just a normal mug of hot coffee. Most of the powders dissolve well although I do add some hot water afterwards to get more of the powder that doesn’t dissolve.
I use this brand for taurine
https://www.amazon.com/BulkSupplements-Taurine-Powder-500-grams/dp/B00ENSLW7U/
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I like what I see on this… I just ordered 2.2 pounds. Thanks for all the research and link … all at one’s fingertips. I am done with Fisetin… used last capsule last night. Not reordering.
Why the members on this site rock. Honest reliable feedback.
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50mg was the dose that Dr. Garcia in Las Vegas (recently retired) put me on.
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Senescent cells are typically associated with aging and health problems, but a new study adds to the growing evidence that “zombie” cells can actually be beneficial.
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I think a lot of senescent cells are stuck in differentiation
Yes, senescent cells are great for wound healing and regeneration. Unfortunately I don’t regenerate and I don’t want the inflammation that these cells cause. I don’t mind slower healing wounds if I can forgo the inflammation.
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Jay
#133
I use dasatinib + quercetin every 3 months, but today I read two interesting articles related to the use of azithromycin as a senolytic. This is new information for me and it may be news to you also. The first article provides the basic information, but also mentions that azithromycin is currently used for cystic fibrosis which is why I included the second article. If you read the second article you’ll notice that azithromycin has also been used for non-cystic fibrosis with success. It’s interesting reading if you have the time.
The efficacy of azithromycin to prevent exacerbation of non-cystic fibrosis bronchiectasis: a meta-analysis of randomized controlled studies - PMC.
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Lowroad
#134
Would you mind sharing how you obtained 17 Alpha estradiol? I have been to take it, but I struggle sourcing it.
Thanks
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I take the topical Pantostin. Not sure how much is absorbed, but hormones usually pass readily through skin.
Here’s one from Amazon.de (Germany)
https://www.amazon.de/-/en/30998-PANTOSTIN-Solution-100-ml/dp/B00DIWYBS4
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Apparently, Dr. Blagosklonny is not a fan of senolytics as they just suppress mTOR to a lesser extent than rapamycin.
“Dasatinib plus Quercetin) extend lifespan in mice. These senolytics slightly inhibit the mTOR pathway. Thus, life extension by these senolytics can be explained by their slight rapamycin-like (gerostatic) effects.”
Mikhail V. Blagosklonny, MD, PhD
@Blagosklonny
I discussed in 2021 that, by strict definition , senolytics do not exist. Nothing changed. Senolytics are less fashionable
pubmed.ncbi.nlm.nih.govAnti-aging: senolytics or gerostatics (unconventional view) - PubMed
Senolytics are basically anti-cancer drugs, repurposed to kill senescent cells selectively. It is even more difficult to selectively kill senescent cells than to kill cancer cells. Based on lessons…
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Lowroad
#137
I will order the same! Many thanks!
I disagree with you Dr. B. Senolytics do work, it’s just they’re probably 25% as effective as senomorphics. Now if you combine senomorphics like Rapamycin and Taurine, then you apply Senolytics to remove any that do form, that’s a powerful combination.
If you eliminate senescent cells, you eliminate a majority of disease. For example, the Japanese study where they took arteriosclerosis prone mice and gave one group a Senolytic vaccine. None of the mice developed clogged arteries. While the control group all of them did! Why? The vaccine treated mice did not have any senescent cells in their arteries causing inflammation. Without the inflammation, the cholesterol couldn’t stick and block the arteries.
No senescent cells = Less inflammation= No heart disease!
By this fact, regular Rapamycin users should not have much heart disease. Can we corroborate this?
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I didn’t say anything pro or con. I just cited Dr. Blogosklonny.
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No worries. I edited the above post
And even if we disagree on something, it’s just an open door for a friendly debate. 
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KarlT
#141
Has anyone used Azithromycin as a senolytic and if so, how did you determine dose?
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scta123
#142
Not really, but was looking at it a while ago. The study was done in vitro and in vivo the senolityc concentration is almost unattainable in humas since it could be potentially fatal (8-10g or somethig like this).
There are two interesting things I found that might be worth something. Did not really go into depth but maybe someone here would be interested in studying more.
In the examples of anti-aging embodiments, treatment with this approach was directed over a repeating cycle. The compositions include azithromycin as a first antibiotic that inhibits large mitochondrial ribosomes, doxycycline as a second antibiotic that inhibits small mitochondrial ribosomes, and vitamin C as an oxidation promoter to induce mitochondrial oxidative stress. Including. For 5 weeks, azithromycin was administered at 250 mg twice weekly, doxycycline at 100 mg twice daily, and vitamin C at 500 mg once daily. A 77-year-old man of interest had hair growth, mental cognition and agility, strength and stamina, and increased libido, as well as visual acuity, hearing, conversation, coordination and balance, overall well-being and vitality. Reported improvement. The recipient also reported the disappearance of clinically palpable prostate nodules after treatment with this approach, with no other medications, diet, exercise, and changes in daily life.
This is google translated from a japanese patent application for drug combination. Link to application.
And this study:
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