#103

Per Dr. Alan Green’s prescription.

#104

Senolytics: Which ones work?

Can anyone post the text?

1 Like
#105

Where do you get Dasatinib?

#106

Ok, as ‘luck’ would have it I came across this article AFTER my first dose of 100mg Dasatinib in combination with 2000mg Fisetin last night. To be honest, I was terrified as I read all the drug interactions and possible side effects. The slightest discomfort and I assumed a cardiac event. But I knew I would be that psychosomatic so I took it before I knew I would fall asleep (with loads of melatonin to be sure).

Got a slight headache today, but feeling fine. My fears are gone - a bit like going down a slide for the first time as a kid.

I am also taking 6mg Rapamycin (with 100mg doxycycline) once weekly, 17 Alpha estradiol, Arcaboze, metformin and Canagliflozin. I am in my 40s.

I do not intend this to be advise for anyone. However, having come across this posting I will research potentially downsides further.

I suppose the message of this post is twofold: 1) everyone’s risk-reward curve is different and 2) Dasatinib (although a powerful drug) wasn’t as scary (for me at least) as the patient leaflet had me believing :joy:

4 Likes
#107

DeStrider, any luck getting the full text of the New Scientist article?

#108

Just click on this link:

5 Likes
#109

:joy: :joy: :joy:

Despite these warnings, there is a community of biohackers who take these drugs on a regular basis. They are “very cheap, readily available and easily used”, says one user who asked to remain anonymous.

Don’t follow their example. These compounds can be toxic, warns Linda Partridge at the Max Planck Institute for Biology of Ageing in Cologne, Germany. “Make sure your readers don’t take these agents,” Kirkland tells me. “The only place for them at the moment is in clinical trials that are carefully controlled.”

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#110

Translation: They may work, or they may shorten your life.

Senolytics are like the crypto of biohacking.

Rapa is like a Tbill.

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#111

Update: Just had my 1 year follow-up with Dr. Green, He’d recommended I take my 50 mg Dasatnib 3 days in a row every other month (as opposed to 1 - 50 mg dose per month), and continue my weekly dose of 4 mg of Rapamycin.

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#112

If i am right that many senescent cells are those which have failed to differentiate from stem cells because of a failure of gene expression, then improving gene expression will make them function. My experiments point to this being true. One route to this is through HDAC inhibition through molecules like fisetin, curcumin and pterostilbene. It also takes CRP down as a biomarker.

2 Likes
#113

Terri, That is an interesting method. I wonder why Dr. Green chose that method? I’ve been doing a senolytic therapy method of 100 mg Dasatinib + 1 gram of Quercetin three days in a row every three months. It looks like I may have to research this topic again.

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#114

does follow-up have to be in person?

#115

Senolytics, which remove old zombie cells, prove safe and beneficial in non-human primates. Another step closer🚀
Key Paper: http://tinyurl.com/34zuv4vw

5 Likes
#116

No, we spoke over the telephone. He puts a lot of stock in one’s HOMA-IR, so I made sure to have bloodwork prior to our call.

#117

SUMMARY: It’s better and more effective to prevent senescent cells using taurine or rapamycin than to remove them later using senolytics. But, you could probably do both (taurine + senolytics) and the benefits would probably stack. Probably Rapa and Taurine as well.

If senolytics are good, then taurine is even better.

I liked the study from the video below where they tested mice for senescent cells. They had three groups - control, senolytic, and taurine dosed. The control group had a normal senescent cell load (no surprise). The senolytic-treated group had fewer senescent cells and a longer lifespan (~10% longer). The surprise was the taurine-dosed mice had fewer senescent cells than either of the other two groups along with a much longer lifespan than the others (~37% longer!!!).

Reference Video (time 5:50):

11 Likes
Should we take Rapa the same week as senolytics?
Emulating the benefits of IL-11
Has anyone used dasatinib+quercetin (D&Q) as a senolytic?
#118

You’ve sent me down the rabbit hole. Very quick, dirty googling tells me taurine supplementation is pretty good for people before considering the impact on senescent cells.
Taurine and the renal system - PMC.
The beneficial effects of taurine in alleviating fatty liver disease - ScienceDirect.
Taurine and inflammatory diseases - PubMed.

What I heard in your video link is doses of 3 to 6 mg daily.

Now to find out the drawbacks.

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#119

In addition, the Columbia U study was suggesting 3 to 6 g of Taurine daily. That also showed improved life expectancy from Taurine supplements. Taurine is inexpensive and effective.

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#120

I’m down to my last “hit and run” dose of fisetin. Taurine in the future.

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#121

https://www.science.org/doi/abs/10.1126/science.abn9257

The authors concluded: “Taurine abundance decreases during aging. A reversal of this decline through taurine supplementation increases health span and life span in mice and worms and health span in monkeys.”

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#122

Since mice, monkeys and humans all show a decreased level of taurine in old age (20% of youthful levels) AND supplementation of taurine in mice and monkeys extends lifespan and healthspan AND supplementation of taurine in old humans has shown positive effects on healthspan, I think it’s safe to make the jump to assume taurine will extend the lifespan of humans significantly. Plus it may prevent cells from becoming senescent.

Taurine is inexpensive and doesn’t have any significant side effects. It’s a no-brainer addition to my supplement stack.

5 Likes