#1

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Hi, all…

In a recent post, I was asking whether Rapamycin might

either

open the door to Myeloma/Bone Marrow Cancers,

…or, Protect Against It…

…Because I don’t have the scientific knowlege to understand…

…But nobody answered,

so I was obsessively Googling,

and looked up, instead,

"Free Kappa Light Chains

(of which, mine were elevated :frowning: )

/ NF Kappa B,

and Rapamycin" -

…And stumbled upon this Pubmed article

( Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence - PMC )

which posits that

…Kappa Light Chains,

under SOME circumstances,

might be a Good thing?

…AS WELL AS,

that Cellular Senescence

(in SOME circumstances)

might be a Good thing -

??? …IS that, in fact, what this article is saying??? -

And then, if so,

…are the Senescent Cell “Clean Up” formulas I’ve been taking,

possibly harmful to me, In Terms Of Cancer Prevention?

(The article also does mention MTOR, and, Histone Deacetylase -

but again, I don’t have the scientific knowlege to understand it As Worded…)

…I’ve always thought Senescent Cells need to be cleaned out,

but now am confused.

And feel, in general, like I’m walking through a mine field :frowning: -

Questioning “Why are my Free Kappa Light Chains elevated?,”

and "Could there be any other reason than …Cancer? :frowning: " -

…Which led me to that article…

…So if anyone could please take the time to help me understand,

…Please help me

Thank You So Much…

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#2

NF-κB (also Nuclear Factor kappa B) is a transcription factor which is part of the cell’s major response to threats. In fact it increases the level of citrate by stimulating production of SLC25A1.

This helps in the production of cytosolic ROS. However, when NF-κB is inhibited by IL-10 via the Janus Kinase this can prevent the production of sufficient acetyl-CoA to get a cell through to differentiate. Hence you get senescence.

The arguments about Rapamycin are that
a) It inhibits the production of all white blood cells. These cells are used to attack cancer cells.
b) It makes cancer otherwise less likely by improving mitochondria.

That is a really useless answer about cancer, but no-one at this stage has enough information to tell you whether a) or b) dominates.

2 Likes
#3

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Thank you for taking the time to answer, I really appreciate it…

Do you

(or does anyone reading this)

have any insight on

…reasons why Kappa Free Light Chains would be elevated -

and any Other reason than Cancer, why Kappa Free Light Chains would be elevated?

Thanks so much!

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#4

If you refer to NF-κB (also Nuclear Factor kappa B) rather than Kappa Free Light Chains you might find more of an answer.

“nuclear factor kappa-light-chain-enhancer of activated B cells” = NF-κB

The little κ is actually a greek letter κ

People use the roman name of “kappa” because at times it is hard to type a: κ

Whilst I am at it I will mention that I think there are three key messaging systems in cells responding to threats, HIF 1 alpha, NRF2 and NF-κB. I consider them the builders, the fireman and the army. (in that order).

It is not entirely valid as when a stem cell is differentiating NF-κB is jacked right up.