约瑟夫
#261
FWIW
A paper on testing, older from October, 1990
“Taurine concentrations in plasma and whole blood in humans: estimation of error from intra- and interindividual variation and sampling technique”
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Are you sure that was serum and not whole blood?
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约瑟夫
#263
The more you dig …
Published online 2012 Feb 10
“Serum taurine and risk of coronary heart disease: a prospective, nested case-control study”
Pharmacokinetics of Oral Taurine in Healthy Volunteers
The Dose Response of Taurine on Aerobic and Strength Exercises: A Systematic Review
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Ulf
#264
RapamycinCurious:
A most relevant question since the result is hard to believe. I will ask for confirmation from the tester.
However, I have assumed it was serum, since the reference range given fits with the serum levels shown in that graph for different ages for humans.
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karismac
#265
Just a quick update - I am still taking 4 gms of Taurine overnight but after reading here might start to double that. After the positive effects it has had on my autism my son who is on the spectrum has begun taking it too. Many changes in my life from this. I am multitasking and scheduling much better. My focus is more rational and people respond to me more positively. As for longevity I can’t say conclusively but am certain that I am looking and feeling younger. That could be the culmination of many things I have been doing for close on a year now but the results have really become noticeable since I started the Taurine. I agree with my son who says, yes this is good, but also scary because I feel like the hiding place in my mind is gone.
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Ulf
#266
I got the answer from the testing company:
“Amino acids are measured in serum and the reference ranges are based on a healthy population as are those for most reference ranges”.
So it appears I am an outlier, with my value of 141 micromol/L before supplementation being that of a teenager although I am 76 (page 3 on the chart in the Taurine as driver of againg article)… Could it be that my extteme health habits, such as CRON caloric restriction with optimal nutrition, 4-hour food window etc, plays a part?
On the other hand, when I trsted my AKG the number corresponded to my chronological age.
The biggest outlier in the chart is a 55-year person with 210. And there is a 25-year old with 290. I may aim for the 250 - 300 range. Will continue with at least 1.5 g of taurine.
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medaura
#267
Everyone, I had been on a 4 week pharma vacation while on real life vacation and have just started getting back into my supplement routine. Yesterday I mixed in my tea, 500 mg Niacin, collagen peptides (mix of amino acids), colostrum, lion’s mane powder, and 10 GRAMS of Taurine, based on my reading here that we’re probably undershooting the dosage by orders of magnitude. But I felt pretty crappy starting about 30 min later — completely wiped out, in fact I had to lie down on the spot.
My oura markers are absolute 
— very high resting HR, low HRV, higher body temp, etc. though somewhat surprisingly the sleep had a very high % of deep and rem sleep even though I woke up way too early.
I seem to recall some people had problems with high doses of Taurine or did I dream that? I’ll repeat the experiment in a few days to see if that’s what caused it. There’s a chance it might be a transient cold as two of my kids are recovering from one but I doubt it.
Wondering if this is a supplement where your mileage might vary. The two previous days I’d tried the same cocktail but without niacin and only 2-4 g Taurine. The niacin flush had never bothered me before or yielded bad Oura measurements.
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I was drinking a lot whilst on holiday, but a day off the booze and then a day fasting took my RHR to 50 and HRV to 59ms (I am 63). Sadly I have had a couple of drinking days then and it is a bit hot in the UK at the moment. However, I expect to get on track soon.
I did a blood test yesterday so I now have a holiday baseline and intend having a real go at HDAC inhibition (I have 20 molecules to test now), acetyl-Coa (I have already increased citrate supplementation) and ATP boosting (I am running through testing individual molecules preparing to test combinations).
I have some really nice coloured boxes for the HDAC testing, but some of the molecules require making soup from roots (not necessarily a bad idea) as the supplements don’t exist as yet.
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LaraPo
#269
Do you usually have RHR in the 70s? It corresponds to mine when I walk. Could it be niacin?
medaura
#270
My HRV is mostly seasonal. Summer and this time of year it can be in the 70s-90s and it’s for me the best indicator of how I feel: the higher the better, largely overruling all other indicators like sleep or temperature or even resting heart rate. You can imagine how I feel today given my stats.
But my question is, did Taurine cause this? It was the first time yesterday that I tried such a high dose of taurine (10 g). In the past I’d done 2, 4 g tops. Niacin was my regular dosage. I seem to vaguely recall some people said they didn’t feel good after high dose taurine supplementation but I feel too tired and crummy to scour the whole thread for that possible reference.
2 Likes
medaura
#271
Oh I realized you asked about RHR not HRV — I feel so crummy I’m brain tootin’. No my RHR is typically in the low 60s or mid 50s. Last night I could feel my heart pounding in my chest at night.
Its an indicator of the balance between sympathetic and parasympathetic nervous system. Higher is more towards parasympathetic. Hence breathing exercises/meditation can drive it higher.
What I am looking for is good tools to identify when ultradian cycles start and to measure the balance between sympathetic and parasympathetic systems. It would be nice to control these things consciously.
@John_Hemming body clocks aside, can’t you impact your sympathetic vs parasympathetic state (measured via HRV) with breathing exercises (fast breathing with breath holds) vs deep slow breathing with extended exhales)? Music (high vs low tempo)? I can remember squeezing the pressure point between my thumb and index finger to stay awake in early morning college classes (pure agony).
Yes there are a number of techniques to affect the balance between sympathetic and parasympathetic including stimulating the vagus nerve (interestingly different on the right side of body compared to left). However, the question is knowing where the balance is at any one time.
I get a read out from elite HRV using the Polar H10. I don’t, however, know how reliable this is.
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I’ve heard “HRV experts” talk about challenges in getting clear HRV signals from trained athletes. The recommendation is often to take the reading standing vs laying down to boost the signal. Also, they tend to suggest that there are too many influences on the system to get meaningful HRV data except just after waking up before food or caffeine.
Check out HRV4Training
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My HRV is chronically low, although it’s improving I contracted COVID over the Christmas holidays and had it pretty bad despite being fit and active. It actually correlates with my genome, which predicted a high chance of severe Covid.
I’ve managed to raise it by about 25 percent since then and have definitely noticed an improvement in my general mood. I’ve been using a Pulsetto, which also seems to help.
I’m curious. Could it be that people who have high HRVs have potentially experienced less stress throughout their lives or are they more resilient?
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It’s a good question. I’ve understood high HRV to be a sign of health. Of course to be fit, a person has to endure stress which will temporarily knock down HRV. OTOH, I’ve also read it’s best to use HRV as a personal marker of status vs comparing to other people. I rely more on RHR to be honest.
I take the reading lying down having just woken.
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Neo
#279
Interesting. How does one do this?
